Cost-minimization analysis of individually tailored or fixed-scheduled rituximab maintenance therapy for antineutrophil-cytoplasm antibody associated vasculitides
Objective: Patients included in MAINRITSAN2 trial received either an individually tailored or a fixed-schedule therapy with rituximab as maintenance treatment of antineutrophil cytoplasm antibody associated vasculitides. The aim of this study was to compare the real-world costs of both arms. Meth...
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doaj-badeda3e759c4cadb6224e5f83b536d32020-11-25T02:34:56ZengGrupo Aula MédicaFarmacia Hospitalaria1130-63432171-86952020-03-01442465010.7399/fh.11287Cost-minimization analysis of individually tailored or fixed-scheduled rituximab maintenance therapy for antineutrophil-cytoplasm antibody associated vasculitidesAna Belén Guisado-Gil0Marina Muñoz-Burgos1Ana Ortega-Eslava2Francisco Javier García-Hernández3Bernardo Santos-Ramos4Pharmacy Service, Hospital Universitario Virgen del Rocío, Sevilla. SpainPharmacy Service, Hospital Universitario Virgen del Rocío, Sevilla. SpainPharmacy Service, Clínica Universidad de Navarra, Pamplona (Navarra). SpainInternal Medicine Service, Hospital Universitario Virgen del Rocío, Sevilla. SpainPharmacy Service, Hospital Universitario Virgen del Rocío, Sevilla. SpainObjective: Patients included in MAINRITSAN2 trial received either an individually tailored or a fixed-schedule therapy with rituximab as maintenance treatment of antineutrophil cytoplasm antibody associated vasculitides. The aim of this study was to compare the real-world costs of both arms. Method: We performed a cost-minimization analysis over an 18-month time period, estimating direct costs –drug acquisition, preparation, administration and monitoring costs– from the health system perspective. We conducted a number of additional sensitivity analyses with different assumptions for unit costs, with further scenarios including the interquartile range of the tailored-infusion group results, different number of monitoring visits for fixed-schedule regimen and different number of reported severe adverse events. A cost- effectiveness analysis was conducted as a sensitivity analysis using the absolute difference in the relapse rate and its confidence interval. Results: The individually tailored maintenance therapy with rituximab was shown to be a cost-saving treatment compared to the fixed-schedule therapy (6,049 euros vs. 7,850 euros). Savings resulted primarily from lower drug acquisition costs (2,861 vs. 4,768 euros) and lower preparation and administration costs (892 vs. 1,486 euros), due to the lower number of infusions per patient in the tailored-infusion regimen. The tailoredinfusion regimen presented higher monitoring costs (2,296 vs. 1,596 euros). This result was replicated in all assumptions considered in the sensitivity analysis of cost-minimization approach. Conclusions: From the perspective of the health system, the tailoredtherapy regimen seems to be the preferable option in terms of direct costs. Further studies assessing all the effects and costs associated to vasculitides maintenance treatment with rituximab are needed to support clinical management and healthcare planning. http://www.aulamedica.es/fh/pdf/11287.pdfrituximabantibodiesantineutrophil cytoplasmicanca associated vasculitidespharmacoeconomy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana Belén Guisado-Gil Marina Muñoz-Burgos Ana Ortega-Eslava Francisco Javier García-Hernández Bernardo Santos-Ramos |
spellingShingle |
Ana Belén Guisado-Gil Marina Muñoz-Burgos Ana Ortega-Eslava Francisco Javier García-Hernández Bernardo Santos-Ramos Cost-minimization analysis of individually tailored or fixed-scheduled rituximab maintenance therapy for antineutrophil-cytoplasm antibody associated vasculitides Farmacia Hospitalaria rituximab antibodies antineutrophil cytoplasmic anca associated vasculitides pharmacoeconomy |
author_facet |
Ana Belén Guisado-Gil Marina Muñoz-Burgos Ana Ortega-Eslava Francisco Javier García-Hernández Bernardo Santos-Ramos |
author_sort |
Ana Belén Guisado-Gil |
title |
Cost-minimization analysis of individually tailored or fixed-scheduled rituximab maintenance therapy for antineutrophil-cytoplasm antibody associated vasculitides |
title_short |
Cost-minimization analysis of individually tailored or fixed-scheduled rituximab maintenance therapy for antineutrophil-cytoplasm antibody associated vasculitides |
title_full |
Cost-minimization analysis of individually tailored or fixed-scheduled rituximab maintenance therapy for antineutrophil-cytoplasm antibody associated vasculitides |
title_fullStr |
Cost-minimization analysis of individually tailored or fixed-scheduled rituximab maintenance therapy for antineutrophil-cytoplasm antibody associated vasculitides |
title_full_unstemmed |
Cost-minimization analysis of individually tailored or fixed-scheduled rituximab maintenance therapy for antineutrophil-cytoplasm antibody associated vasculitides |
title_sort |
cost-minimization analysis of individually tailored or fixed-scheduled rituximab maintenance therapy for antineutrophil-cytoplasm antibody associated vasculitides |
publisher |
Grupo Aula Médica |
series |
Farmacia Hospitalaria |
issn |
1130-6343 2171-8695 |
publishDate |
2020-03-01 |
description |
Objective: Patients included in MAINRITSAN2 trial received either an individually tailored or a fixed-schedule therapy with rituximab as maintenance treatment of antineutrophil cytoplasm antibody associated vasculitides. The aim of this study was to compare the real-world costs of both arms.
Method: We performed a cost-minimization analysis over an 18-month time period, estimating direct costs –drug acquisition, preparation, administration and monitoring costs– from the health system perspective. We conducted a number of additional sensitivity analyses with different assumptions for unit costs, with further scenarios including the interquartile range of the tailored-infusion group results, different number of monitoring visits for fixed-schedule regimen and different number of reported severe adverse events. A cost- effectiveness analysis was conducted as a sensitivity analysis using the absolute difference in the relapse rate and its confidence interval.
Results: The individually tailored maintenance therapy with rituximab was shown to be a cost-saving treatment compared to the fixed-schedule therapy (6,049 euros vs. 7,850 euros). Savings resulted primarily from lower drug acquisition costs (2,861 vs. 4,768 euros) and lower preparation and administration costs (892 vs. 1,486 euros), due to the lower number of infusions per patient in the tailored-infusion regimen. The tailoredinfusion regimen presented higher monitoring costs (2,296 vs. 1,596 euros). This result was replicated in all assumptions considered in the sensitivity analysis of cost-minimization approach.
Conclusions: From the perspective of the health system, the tailoredtherapy regimen seems to be the preferable option in terms of direct costs. Further studies assessing all the effects and costs associated to vasculitides maintenance treatment with rituximab are needed to support clinical management and healthcare planning.
|
topic |
rituximab antibodies antineutrophil cytoplasmic anca associated vasculitides pharmacoeconomy |
url |
http://www.aulamedica.es/fh/pdf/11287.pdf |
work_keys_str_mv |
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