A high methionine and low folate diet alters glucose homeostasis and gut microbiome

A high methionine and low folate diet alters glucose homeostasis and gut microbiome

Hyperhomocysteinemia (HHcy) is considered as a risk factor for several complications, including cardiovascular and neurological disorders. A high methionine low folate (HMLF) diet chronically causes HHcy by accumulating homocysteine in the systemic circulation. Elevated Hcy level is also associated...

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Main Authors: Chak Kwong Cheng, Chenguang Wang, Wenbin Shang, Chi Wai Lau, Jiang-Yun Luo, Li Wang, Yu Huang
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
HMLF diet
Hyperhomocysteinemia
Glucose homeostasis
Gut microbiome
16S rRNA sequencing
Porphyromonadaceae
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580821000157
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spelling doaj-ba980e986e7a40178379fb3a760319022021-02-11T04:22:40ZengElsevierBiochemistry and Biophysics Reports2405-58082021-03-0125100921A high methionine and low folate diet alters glucose homeostasis and gut microbiomeChak Kwong Cheng0Chenguang Wang1Wenbin Shang2Chi Wai Lau3Jiang-Yun Luo4Li Wang5Yu Huang6School of Biomedical Sciences and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong SAR, China; Heart and Vascular Institute and Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, ChinaSchool of Biomedical Sciences and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong SAR, China; Heart and Vascular Institute and Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China; Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaSchool of Biomedical Sciences and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong SAR, China; Heart and Vascular Institute and Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, ChinaSchool of Biomedical Sciences and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong SAR, China; Heart and Vascular Institute and Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, ChinaSchool of Biomedical Sciences and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong SAR, China; Heart and Vascular Institute and Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, ChinaSchool of Biomedical Sciences and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong SAR, China; Heart and Vascular Institute and Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, ChinaSchool of Biomedical Sciences and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong SAR, China; Heart and Vascular Institute and Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China; Corresponding author. 223A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, The Chinese University of Hong Kong, China.Hyperhomocysteinemia (HHcy) is considered as a risk factor for several complications, including cardiovascular and neurological disorders. A high methionine low folate (HMLF) diet chronically causes HHcy by accumulating homocysteine in the systemic circulation. Elevated Hcy level is also associated with the incidence of diabetes mellitus. However, very few studies focus on the impact of HMLF diet on glucose homeostasis, and that on gut microbiome profile. HHcy was induced by feeding C57BL/6 mice a HMLF diet for 8 weeks. The HMLF diet feeding resulted in a progressive body weight loss, and development of slight glucose intolerance and insulin resistance in HHcy mice. Notably, the HMLF diet alters the gut microbiome profile and increases the relative abundance of porphyromonadaceae family of bacteria in HHcy mice. These findings provide new insights into the roles of dysregulated glucose homeostasis and gut flora in the pathogenesis of HHcy-related complications.http://www.sciencedirect.com/science/article/pii/S2405580821000157HMLF dietHyperhomocysteinemiaGlucose homeostasisGut microbiome16S rRNA sequencingPorphyromonadaceae
collection DOAJ
language English
format Article
sources DOAJ
author Chak Kwong Cheng
Chenguang Wang
Wenbin Shang
Chi Wai Lau
Jiang-Yun Luo
Li Wang
Yu Huang
spellingShingle Chak Kwong Cheng
Chenguang Wang
Wenbin Shang
Chi Wai Lau
Jiang-Yun Luo
Li Wang
Yu Huang
A high methionine and low folate diet alters glucose homeostasis and gut microbiome
Biochemistry and Biophysics Reports
HMLF diet
Hyperhomocysteinemia
Glucose homeostasis
Gut microbiome
16S rRNA sequencing
Porphyromonadaceae
author_facet Chak Kwong Cheng
Chenguang Wang
Wenbin Shang
Chi Wai Lau
Jiang-Yun Luo
Li Wang
Yu Huang
author_sort Chak Kwong Cheng
title A high methionine and low folate diet alters glucose homeostasis and gut microbiome
title_short A high methionine and low folate diet alters glucose homeostasis and gut microbiome
title_full A high methionine and low folate diet alters glucose homeostasis and gut microbiome
title_fullStr A high methionine and low folate diet alters glucose homeostasis and gut microbiome
title_full_unstemmed A high methionine and low folate diet alters glucose homeostasis and gut microbiome
title_sort high methionine and low folate diet alters glucose homeostasis and gut microbiome
publisher Elsevier
series Biochemistry and Biophysics Reports
issn 2405-5808
publishDate 2021-03-01
description Hyperhomocysteinemia (HHcy) is considered as a risk factor for several complications, including cardiovascular and neurological disorders. A high methionine low folate (HMLF) diet chronically causes HHcy by accumulating homocysteine in the systemic circulation. Elevated Hcy level is also associated with the incidence of diabetes mellitus. However, very few studies focus on the impact of HMLF diet on glucose homeostasis, and that on gut microbiome profile. HHcy was induced by feeding C57BL/6 mice a HMLF diet for 8 weeks. The HMLF diet feeding resulted in a progressive body weight loss, and development of slight glucose intolerance and insulin resistance in HHcy mice. Notably, the HMLF diet alters the gut microbiome profile and increases the relative abundance of porphyromonadaceae family of bacteria in HHcy mice. These findings provide new insights into the roles of dysregulated glucose homeostasis and gut flora in the pathogenesis of HHcy-related complications.
topic HMLF diet
Hyperhomocysteinemia
Glucose homeostasis
Gut microbiome
16S rRNA sequencing
Porphyromonadaceae
url http://www.sciencedirect.com/science/article/pii/S2405580821000157
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