The RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs
Back pain: overactive protein causes disc breakdown Treatments targeting a protein that is overexpressed in damaged spinal cartilage could ease degenerative conditions associated with lower back pain. The intervertebral discs are complex cartilage tissues that absorb forces while allowing the motion...
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2020-05-01
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doaj-ba81bf477ca640b2b4595b4f2166f9da2021-05-30T11:47:15ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132020-05-0152586587510.1038/s12276-020-0441-xThe RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discsBao Huang0Yongqing He1Shengwen Li2Xiaoan Wei3Junhui Liu4Zhi Shan5Yue Huang6Jian Chen7Fengdong Zhao8Department of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, Haining People’s HospitalDepartment of Orthopedic Surgery, Haining People’s HospitalDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineBack pain: overactive protein causes disc breakdown Treatments targeting a protein that is overexpressed in damaged spinal cartilage could ease degenerative conditions associated with lower back pain. The intervertebral discs are complex cartilage tissues that absorb forces while allowing the motion of our spines. An immune-promoting enzyme called calcineurin is important in maintaining the supple, gel-like structure of the central part of each disc, the nucleus pulposus (NP). Fendong Zhao and Jian Chen at Zhejiang University School of Medicine Hangzhou, China and co-workers showed that RCAN1.4, a protein known to suppress calcineurin, is overexpressed in damaged human NPs. The team further revealed how a signaling pathway starting with RCAN1.4 suppresses key genes involved in forming the collagen fibers that hold the NP together. They therefore suggest that therapies targeting this protein could benefit patients suffering from disc degeneration diseases.https://doi.org/10.1038/s12276-020-0441-x |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bao Huang Yongqing He Shengwen Li Xiaoan Wei Junhui Liu Zhi Shan Yue Huang Jian Chen Fengdong Zhao |
spellingShingle |
Bao Huang Yongqing He Shengwen Li Xiaoan Wei Junhui Liu Zhi Shan Yue Huang Jian Chen Fengdong Zhao The RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs Experimental and Molecular Medicine |
author_facet |
Bao Huang Yongqing He Shengwen Li Xiaoan Wei Junhui Liu Zhi Shan Yue Huang Jian Chen Fengdong Zhao |
author_sort |
Bao Huang |
title |
The RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs |
title_short |
The RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs |
title_full |
The RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs |
title_fullStr |
The RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs |
title_full_unstemmed |
The RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs |
title_sort |
rcan1.4-calcineurin/nfat signaling pathway is essential for hypoxic adaption of intervertebral discs |
publisher |
Nature Publishing Group |
series |
Experimental and Molecular Medicine |
issn |
1226-3613 2092-6413 |
publishDate |
2020-05-01 |
description |
Back pain: overactive protein causes disc breakdown Treatments targeting a protein that is overexpressed in damaged spinal cartilage could ease degenerative conditions associated with lower back pain. The intervertebral discs are complex cartilage tissues that absorb forces while allowing the motion of our spines. An immune-promoting enzyme called calcineurin is important in maintaining the supple, gel-like structure of the central part of each disc, the nucleus pulposus (NP). Fendong Zhao and Jian Chen at Zhejiang University School of Medicine Hangzhou, China and co-workers showed that RCAN1.4, a protein known to suppress calcineurin, is overexpressed in damaged human NPs. The team further revealed how a signaling pathway starting with RCAN1.4 suppresses key genes involved in forming the collagen fibers that hold the NP together. They therefore suggest that therapies targeting this protein could benefit patients suffering from disc degeneration diseases. |
url |
https://doi.org/10.1038/s12276-020-0441-x |
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