STUDY OF HEPATOPROTECTIVE ACTIVITY OF LIQUID EXTRACT OF SUMMER SAVORY HERB UNDER CONDITION OF TETRACHLOROMETHANE HEPATITIS

• Main Authors: M. I. Shanaida, O. M. Oleshchuk, P. H. Lykhatskyi, I. Z. Kernychna
• Format: Article
• Language: English
• Published: Ukrmedknyha Publishing House 2017-07-01
• Series: Фармацевтичний часопис
• Subjects: тетрахлорметановий гепатит; рідкий екстракт; Satureja hortensis.
• Online Access: https://ojs.tdmu.edu.ua/index.php/pharm-chas/article/view/7899

The aim of the work. It was carried out the investigation of the hepatoprotective activity of liquid extract of Summer Savory (Satureja hortensis L.) herb on a model of acute liver injury caused by carbon tetrachloride. Materials and Methods. The liquid extract was prepared by extracting the herb with ethanol (70 %, 50 % and 30 %), followed by combining and concentrating these extracts; its dosage was carried out according to the dry residue. It was twice administered the 50 % tetrachloromethane solution at a dose of 1 ml/kg of body weight of rats for induction of hepatitis. Doses of 50 mg/kg, 100 mg/kg and 200 mg/kg of the liquid extract were chosen for studying of their hepatoprotective activity; «Silibor» was used as a reference drug in a dose of 50 mg/kg. Results and Discussion.Using of the liquid extract of Summer Savory herb with preventive maintenance against the tetrachloromethane hepatitis in rats signifi cantly reduced the general manifestations of intoxication. All rats after receiving the extract have survived, and it can indicate the prospect of hepatoprotective activity of investigated extract. The most signifi cant changes of biochemical parameters set by using the extract at a dose of 200 mg/kg. Investigated extract at dose 200 mg/kg did not signifi cantly differ from the reference drug according to infi uence on the content of malonic dialdehyde, molecules of average weight and the coefficient of liver mass. It prevailed over the «Silibor» by such biochemical parameters as the content of total protein and superoxide dismutase. Using of 50 mg kg and 100 mg/kg doses did not always have a normalizing effect on data of affected animals.Conclusions. This study determined the hepatoprotective effect of Summer Savory liquid extract at the dose of 200 mg/kg after administration to tetrachloromethane-affected rats.