Epigenetic Alteration by DNA Promoter Hypermethylation of Genes Related to Transforming Growth Factor-β (TGF-β) Signaling in Cancer

Epigenetic Alteration by DNA Promoter Hypermethylation of Genes Related to Transforming Growth Factor-β (TGF-β) Signaling in Cancer

Epigenetic alterations in cancer, especially DNA methylation and histone modification, exert a significant effect on the deregulated expression of cancer-related genes and lay an epigenetic pathway to carcinogenesis and tumor progression. Global hypomethylation and local hypermethylation of CpG isla...

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Bibliographic Details
Main Authors: Kiyoshi Mori, Sohei Kitazawa, Ryuma Haraguchi, Masayo Fujimoto, Yuka Idei, Takeshi Kondo, Sann Sanda Khin, Riko Kitazawa
Format: Article
Language:English
Published: MDPI AG 2011-03-01
Series:Cancers
Subjects:
methylation
TGF-β signaling
cancer
Online Access:http://www.mdpi.com/2072-6694/3/1/982/

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