The Association Between Left Ventricular Hypertrophy and the Occurrence and Prognosis of Atrial Fibrillation: A Meta-Analysis

• Main Authors: Huaqiang Xiang, Yangjing Xue, Zhi Chen, Yongwei Yu, Yangpei Peng, Jinsheng Wang, Kangting Ji, Huifen Zhu
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2021-07-01
• Series: Frontiers in Cardiovascular Medicine
• Subjects: left ventricular hypertrophy; atrial fibrillation; predictor; prognosis; electrocardiogram
• Online Access: https://www.frontiersin.org/articles/10.3389/fcvm.2021.639993/full

Aims: The aim of this study was to perform a meta-analysis of studies of the association of left ventricular hypertrophy (LVH) and atrial fibrillation (AF), especially the predictive and prognostic role of LVH.Methods and Results: We searched Medline, Embase, and the Cochrane Library from inception through 10 April 2020. A total of 16 cohorts (133,091 individuals) were included. Compared with the normal subjects, patients with LVH were more susceptible to AF (RR = 1.46, 95% CI, 1.32–1.60). In patients with AF and LVH, there was a higher risk of all-cause mortality during 3.95 years (RR = 1.60, 95% CI, 1.42–1.79), and these patients were more likely to progress to persistent or paroxysmal AF (RR = 1.45, 95% CI, 1.20–1.76) than were patients without LVH. After catheter ablation of AF, patients with LVH were more likely to recur (RR = 1.58, 95% CI, 1.27–1.95).Conclusion: LVH is strongly associated with AF and has a negative impact on outcome in patients with AF.