Macrophage activation syndrome complicating early course of adult-onset Still’s disease
Introduction. Adult-onset Still’s disease is a rare inflammatory disorder of unknown etiology. It can be complicated by macrophage activation syndrome, a potentially life-threatening condition. While macrophage activation syndrome and adult-onset Still’s disease share similar features, early recogni...
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Serbian Medical Society
2021-01-01
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Online Access: | http://www.doiserbia.nb.rs/img/doi/0370-8179/2021/0370-81792000083B.pdf |
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doaj-ba72d39193774b89b60a6a35faded8902021-03-19T14:14:55ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792406-08952021-01-011491-2747710.2298/SARH190806083B0370-81792000083BMacrophage activation syndrome complicating early course of adult-onset Still’s diseaseBožić Ksenija0Elez Marija1Glišić Branislava2University of Defense, Faculty of Medicine, Military Medical Academy, Clinic of Rheumatology, Belgrade, SerbiaUniversity of Defense, Faculty of Medicine, Military Medical Academy, Clinic of Hematology, Belgrade, SerbiaUniversity of Defense, Faculty of Medicine, Military Medical Academy, Clinic of Rheumatology, Belgrade, SerbiaIntroduction. Adult-onset Still’s disease is a rare inflammatory disorder of unknown etiology. It can be complicated by macrophage activation syndrome, a potentially life-threatening condition. While macrophage activation syndrome and adult-onset Still’s disease share similar features, early recognition is very difficult in clinical praxis. Case outline. We report a young woman, whose illness was presented suddenly, with spiking fever, sore throat, myalgia, arthralgia, and maculopapular rash. In suspicion of sepsis, she received antibiotics, despite no evidence of infection. After two weeks, her condition worsened, which was followed by cytopenia, elevated liver enzymes, and high serum levels of ferritin. She was diagnosed with macrophage activation syndrome in the early course of adult-onset Still’s disease. She was treated with high doses of corticosteroids and cyclosporine A and recovered completely. Conclusion. Macrophage activation syndrome can occur at the beginning of adult-onset Still’s disease. Early recognition and timely administration of immunosuppressive drugs are important for the successful outcome in this condition.http://www.doiserbia.nb.rs/img/doi/0370-8179/2021/0370-81792000083B.pdfmacrophage activation syndromeadult-onset still’s diseasehyperferritinemia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Božić Ksenija Elez Marija Glišić Branislava |
spellingShingle |
Božić Ksenija Elez Marija Glišić Branislava Macrophage activation syndrome complicating early course of adult-onset Still’s disease Srpski Arhiv za Celokupno Lekarstvo macrophage activation syndrome adult-onset still’s disease hyperferritinemia |
author_facet |
Božić Ksenija Elez Marija Glišić Branislava |
author_sort |
Božić Ksenija |
title |
Macrophage activation syndrome complicating early course of adult-onset Still’s disease |
title_short |
Macrophage activation syndrome complicating early course of adult-onset Still’s disease |
title_full |
Macrophage activation syndrome complicating early course of adult-onset Still’s disease |
title_fullStr |
Macrophage activation syndrome complicating early course of adult-onset Still’s disease |
title_full_unstemmed |
Macrophage activation syndrome complicating early course of adult-onset Still’s disease |
title_sort |
macrophage activation syndrome complicating early course of adult-onset still’s disease |
publisher |
Serbian Medical Society |
series |
Srpski Arhiv za Celokupno Lekarstvo |
issn |
0370-8179 2406-0895 |
publishDate |
2021-01-01 |
description |
Introduction. Adult-onset Still’s disease is a rare inflammatory disorder of unknown etiology. It can be complicated by macrophage activation syndrome, a potentially life-threatening condition. While macrophage activation syndrome and adult-onset Still’s disease share similar features, early recognition is very difficult in clinical praxis. Case outline. We report a young woman, whose illness was presented suddenly, with spiking fever, sore throat, myalgia, arthralgia, and maculopapular rash. In suspicion of sepsis, she received antibiotics, despite no evidence of infection. After two weeks, her condition worsened, which was followed by cytopenia, elevated liver enzymes, and high serum levels of ferritin. She was diagnosed with macrophage activation syndrome in the early course of adult-onset Still’s disease. She was treated with high doses of corticosteroids and cyclosporine A and recovered completely. Conclusion. Macrophage activation syndrome can occur at the beginning of adult-onset Still’s disease. Early recognition and timely administration of immunosuppressive drugs are important for the successful outcome in this condition. |
topic |
macrophage activation syndrome adult-onset still’s disease hyperferritinemia |
url |
http://www.doiserbia.nb.rs/img/doi/0370-8179/2021/0370-81792000083B.pdf |
work_keys_str_mv |
AT bozicksenija macrophageactivationsyndromecomplicatingearlycourseofadultonsetstillsdisease AT elezmarija macrophageactivationsyndromecomplicatingearlycourseofadultonsetstillsdisease AT glisicbranislava macrophageactivationsyndromecomplicatingearlycourseofadultonsetstillsdisease |
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