Current status and role of programmed ventricular stimulation in patients without sustained ventricular arrhythmias and reduced ejection fraction: Analysis of the Japan cardiac device treatment registry database
Abstract Background The aim of this study was to clarify the current status and role of programmed ventricular stimulation in patients without sustained ventricular arrhythmias and reduced left ventricular ejection fraction (LVEF). Methods The follow‐up data of the Japan cardiac device treatment reg...
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doaj-bae3c78ae623483680014e4dbe12e4472021-03-06T06:11:15ZengWileyJournal of Arrhythmia1880-42761883-21482021-02-0137114815610.1002/joa3.12468Current status and role of programmed ventricular stimulation in patients without sustained ventricular arrhythmias and reduced ejection fraction: Analysis of the Japan cardiac device treatment registry databaseHisashi Yokoshiki0Akihiko Shimizu1Takeshi Mitsuhashi2Kohei Ishibashi3Tomoyuki Kabutoya4Yasuhiro Yoshiga5Ritsuko Kohno6Haruhiko Abe7Akihiko Nogami8Members of the Implantable Cardioverter‐Defibrillator (ICD) Committee of the Japanese Heart Rhythm SocietyDepartment of Cardiovascular Medicine Sapporo City General Hospital Sapporo JapanUBE Kohsan Central Hospital Upe JapanDepartment of Cardiovascular Medicine Hoshi General Hospital Koriyama JapanDepartment of Cardiovascular Medicine National Cerebral and Cardiovascular Center Suita JapanDivision of Cardiovascular Medicine Department of Medicine Jichi Medical University School of Medicine Shimotsuke JapanDivision of Cardiology Department of Medicine and Clinical Science Yamaguchi University Graduate School of Medicine Ube JapanDepartment of Heart Rhythm Management University of Occupational & Environmental Health Kitakyushu JapanDepartment of Heart Rhythm Management University of Occupational & Environmental Health Kitakyushu JapanCardiovascular Division Faculty of Medicine University of Tsukuba Tsukuba JapanAbstract Background The aim of this study was to clarify the current status and role of programmed ventricular stimulation in patients without sustained ventricular arrhythmias and reduced left ventricular ejection fraction (LVEF). Methods The follow‐up data of the Japan cardiac device treatment registry (JCDTR) was analyzed in 746 patients with LVEF ≦35% and no prior history of sustained ventricular arrhythmias who underwent de novo implantable cardioverter‐defibrillator (ICD) or cardiac resynchronization therapy with a defibrillator (CRT‐D) implantation between January 2011 and August 2015. Results Electrophysiological study (EPS) with programmed ventricular stimulation had been performed before the device implant in 118 patients (15.8%, EPS group). During the mean follow‐up of 21 ± 12 months, the rate of freedom from any death and appropriate defibrillator therapy was not significantly different between EPS group (n = 118) and No EPS group (n = 628). NYHA class II‐IV, and QRS duration were negatively associated with performing EPS. Among patients in the EPS group, the rate of ventricular tachycardia (VT)/ventricular fibrillation (VF) induction was 48%. The inducibility was not a predictor of appropriate defibrillator therapy, whereas BNP ≧535 pg/mL and no use of amiodarone were significantly associated with a risk of the appropriate therapy. Conclusion EPS for induction of VT/VF had been performed in about 16% of patients with reduced LVEF before primary prevention ICD/CRT‐D implantation. Elevated BNP levels and no use of amiodarone, but not inducibility of VT/VF, appeared to be associated with appropriate defibrillator therapy in these populations.https://doi.org/10.1002/joa3.12468cardiac resynchronization therapy with a defibrillator (CRT‐D)electrophysiological study (EPS)implantable cardioverter‐defibrillator (ICD)primary preventionventricular fibrillation (VF)ventricular tachycardia (VT) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hisashi Yokoshiki Akihiko Shimizu Takeshi Mitsuhashi Kohei Ishibashi Tomoyuki Kabutoya Yasuhiro Yoshiga Ritsuko Kohno Haruhiko Abe Akihiko Nogami Members of the Implantable Cardioverter‐Defibrillator (ICD) Committee of the Japanese Heart Rhythm Society |
spellingShingle |
Hisashi Yokoshiki Akihiko Shimizu Takeshi Mitsuhashi Kohei Ishibashi Tomoyuki Kabutoya Yasuhiro Yoshiga Ritsuko Kohno Haruhiko Abe Akihiko Nogami Members of the Implantable Cardioverter‐Defibrillator (ICD) Committee of the Japanese Heart Rhythm Society Current status and role of programmed ventricular stimulation in patients without sustained ventricular arrhythmias and reduced ejection fraction: Analysis of the Japan cardiac device treatment registry database Journal of Arrhythmia cardiac resynchronization therapy with a defibrillator (CRT‐D) electrophysiological study (EPS) implantable cardioverter‐defibrillator (ICD) primary prevention ventricular fibrillation (VF) ventricular tachycardia (VT) |
author_facet |
Hisashi Yokoshiki Akihiko Shimizu Takeshi Mitsuhashi Kohei Ishibashi Tomoyuki Kabutoya Yasuhiro Yoshiga Ritsuko Kohno Haruhiko Abe Akihiko Nogami Members of the Implantable Cardioverter‐Defibrillator (ICD) Committee of the Japanese Heart Rhythm Society |
author_sort |
Hisashi Yokoshiki |
title |
Current status and role of programmed ventricular stimulation in patients without sustained ventricular arrhythmias and reduced ejection fraction: Analysis of the Japan cardiac device treatment registry database |
title_short |
Current status and role of programmed ventricular stimulation in patients without sustained ventricular arrhythmias and reduced ejection fraction: Analysis of the Japan cardiac device treatment registry database |
title_full |
Current status and role of programmed ventricular stimulation in patients without sustained ventricular arrhythmias and reduced ejection fraction: Analysis of the Japan cardiac device treatment registry database |
title_fullStr |
Current status and role of programmed ventricular stimulation in patients without sustained ventricular arrhythmias and reduced ejection fraction: Analysis of the Japan cardiac device treatment registry database |
title_full_unstemmed |
Current status and role of programmed ventricular stimulation in patients without sustained ventricular arrhythmias and reduced ejection fraction: Analysis of the Japan cardiac device treatment registry database |
title_sort |
current status and role of programmed ventricular stimulation in patients without sustained ventricular arrhythmias and reduced ejection fraction: analysis of the japan cardiac device treatment registry database |
publisher |
Wiley |
series |
Journal of Arrhythmia |
issn |
1880-4276 1883-2148 |
publishDate |
2021-02-01 |
description |
Abstract Background The aim of this study was to clarify the current status and role of programmed ventricular stimulation in patients without sustained ventricular arrhythmias and reduced left ventricular ejection fraction (LVEF). Methods The follow‐up data of the Japan cardiac device treatment registry (JCDTR) was analyzed in 746 patients with LVEF ≦35% and no prior history of sustained ventricular arrhythmias who underwent de novo implantable cardioverter‐defibrillator (ICD) or cardiac resynchronization therapy with a defibrillator (CRT‐D) implantation between January 2011 and August 2015. Results Electrophysiological study (EPS) with programmed ventricular stimulation had been performed before the device implant in 118 patients (15.8%, EPS group). During the mean follow‐up of 21 ± 12 months, the rate of freedom from any death and appropriate defibrillator therapy was not significantly different between EPS group (n = 118) and No EPS group (n = 628). NYHA class II‐IV, and QRS duration were negatively associated with performing EPS. Among patients in the EPS group, the rate of ventricular tachycardia (VT)/ventricular fibrillation (VF) induction was 48%. The inducibility was not a predictor of appropriate defibrillator therapy, whereas BNP ≧535 pg/mL and no use of amiodarone were significantly associated with a risk of the appropriate therapy. Conclusion EPS for induction of VT/VF had been performed in about 16% of patients with reduced LVEF before primary prevention ICD/CRT‐D implantation. Elevated BNP levels and no use of amiodarone, but not inducibility of VT/VF, appeared to be associated with appropriate defibrillator therapy in these populations. |
topic |
cardiac resynchronization therapy with a defibrillator (CRT‐D) electrophysiological study (EPS) implantable cardioverter‐defibrillator (ICD) primary prevention ventricular fibrillation (VF) ventricular tachycardia (VT) |
url |
https://doi.org/10.1002/joa3.12468 |
work_keys_str_mv |
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