Retrieval-Induced Forgetting in a Pentylenetetrazole-Induced Epilepsy Model in the Rat

• Main Authors: Ahmad Almahozi, Maan Alsaaid, Saeed Bin Jabal, Amer Kamal
• Format: Article
• Language: English
• Published: MDPI AG 2018-12-01
• Series: Brain Sciences
• Subjects: retrieval-induced forgetting; epilepsy; kindling; pentylenetetrazole; inhibition; memory; rat; spontaneous object recognition
• Online Access: https://www.mdpi.com/2076-3425/8/12/215

The selective retrieval of some information may lead to the forgetting of related, but non-retrieved information. This memory phenomenon is termed retrieval-induced forgetting (RIF). Active inhibition is thought to function to resolve interference from competing information during retrieval, which results in forgetting. Epilepsy is associated with impaired inhibitory control that contributes to executive dysfunction. The purpose of this study is to investigate whether rats in a kindling model of epilepsy demonstrate normal levels of RIF. Rats were divided into two groups: saline and kindling. Pentylenetetrazole was injected intraperitoneally until the rats kindled. RIF was tested using a modified version of the spontaneous object recognition test, consisting of a sample phase, retrieval or interference phase, and a test phase. Exploration time for each object was analyzed. RIF was demonstrated in the saline group when rats subjected to the retrieval phase failed to discriminate between the familiar object and the novel object later in the test phase. Kindled rats, on the other hand, did not suffer forgetting even when they were subjected to the retrieval phase, as they spent significantly longer times exploring the novel rather than the familiar object in the test phase. Therefore, RIF was not observed in the kindling group. These findings indicate impaired retrieval-induced forgetting in kindled rats, which may be suggestive of a deficit in the inhibitory control of memory.