Regulation of Eosinophil and Group 2 Innate Lymphoid Cell Trafficking in Asthma
Asthma is an inflammatory disease usually characterized by increased Type 2 cytokines and by an infiltration of eosinophils to the airways. While the production of Type 2 cytokines has been associated with TH2 lymphocytes, increasing evidence indicates that group 2 innate lymphoid cells (ILC2) play...
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doaj-bad02e5e7e7b47d0aa7b7d3c377d79d32020-11-24T22:58:55ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2017-08-01410.3389/fmed.2017.00136279376Regulation of Eosinophil and Group 2 Innate Lymphoid Cell Trafficking in AsthmaMarie-Chantal Larose0Anne-Sophie Archambault1Véronique Provost2Michel Laviolette3Nicolas Flamand4Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculté de Médecine, Département de Médecine, Université Laval, Québec City, QC, CanadaCentre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculté de Médecine, Département de Médecine, Université Laval, Québec City, QC, CanadaCentre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculté de Médecine, Département de Médecine, Université Laval, Québec City, QC, CanadaCentre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculté de Médecine, Département de Médecine, Université Laval, Québec City, QC, CanadaCentre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculté de Médecine, Département de Médecine, Université Laval, Québec City, QC, CanadaAsthma is an inflammatory disease usually characterized by increased Type 2 cytokines and by an infiltration of eosinophils to the airways. While the production of Type 2 cytokines has been associated with TH2 lymphocytes, increasing evidence indicates that group 2 innate lymphoid cells (ILC2) play an important role in the production of the Type 2 cytokines interleukin (IL)-5 and IL-13, which likely amplifies the recruitment of eosinophils from the blood to the airways. In that regard, recent asthma treatments have been focusing on blocking Type 2 cytokines, notably IL-4, IL-5, and IL-13. These treatments mainly result in decreased blood or sputum eosinophil counts as well as decreased asthma symptoms. This supports that therapies blocking eosinophil recruitment and activation are valuable tools in the management of asthma and its severity. Herein, we review the mechanisms involved in eosinophil and ILC2 recruitment to the airways, with an emphasis on eotaxins, other chemokines as well as their receptors. We also discuss the involvement of other chemoattractants, notably the bioactive lipids 5-oxo-eicosatetraenoic acid, prostaglandin D2, and 2-arachidonoyl-glycerol. Given that eosinophil biology differs between human and mice, we also highlight and discuss their responsiveness toward the different eosinophil chemoattractants.http://journal.frontiersin.org/article/10.3389/fmed.2017.00136/fulleosinophilgroup 2 innate lymphoid cells2-arachidonoyl-glycerolchemokineeotaxinasthma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marie-Chantal Larose Anne-Sophie Archambault Véronique Provost Michel Laviolette Nicolas Flamand |
spellingShingle |
Marie-Chantal Larose Anne-Sophie Archambault Véronique Provost Michel Laviolette Nicolas Flamand Regulation of Eosinophil and Group 2 Innate Lymphoid Cell Trafficking in Asthma Frontiers in Medicine eosinophil group 2 innate lymphoid cells 2-arachidonoyl-glycerol chemokine eotaxin asthma |
author_facet |
Marie-Chantal Larose Anne-Sophie Archambault Véronique Provost Michel Laviolette Nicolas Flamand |
author_sort |
Marie-Chantal Larose |
title |
Regulation of Eosinophil and Group 2 Innate Lymphoid Cell Trafficking in Asthma |
title_short |
Regulation of Eosinophil and Group 2 Innate Lymphoid Cell Trafficking in Asthma |
title_full |
Regulation of Eosinophil and Group 2 Innate Lymphoid Cell Trafficking in Asthma |
title_fullStr |
Regulation of Eosinophil and Group 2 Innate Lymphoid Cell Trafficking in Asthma |
title_full_unstemmed |
Regulation of Eosinophil and Group 2 Innate Lymphoid Cell Trafficking in Asthma |
title_sort |
regulation of eosinophil and group 2 innate lymphoid cell trafficking in asthma |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Medicine |
issn |
2296-858X |
publishDate |
2017-08-01 |
description |
Asthma is an inflammatory disease usually characterized by increased Type 2 cytokines and by an infiltration of eosinophils to the airways. While the production of Type 2 cytokines has been associated with TH2 lymphocytes, increasing evidence indicates that group 2 innate lymphoid cells (ILC2) play an important role in the production of the Type 2 cytokines interleukin (IL)-5 and IL-13, which likely amplifies the recruitment of eosinophils from the blood to the airways. In that regard, recent asthma treatments have been focusing on blocking Type 2 cytokines, notably IL-4, IL-5, and IL-13. These treatments mainly result in decreased blood or sputum eosinophil counts as well as decreased asthma symptoms. This supports that therapies blocking eosinophil recruitment and activation are valuable tools in the management of asthma and its severity. Herein, we review the mechanisms involved in eosinophil and ILC2 recruitment to the airways, with an emphasis on eotaxins, other chemokines as well as their receptors. We also discuss the involvement of other chemoattractants, notably the bioactive lipids 5-oxo-eicosatetraenoic acid, prostaglandin D2, and 2-arachidonoyl-glycerol. Given that eosinophil biology differs between human and mice, we also highlight and discuss their responsiveness toward the different eosinophil chemoattractants. |
topic |
eosinophil group 2 innate lymphoid cells 2-arachidonoyl-glycerol chemokine eotaxin asthma |
url |
http://journal.frontiersin.org/article/10.3389/fmed.2017.00136/full |
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