Silk Particles as Carriers of Therapeutic Molecules for Cancer Treatment
Although progress is observed in cancer treatment, this disease continues to be the second leading cause of death worldwide. The current understanding of cancer indicates that treating cancer should not be limited to killing cancer cells alone, but that the target is the complex tumor microenvironme...
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doaj-ba9eb40ed51e4911838216c2118404be2020-11-25T04:09:08ZengMDPI AGMaterials1996-19442020-11-01134946494610.3390/ma13214946Silk Particles as Carriers of Therapeutic Molecules for Cancer TreatmentAnna Florczak0Inga Grzechowiak1Tomasz Deptuch2Kamil Kucharczyk3Alicja Kaminska4Hanna Dams-Kozlowska5Chair of Medical Biotechnology, Poznan University of Medical Sciences, 61-866 Poznan, PolandChair of Medical Biotechnology, Poznan University of Medical Sciences, 61-866 Poznan, PolandChair of Medical Biotechnology, Poznan University of Medical Sciences, 61-866 Poznan, PolandChair of Medical Biotechnology, Poznan University of Medical Sciences, 61-866 Poznan, PolandChair of Medical Biotechnology, Poznan University of Medical Sciences, 61-866 Poznan, PolandChair of Medical Biotechnology, Poznan University of Medical Sciences, 61-866 Poznan, PolandAlthough progress is observed in cancer treatment, this disease continues to be the second leading cause of death worldwide. The current understanding of cancer indicates that treating cancer should not be limited to killing cancer cells alone, but that the target is the complex tumor microenvironment (TME). The application of nanoparticle-based drug delivery systems (DDS) can not only target cancer cells and TME, but also simultaneously resolve the severe side effects of various cancer treatment approaches, leading to more effective, precise, and less invasive therapy. Nanoparticles based on proteins derived from silkworms’ cocoons (like silk fibroin and sericins) and silk proteins from spiders (spidroins) are intensively explored not only in the oncology field. This natural-derived material offer biocompatibility, biodegradability, and simplicity of preparation methods. The protein-based material can be tailored for size, stability, drug loading/release kinetics, and functionalized with targeting ligands. This review summarizes the current status of drug delivery systems’ development based on proteins derived from silk fibroin, sericins, and spidroins, which application is focused on systemic cancer treatment. The nanoparticles that deliver chemotherapeutics, nucleic acid-based therapeutics, natural-derived agents, therapeutic proteins or peptides, inorganic compounds, as well as photosensitive molecules, are introduced.https://www.mdpi.com/1996-1944/13/21/4946silkparticlescancersilk fibroinspidroinsericin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anna Florczak Inga Grzechowiak Tomasz Deptuch Kamil Kucharczyk Alicja Kaminska Hanna Dams-Kozlowska |
spellingShingle |
Anna Florczak Inga Grzechowiak Tomasz Deptuch Kamil Kucharczyk Alicja Kaminska Hanna Dams-Kozlowska Silk Particles as Carriers of Therapeutic Molecules for Cancer Treatment Materials silk particles cancer silk fibroin spidroin sericin |
author_facet |
Anna Florczak Inga Grzechowiak Tomasz Deptuch Kamil Kucharczyk Alicja Kaminska Hanna Dams-Kozlowska |
author_sort |
Anna Florczak |
title |
Silk Particles as Carriers of Therapeutic Molecules for Cancer Treatment |
title_short |
Silk Particles as Carriers of Therapeutic Molecules for Cancer Treatment |
title_full |
Silk Particles as Carriers of Therapeutic Molecules for Cancer Treatment |
title_fullStr |
Silk Particles as Carriers of Therapeutic Molecules for Cancer Treatment |
title_full_unstemmed |
Silk Particles as Carriers of Therapeutic Molecules for Cancer Treatment |
title_sort |
silk particles as carriers of therapeutic molecules for cancer treatment |
publisher |
MDPI AG |
series |
Materials |
issn |
1996-1944 |
publishDate |
2020-11-01 |
description |
Although progress is observed in cancer treatment, this disease continues to be the second leading cause of death worldwide. The current understanding of cancer indicates that treating cancer should not be limited to killing cancer cells alone, but that the target is the complex tumor microenvironment (TME). The application of nanoparticle-based drug delivery systems (DDS) can not only target cancer cells and TME, but also simultaneously resolve the severe side effects of various cancer treatment approaches, leading to more effective, precise, and less invasive therapy. Nanoparticles based on proteins derived from silkworms’ cocoons (like silk fibroin and sericins) and silk proteins from spiders (spidroins) are intensively explored not only in the oncology field. This natural-derived material offer biocompatibility, biodegradability, and simplicity of preparation methods. The protein-based material can be tailored for size, stability, drug loading/release kinetics, and functionalized with targeting ligands. This review summarizes the current status of drug delivery systems’ development based on proteins derived from silk fibroin, sericins, and spidroins, which application is focused on systemic cancer treatment. The nanoparticles that deliver chemotherapeutics, nucleic acid-based therapeutics, natural-derived agents, therapeutic proteins or peptides, inorganic compounds, as well as photosensitive molecules, are introduced. |
topic |
silk particles cancer silk fibroin spidroin sericin |
url |
https://www.mdpi.com/1996-1944/13/21/4946 |
work_keys_str_mv |
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