Optimization, characterization and evaluation of ZnO/polyvinylidene fluoride nanocomposites for orthopedic applications: improved antibacterial ability and promoted osteoblast growth
Herein, electrospun zinc oxide nanoparticle/poly (vinylidene fluoride) (ZnONP/PVDF) composite fiber membranes were designed, fabricated, and tested for improved orthopedic applications. A single factor screening study was conducted to determine the optimal ZnONP/PVDF formulation based on osteoblast...
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doaj-babc2184a5f246a0b52c51109005504a2021-07-06T11:30:11ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642020-01-012711378138510.1080/10717544.2020.18270841827084Optimization, characterization and evaluation of ZnO/polyvinylidene fluoride nanocomposites for orthopedic applications: improved antibacterial ability and promoted osteoblast growthYanhai Xi0Wenming Pan1Dan Xi2Xue Liu3Jiangmin Yu4Mintao Xue5Ning Xu6Jiankun Wen7Weiheng Wang8Hailong He9Yanyan Liu10Yue He11Chunjing Guo12Daquan Chen13Xiaojian Ye14Department of Spine Surgery, Changzheng Hospital, Second Military Medical UniversityDepartment of Spine Surgery, the Second People’s Hospital of ChangshuShandong Instutute for Product Quality InspectionSchool of Pharmacy, Yantai UniversityDepartment of Spine Surgery, Changzheng Hospital, Second Military Medical UniversityDepartment of Spine Surgery, Changzheng Hospital, Second Military Medical UniversityDepartment of Spine Surgery, Changzheng Hospital, Second Military Medical UniversityDepartment of Spine Surgery, Changzheng Hospital, Second Military Medical UniversityDepartment of Spine Surgery, Changzheng Hospital, Second Military Medical UniversityDepartment of Spine Surgery, Changzheng Hospital, Second Military Medical UniversityDepartment of Pharmaceutics, China Pharmaceutical UniversityDepartment of Pharmaceutics, China Pharmaceutical UniversitySchool of Pharmacy, Yantai UniversitySchool of Pharmacy, Yantai UniversityDepartment of Spine Surgery, Changzheng Hospital, Second Military Medical UniversityHerein, electrospun zinc oxide nanoparticle/poly (vinylidene fluoride) (ZnONP/PVDF) composite fiber membranes were designed, fabricated, and tested for improved orthopedic applications. A single factor screening study was conducted to determine the optimal ZnONP/PVDF formulation based on osteoblast (bone forming cells) proliferation and antibacterial properties. Further, ZnONP/PVDF materials were characterized for their morphology, crystallinity, roughness, piezoelectric properties, and chemistry to understand such cell results. The optimal concentration of high molecular weight PVDF (18%, w/v) and a low concentration of ZnONPs (1 mg/ml) were identified for electrospinning at room temperature in order to inhibit bacterial colonization (without resorting to antibiotic use) and promote osteoblast proliferation. Compared to no ZnO/PVDF scaffold without Piezo-excited group,the study showed that on the 1 mg/ml ZnO/PVDF scaffolds with piezo-excitation, the density of SA and E.coli decreased by 68% and 56%.The density of osteoblasts doubled within three days(compared to the control). In summary, ZnONP/PVDF composite fiber membranes were formulated by electrospinning showing an exceptional ability to eliminate bacteria colonization while at the same time promote osteoblast functions and, thus, they should be further studied for a wide range of orthopedic applications.http://dx.doi.org/10.1080/10717544.2020.1827084electrospinningzinc oxide/polyvinylidenenanoparticlesfluoride composite fiber membranepiezoelectricity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yanhai Xi Wenming Pan Dan Xi Xue Liu Jiangmin Yu Mintao Xue Ning Xu Jiankun Wen Weiheng Wang Hailong He Yanyan Liu Yue He Chunjing Guo Daquan Chen Xiaojian Ye |
spellingShingle |
Yanhai Xi Wenming Pan Dan Xi Xue Liu Jiangmin Yu Mintao Xue Ning Xu Jiankun Wen Weiheng Wang Hailong He Yanyan Liu Yue He Chunjing Guo Daquan Chen Xiaojian Ye Optimization, characterization and evaluation of ZnO/polyvinylidene fluoride nanocomposites for orthopedic applications: improved antibacterial ability and promoted osteoblast growth Drug Delivery electrospinning zinc oxide/polyvinylidene nanoparticles fluoride composite fiber membrane piezoelectricity |
author_facet |
Yanhai Xi Wenming Pan Dan Xi Xue Liu Jiangmin Yu Mintao Xue Ning Xu Jiankun Wen Weiheng Wang Hailong He Yanyan Liu Yue He Chunjing Guo Daquan Chen Xiaojian Ye |
author_sort |
Yanhai Xi |
title |
Optimization, characterization and evaluation of ZnO/polyvinylidene fluoride nanocomposites for orthopedic applications: improved antibacterial ability and promoted osteoblast growth |
title_short |
Optimization, characterization and evaluation of ZnO/polyvinylidene fluoride nanocomposites for orthopedic applications: improved antibacterial ability and promoted osteoblast growth |
title_full |
Optimization, characterization and evaluation of ZnO/polyvinylidene fluoride nanocomposites for orthopedic applications: improved antibacterial ability and promoted osteoblast growth |
title_fullStr |
Optimization, characterization and evaluation of ZnO/polyvinylidene fluoride nanocomposites for orthopedic applications: improved antibacterial ability and promoted osteoblast growth |
title_full_unstemmed |
Optimization, characterization and evaluation of ZnO/polyvinylidene fluoride nanocomposites for orthopedic applications: improved antibacterial ability and promoted osteoblast growth |
title_sort |
optimization, characterization and evaluation of zno/polyvinylidene fluoride nanocomposites for orthopedic applications: improved antibacterial ability and promoted osteoblast growth |
publisher |
Taylor & Francis Group |
series |
Drug Delivery |
issn |
1071-7544 1521-0464 |
publishDate |
2020-01-01 |
description |
Herein, electrospun zinc oxide nanoparticle/poly (vinylidene fluoride) (ZnONP/PVDF) composite fiber membranes were designed, fabricated, and tested for improved orthopedic applications. A single factor screening study was conducted to determine the optimal ZnONP/PVDF formulation based on osteoblast (bone forming cells) proliferation and antibacterial properties. Further, ZnONP/PVDF materials were characterized for their morphology, crystallinity, roughness, piezoelectric properties, and chemistry to understand such cell results. The optimal concentration of high molecular weight PVDF (18%, w/v) and a low concentration of ZnONPs (1 mg/ml) were identified for electrospinning at room temperature in order to inhibit bacterial colonization (without resorting to antibiotic use) and promote osteoblast proliferation. Compared to no ZnO/PVDF scaffold without Piezo-excited group,the study showed that on the 1 mg/ml ZnO/PVDF scaffolds with piezo-excitation, the density of SA and E.coli decreased by 68% and 56%.The density of osteoblasts doubled within three days(compared to the control). In summary, ZnONP/PVDF composite fiber membranes were formulated by electrospinning showing an exceptional ability to eliminate bacteria colonization while at the same time promote osteoblast functions and, thus, they should be further studied for a wide range of orthopedic applications. |
topic |
electrospinning zinc oxide/polyvinylidene nanoparticles fluoride composite fiber membrane piezoelectricity |
url |
http://dx.doi.org/10.1080/10717544.2020.1827084 |
work_keys_str_mv |
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