The DNA Sensor AIM2 Protects against Streptozotocin-Induced Type 1 Diabetes by Regulating Intestinal Homeostasis via the IL-18 Pathway

The DNA Sensor AIM2 Protects against Streptozotocin-Induced Type 1 Diabetes by Regulating Intestinal Homeostasis via the IL-18 Pathway

Pattern recognition receptors (PRRs), such as Nod2, Nlrp3, Tlr2, Trl4, and Tlr9, are directly involved in type 1 diabetes (T1D) susceptibility. However, the role of the cytosolic DNA sensor, AIM2, in T1D pathogenesis is still unknown. Here, we demonstrate that C57BL/6 mice lacking AIM2 (AIM2<sup&...

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Bibliographic Details
Main Authors: Jefferson Antônio Leite, Gabriela Pessenda, Isabel C. Guerra-Gomes, Alynne Karen Mendonça de Santana, Camila André Pereira, Frederico Ribeiro Campos Costa, Simone G. Ramos, Dario Simões Zamboni, Ana Maria Caetano Faria, Danilo Candido de Almeida, Niels Olsen Saraiva Câmara, Rita C. Tostes, João Santana Silva, Daniela Carlos
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
Innate immunity
AIM2 receptor
Type 1 diabetes
Online Access:https://www.mdpi.com/2073-4409/9/4/959

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