Differential pre-mRNA splicing regulates Nnat isoforms in the hypothalamus after gastric bypass surgery in mice.

Differential pre-mRNA splicing regulates Nnat isoforms in the hypothalamus after gastric bypass surgery in mice.

Neuronatin (NNAT) is an endoplasmic reticulum proteolipid implicated in intracellular signalling. Nnat is highly-expressed in the hypothalamus, where it is acutely regulated by nutrients and leptin. Nnat pre-mRNA is differentially spliced to create Nnat-α and -β isoforms. Genetic variation of NNAT i...

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Bibliographic Details
Main Authors: William R Scott, Cigdem Gelegen, Keval Chandarana, Efthimia Karra, Ahmed Yousseif, Chloé Amouyal, Agharul I Choudhury, Fabrizio Andreelli, Dominic J Withers, Rachel L Batterham
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3603916?pdf=render

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