Associations between Tissue Visfatin/Nicotinamide, Phosphoribosyltransferase (Nampt), Retinol Binding Protein-4, and Vaspin Concentrations and Insulin Resistance in Morbidly Obese Subjects
Visfatin/Nampt, vaspin, and retinol binding protein-4 (RBP-4) play an important role in insulin resistance. The objectives of this study were to measure visfatin/Nampt, vaspin, and RBP-4 concentrations in blood, liver, muscle, subcutaneous, omental, and mesenteric adipose tissues in morbidly obese s...
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Series: | Mediators of Inflammation |
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doaj-baa5affac8aa40a9b1a9ecfa043ec6802020-11-24T22:44:10ZengHindawi LimitedMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/861496861496Associations between Tissue Visfatin/Nicotinamide, Phosphoribosyltransferase (Nampt), Retinol Binding Protein-4, and Vaspin Concentrations and Insulin Resistance in Morbidly Obese SubjectsZeynep Goktas0Shannon Owens1Mallory Boylan2David Syn3Chwan-Li Shen4Debra B. Reed5Susan San Francisco6Shu Wang7Nutritional Sciences Program, College of Human Science, Texas Tech University, P.O. Box 41240, Lubbock, TX 79409-1240, USANutritional Sciences Program, College of Human Science, Texas Tech University, P.O. Box 41240, Lubbock, TX 79409-1240, USANutritional Sciences Program, College of Human Science, Texas Tech University, P.O. Box 41240, Lubbock, TX 79409-1240, USATexas Tech University Health Sciences Center, Lubbock, TX 79430, USADepartment of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USANutritional Sciences Program, College of Human Science, Texas Tech University, P.O. Box 41240, Lubbock, TX 79409-1240, USACenter for Biotechnology and Genomics, Texas Tech University, Lubbock, TX 79409, USANutritional Sciences Program, College of Human Science, Texas Tech University, P.O. Box 41240, Lubbock, TX 79409-1240, USAVisfatin/Nampt, vaspin, and retinol binding protein-4 (RBP-4) play an important role in insulin resistance. The objectives of this study were to measure visfatin/Nampt, vaspin, and RBP-4 concentrations in blood, liver, muscle, subcutaneous, omental, and mesenteric adipose tissues in morbidly obese subjects and investigate their relationship to insulin resistance. Blood and tissue samples were collected from 38 morbidly obese subjects during Roux-en-Y surgery. Insulin resistance biomarkers were measured using standard kits. Visfatin/Nampt, vaspin, and RBP-4 gene expression levels in tissues were measured using real-time PCR. Their protein concentrations in blood and tissues were measured using ELISA kits. Diabetic subjects had significantly higher homeostasis model of assessment-insulin resistance and age and lower blood HDL-cholesterol concentrations than nondiabetic and prediabetic subjects. Diabetic and prediabetic subjects had significantly higher blood concentrations of visfatin/Nampt and vaspin than nondiabetic subjects. Liver RBP-4 concentrations were positively associated with blood glucose concentrations. Blood insulin resistance biomarker levels were positively associated with visfatin/Nampt concentrations in omental adipose tissue and liver, and vaspin concentrations in mesenteric adipose tissue. In conclusion, the correlations of visfatin/Nampt, vaspin, and RBP-4 with insulin resistance are tissue dependent.http://dx.doi.org/10.1155/2013/861496 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zeynep Goktas Shannon Owens Mallory Boylan David Syn Chwan-Li Shen Debra B. Reed Susan San Francisco Shu Wang |
spellingShingle |
Zeynep Goktas Shannon Owens Mallory Boylan David Syn Chwan-Li Shen Debra B. Reed Susan San Francisco Shu Wang Associations between Tissue Visfatin/Nicotinamide, Phosphoribosyltransferase (Nampt), Retinol Binding Protein-4, and Vaspin Concentrations and Insulin Resistance in Morbidly Obese Subjects Mediators of Inflammation |
author_facet |
Zeynep Goktas Shannon Owens Mallory Boylan David Syn Chwan-Li Shen Debra B. Reed Susan San Francisco Shu Wang |
author_sort |
Zeynep Goktas |
title |
Associations between Tissue Visfatin/Nicotinamide, Phosphoribosyltransferase (Nampt), Retinol Binding Protein-4, and Vaspin Concentrations and Insulin Resistance in Morbidly Obese Subjects |
title_short |
Associations between Tissue Visfatin/Nicotinamide, Phosphoribosyltransferase (Nampt), Retinol Binding Protein-4, and Vaspin Concentrations and Insulin Resistance in Morbidly Obese Subjects |
title_full |
Associations between Tissue Visfatin/Nicotinamide, Phosphoribosyltransferase (Nampt), Retinol Binding Protein-4, and Vaspin Concentrations and Insulin Resistance in Morbidly Obese Subjects |
title_fullStr |
Associations between Tissue Visfatin/Nicotinamide, Phosphoribosyltransferase (Nampt), Retinol Binding Protein-4, and Vaspin Concentrations and Insulin Resistance in Morbidly Obese Subjects |
title_full_unstemmed |
Associations between Tissue Visfatin/Nicotinamide, Phosphoribosyltransferase (Nampt), Retinol Binding Protein-4, and Vaspin Concentrations and Insulin Resistance in Morbidly Obese Subjects |
title_sort |
associations between tissue visfatin/nicotinamide, phosphoribosyltransferase (nampt), retinol binding protein-4, and vaspin concentrations and insulin resistance in morbidly obese subjects |
publisher |
Hindawi Limited |
series |
Mediators of Inflammation |
issn |
0962-9351 1466-1861 |
publishDate |
2013-01-01 |
description |
Visfatin/Nampt, vaspin, and retinol binding protein-4 (RBP-4) play an important role in insulin resistance. The objectives of this study were to measure visfatin/Nampt, vaspin, and RBP-4 concentrations in blood, liver, muscle, subcutaneous, omental, and mesenteric adipose tissues in morbidly obese subjects and investigate their relationship to insulin resistance. Blood and tissue samples were collected from 38 morbidly obese subjects during Roux-en-Y surgery. Insulin resistance biomarkers were measured using standard kits. Visfatin/Nampt, vaspin, and RBP-4 gene expression levels in tissues were measured using real-time PCR. Their protein concentrations in blood and tissues were measured using ELISA kits. Diabetic subjects had significantly higher homeostasis model of assessment-insulin resistance and age and lower blood HDL-cholesterol concentrations than nondiabetic and prediabetic subjects. Diabetic and prediabetic subjects had significantly higher blood concentrations of visfatin/Nampt and vaspin than nondiabetic subjects. Liver RBP-4 concentrations were positively associated with blood glucose concentrations. Blood insulin resistance biomarker levels were positively associated with visfatin/Nampt concentrations in omental adipose tissue and liver, and vaspin concentrations in mesenteric adipose tissue. In conclusion, the correlations of visfatin/Nampt, vaspin, and RBP-4 with insulin resistance are tissue dependent. |
url |
http://dx.doi.org/10.1155/2013/861496 |
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