STUDY OF HEPATOPROTECTIVE ACTIVITY OF LIQUID EXTRACT OF SUMMER SAVORY HERB UNDER CONDITION OF TETRACHLOROMETHANE HEPATITIS
The aim of the work. It was carried out the investigation of the hepatoprotective activity of liquid extract of Summer Savory (Satureja hortensis L.) herb on a model of acute liver injury caused by carbon tetrachloride. Materials and Methods. The liquid extract was prepared by extracting the herb wi...
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doaj-bad6ec1d4c36419fad529179cd9cc1e12020-11-24T23:33:52ZengUkrmedknyha Publishing HouseФармацевтичний часопис2312-09672414-99262017-07-010210.11603/2312-0967.2017.2.78996997STUDY OF HEPATOPROTECTIVE ACTIVITY OF LIQUID EXTRACT OF SUMMER SAVORY HERB UNDER CONDITION OF TETRACHLOROMETHANE HEPATITISM. I. Shanaida0O. M. Oleshchuk1P. H. Lykhatskyi2I. Z. Kernychna3Тернопільський державний медичний університет, ТернопільТернопільський державний медичний університет, ТернопільТернопільський державний медичний університет, ТернопільТернопільський державний медичний університет, ТернопільThe aim of the work. It was carried out the investigation of the hepatoprotective activity of liquid extract of Summer Savory (Satureja hortensis L.) herb on a model of acute liver injury caused by carbon tetrachloride. Materials and Methods. The liquid extract was prepared by extracting the herb with ethanol (70 %, 50 % and 30 %), followed by combining and concentrating these extracts; its dosage was carried out according to the dry residue. It was twice administered the 50 % tetrachloromethane solution at a dose of 1 ml/kg of body weight of rats for induction of hepatitis. Doses of 50 mg/kg, 100 mg/kg and 200 mg/kg of the liquid extract were chosen for studying of their hepatoprotective activity; «Silibor» was used as a reference drug in a dose of 50 mg/kg. Results and Discussion.Using of the liquid extract of Summer Savory herb with preventive maintenance against the tetrachloromethane hepatitis in rats signifi cantly reduced the general manifestations of intoxication. All rats after receiving the extract have survived, and it can indicate the prospect of hepatoprotective activity of investigated extract. The most signifi cant changes of biochemical parameters set by using the extract at a dose of 200 mg/kg. Investigated extract at dose 200 mg/kg did not signifi cantly differ from the reference drug according to infi uence on the content of malonic dialdehyde, molecules of average weight and the coefficient of liver mass. It prevailed over the «Silibor» by such biochemical parameters as the content of total protein and superoxide dismutase. Using of 50 mg kg and 100 mg/kg doses did not always have a normalizing effect on data of affected animals.Conclusions. This study determined the hepatoprotective effect of Summer Savory liquid extract at the dose of 200 mg/kg after administration to tetrachloromethane-affected rats.https://ojs.tdmu.edu.ua/index.php/pharm-chas/article/view/7899тетрахлорметановий гепатитрідкий екстрактSatureja hortensis. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
M. I. Shanaida O. M. Oleshchuk P. H. Lykhatskyi I. Z. Kernychna |
spellingShingle |
M. I. Shanaida O. M. Oleshchuk P. H. Lykhatskyi I. Z. Kernychna STUDY OF HEPATOPROTECTIVE ACTIVITY OF LIQUID EXTRACT OF SUMMER SAVORY HERB UNDER CONDITION OF TETRACHLOROMETHANE HEPATITIS Фармацевтичний часопис тетрахлорметановий гепатит рідкий екстракт Satureja hortensis. |
author_facet |
M. I. Shanaida O. M. Oleshchuk P. H. Lykhatskyi I. Z. Kernychna |
author_sort |
M. I. Shanaida |
title |
STUDY OF HEPATOPROTECTIVE ACTIVITY OF LIQUID EXTRACT OF SUMMER SAVORY HERB UNDER CONDITION OF TETRACHLOROMETHANE HEPATITIS |
title_short |
STUDY OF HEPATOPROTECTIVE ACTIVITY OF LIQUID EXTRACT OF SUMMER SAVORY HERB UNDER CONDITION OF TETRACHLOROMETHANE HEPATITIS |
title_full |
STUDY OF HEPATOPROTECTIVE ACTIVITY OF LIQUID EXTRACT OF SUMMER SAVORY HERB UNDER CONDITION OF TETRACHLOROMETHANE HEPATITIS |
title_fullStr |
STUDY OF HEPATOPROTECTIVE ACTIVITY OF LIQUID EXTRACT OF SUMMER SAVORY HERB UNDER CONDITION OF TETRACHLOROMETHANE HEPATITIS |
title_full_unstemmed |
STUDY OF HEPATOPROTECTIVE ACTIVITY OF LIQUID EXTRACT OF SUMMER SAVORY HERB UNDER CONDITION OF TETRACHLOROMETHANE HEPATITIS |
title_sort |
study of hepatoprotective activity of liquid extract of summer savory herb under condition of tetrachloromethane hepatitis |
publisher |
Ukrmedknyha Publishing House |
series |
Фармацевтичний часопис |
issn |
2312-0967 2414-9926 |
publishDate |
2017-07-01 |
description |
The aim of the work. It was carried out the investigation of the hepatoprotective activity of liquid extract of Summer Savory (Satureja hortensis L.) herb on a model of acute liver injury caused by carbon tetrachloride.
Materials and Methods. The liquid extract was prepared by extracting the herb with ethanol (70 %, 50 % and 30 %), followed by combining and concentrating these extracts; its dosage was carried out according to the dry residue. It was twice administered the 50 % tetrachloromethane solution at a dose of 1 ml/kg of body weight of rats for induction of hepatitis. Doses of 50 mg/kg, 100 mg/kg and 200 mg/kg of the liquid extract were chosen for studying of their hepatoprotective activity; «Silibor» was used as a reference drug in a dose of 50 mg/kg.
Results and Discussion.Using of the liquid extract of Summer Savory herb with preventive maintenance against the tetrachloromethane hepatitis in rats signifi cantly reduced the general manifestations of intoxication. All rats after receiving the extract have survived, and it can indicate the prospect of hepatoprotective activity of investigated extract. The most signifi cant changes of biochemical parameters set by using the extract at a dose of 200 mg/kg. Investigated extract at dose 200 mg/kg did not signifi cantly differ from the reference drug according to infi uence on the content of malonic dialdehyde, molecules of average weight and the coefficient of liver mass. It prevailed over the «Silibor» by such biochemical parameters as the content of total protein and superoxide dismutase. Using of 50 mg kg and 100 mg/kg doses did not always have a normalizing effect on data of affected animals.Conclusions. This study determined the hepatoprotective effect of Summer Savory liquid extract at the dose of 200 mg/kg after administration to tetrachloromethane-affected rats. |
topic |
тетрахлорметановий гепатит рідкий екстракт Satureja hortensis. |
url |
https://ojs.tdmu.edu.ua/index.php/pharm-chas/article/view/7899 |
work_keys_str_mv |
AT mishanaida studyofhepatoprotectiveactivityofliquidextractofsummersavoryherbunderconditionoftetrachloromethanehepatitis AT omoleshchuk studyofhepatoprotectiveactivityofliquidextractofsummersavoryherbunderconditionoftetrachloromethanehepatitis AT phlykhatskyi studyofhepatoprotectiveactivityofliquidextractofsummersavoryherbunderconditionoftetrachloromethanehepatitis AT izkernychna studyofhepatoprotectiveactivityofliquidextractofsummersavoryherbunderconditionoftetrachloromethanehepatitis |
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