The ameliorative effect of gallic acid on pancreas lesions induced by 2.45 GHz electromagnetic radiation (Wi-Fi) in young rats
The aim of this study was to investigate the effects of electromagnetic radiation (EMR) on the pancreas tissue of young rats and the ameliorative effect of Gallic acid (GA). Six-week-old, 48 male rats were equally divided into four groups: Sham group, EMR group (2.45 GHz), EMR (2.45 GHz)+GA group (3...
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doaj-ba7993fe0ac24b97853d94b0eb3b3f2c2020-11-24T21:21:47ZengTaylor & Francis GroupJournal of Radiation Research and Applied Sciences1687-85072017-07-0110323324010.1016/j.jrras.2017.04.009The ameliorative effect of gallic acid on pancreas lesions induced by 2.45 GHz electromagnetic radiation (Wi-Fi) in young ratsSenay Topsakal0Ozlem Ozmen1Ekrem Cicek2Selcuk Comlekci3Pamukale University, Faculty of Medicine, Department of Endocrinology and Metabolism, Denizli, TurkeyMehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Pathology, Burdur, TurkeyZirve University, EBN Faculty of Medicine, Department of Pharmacology, Gaziantep, TurkeySuleyman Demirel University, Engineering Faculty, Department of Bioengineering, Isparta, TurkeyThe aim of this study was to investigate the effects of electromagnetic radiation (EMR) on the pancreas tissue of young rats and the ameliorative effect of Gallic acid (GA). Six-week-old, 48 male rats were equally divided into four groups: Sham group, EMR group (2.45 GHz), EMR (2.45 GHz)+GA group (30 mg/kg/daily) orally and GA group (30 mg/kg/daily). After 30 days, serum and pancreatic tissue samples were harvested for biochemical, histopathological and immunohistochemical analysis. Serum amylase, lipase, glucose, and tissue malondialdehyde, total oxidant status and oxidative stress index were increased, whereas total antioxidant status decreased in the EMR group. The histopathological examination of the pancreases indicated slight degenerative changes in some pancreatic endocrine and exocrine cells and slight inflammatory cell infiltrations in the EMR group. At the immunohistochemical examination, marked increase was observed in calcitonin gene related protein and Prostaglandin E2 expressions in pancreatic cells in this group. There were no changes in interleukin-6 expirations. GA ameliorated biochemical and pathological findings in the EMR+GA group. These findings clearly demonstrate that EMR can cause degenerative changes in both endocrine and exocrine pancreas cells in rats during the developmental period and GA has an ameliorative effect.http://www.sciencedirect.com/science/article/pii/S1687850717300468Electromagnetic radiation (EMR)Wi-FiGallic acidPancreasPathology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Senay Topsakal Ozlem Ozmen Ekrem Cicek Selcuk Comlekci |
spellingShingle |
Senay Topsakal Ozlem Ozmen Ekrem Cicek Selcuk Comlekci The ameliorative effect of gallic acid on pancreas lesions induced by 2.45 GHz electromagnetic radiation (Wi-Fi) in young rats Journal of Radiation Research and Applied Sciences Electromagnetic radiation (EMR) Wi-Fi Gallic acid Pancreas Pathology |
author_facet |
Senay Topsakal Ozlem Ozmen Ekrem Cicek Selcuk Comlekci |
author_sort |
Senay Topsakal |
title |
The ameliorative effect of gallic acid on pancreas lesions induced by 2.45 GHz electromagnetic radiation (Wi-Fi) in young rats |
title_short |
The ameliorative effect of gallic acid on pancreas lesions induced by 2.45 GHz electromagnetic radiation (Wi-Fi) in young rats |
title_full |
The ameliorative effect of gallic acid on pancreas lesions induced by 2.45 GHz electromagnetic radiation (Wi-Fi) in young rats |
title_fullStr |
The ameliorative effect of gallic acid on pancreas lesions induced by 2.45 GHz electromagnetic radiation (Wi-Fi) in young rats |
title_full_unstemmed |
The ameliorative effect of gallic acid on pancreas lesions induced by 2.45 GHz electromagnetic radiation (Wi-Fi) in young rats |
title_sort |
ameliorative effect of gallic acid on pancreas lesions induced by 2.45 ghz electromagnetic radiation (wi-fi) in young rats |
publisher |
Taylor & Francis Group |
series |
Journal of Radiation Research and Applied Sciences |
issn |
1687-8507 |
publishDate |
2017-07-01 |
description |
The aim of this study was to investigate the effects of electromagnetic radiation (EMR) on the pancreas tissue of young rats and the ameliorative effect of Gallic acid (GA). Six-week-old, 48 male rats were equally divided into four groups: Sham group, EMR group (2.45 GHz), EMR (2.45 GHz)+GA group (30 mg/kg/daily) orally and GA group (30 mg/kg/daily). After 30 days, serum and pancreatic tissue samples were harvested for biochemical, histopathological and immunohistochemical analysis. Serum amylase, lipase, glucose, and tissue malondialdehyde, total oxidant status and oxidative stress index were increased, whereas total antioxidant status decreased in the EMR group. The histopathological examination of the pancreases indicated slight degenerative changes in some pancreatic endocrine and exocrine cells and slight inflammatory cell infiltrations in the EMR group. At the immunohistochemical examination, marked increase was observed in calcitonin gene related protein and Prostaglandin E2 expressions in pancreatic cells in this group. There were no changes in interleukin-6 expirations. GA ameliorated biochemical and pathological findings in the EMR+GA group. These findings clearly demonstrate that EMR can cause degenerative changes in both endocrine and exocrine pancreas cells in rats during the developmental period and GA has an ameliorative effect. |
topic |
Electromagnetic radiation (EMR) Wi-Fi Gallic acid Pancreas Pathology |
url |
http://www.sciencedirect.com/science/article/pii/S1687850717300468 |
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