Beneficial effects of Panax ginseng for the treatment and prevention of neurodegenerative diseases: past findings and future directions
In recent years, several therapeutic drugs have been rationally designed and synthesized based on the novel knowledge gained from investigating the actions of biologically active chemicals derived from foods, plants, and medicinal herbs. One of the major advantages of these naturalistic chemicals is...
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doaj-baf8eb78be9e4fe79af44d9ac00339cb2020-11-24T21:40:38ZengElsevierJournal of Ginseng Research1226-84532018-07-01423239247Beneficial effects of Panax ginseng for the treatment and prevention of neurodegenerative diseases: past findings and future directionsKi Hyun Kim0Dahae Lee1Hye Lim Lee2Chang-Eop Kim3Kiwon Jung4Ki Sung Kang5School of Pharmacy, Sungkyunkwan University, Suwon, Republic of KoreaSchool of Pharmacy, Sungkyunkwan University, Suwon, Republic of KoreaCollege of Korean Medicine, Gachon University, Seongnam, Republic of KoreaCollege of Korean Medicine, Gachon University, Seongnam, Republic of KoreaInstitute of Pharmaceutical Sciences, College of Pharmacy, CHA University, Sungnam, Republic of Korea; Corresponding authors. Institute of Pharmaceutical Sciences, College of Pharmacy, CHA University, Sungnam 13844, Korea (K. Jung). College of Korean Medicine, Gachon University, Seongnam 13120, Korea (K.S. Kang)College of Korean Medicine, Gachon University, Seongnam, Republic of Korea; Corresponding authors. Institute of Pharmaceutical Sciences, College of Pharmacy, CHA University, Sungnam 13844, Korea (K. Jung). College of Korean Medicine, Gachon University, Seongnam 13120, Korea (K.S. Kang)In recent years, several therapeutic drugs have been rationally designed and synthesized based on the novel knowledge gained from investigating the actions of biologically active chemicals derived from foods, plants, and medicinal herbs. One of the major advantages of these naturalistic chemicals is their ability to interact with multiple targets in the body resulting in a combined beneficial effect. Ginseng is a perennial herb (Araliaceae family), a species within the genus Panax, and a highly valued and popular medicinal plant. Evidence for the medicinal and health benefits of Panax ginseng and its components in preventing neurodegeneration has increased significantly in the past decade. The beneficial effects of P. ginseng on neurodegenerative diseases have been attributed primarily to the antioxidative and immunomodulatory activities of its ginsenoside components. Mechanistic studies on the neuroprotective effects of ginsenosides revealed that they act not only as antioxidants but also as modulators of intracellular neuronal signaling and metabolism, cell survival/death genes, and mitochondrial function. The goal of the present paper is to provide a brief review of recent knowledge and developments concerning the beneficial effects as well as the mechanism of action of P. ginseng and its components in the treatment and prevention of neurodegenerative diseases. Keywords: antioxidant, ginsenosides, neurodegenerative diseases, Panax ginsenghttp://www.sciencedirect.com/science/article/pii/S122684531630269X |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ki Hyun Kim Dahae Lee Hye Lim Lee Chang-Eop Kim Kiwon Jung Ki Sung Kang |
spellingShingle |
Ki Hyun Kim Dahae Lee Hye Lim Lee Chang-Eop Kim Kiwon Jung Ki Sung Kang Beneficial effects of Panax ginseng for the treatment and prevention of neurodegenerative diseases: past findings and future directions Journal of Ginseng Research |
author_facet |
Ki Hyun Kim Dahae Lee Hye Lim Lee Chang-Eop Kim Kiwon Jung Ki Sung Kang |
author_sort |
Ki Hyun Kim |
title |
Beneficial effects of Panax ginseng for the treatment and prevention of neurodegenerative diseases: past findings and future directions |
title_short |
Beneficial effects of Panax ginseng for the treatment and prevention of neurodegenerative diseases: past findings and future directions |
title_full |
Beneficial effects of Panax ginseng for the treatment and prevention of neurodegenerative diseases: past findings and future directions |
title_fullStr |
Beneficial effects of Panax ginseng for the treatment and prevention of neurodegenerative diseases: past findings and future directions |
title_full_unstemmed |
Beneficial effects of Panax ginseng for the treatment and prevention of neurodegenerative diseases: past findings and future directions |
title_sort |
beneficial effects of panax ginseng for the treatment and prevention of neurodegenerative diseases: past findings and future directions |
publisher |
Elsevier |
series |
Journal of Ginseng Research |
issn |
1226-8453 |
publishDate |
2018-07-01 |
description |
In recent years, several therapeutic drugs have been rationally designed and synthesized based on the novel knowledge gained from investigating the actions of biologically active chemicals derived from foods, plants, and medicinal herbs. One of the major advantages of these naturalistic chemicals is their ability to interact with multiple targets in the body resulting in a combined beneficial effect. Ginseng is a perennial herb (Araliaceae family), a species within the genus Panax, and a highly valued and popular medicinal plant. Evidence for the medicinal and health benefits of Panax ginseng and its components in preventing neurodegeneration has increased significantly in the past decade. The beneficial effects of P. ginseng on neurodegenerative diseases have been attributed primarily to the antioxidative and immunomodulatory activities of its ginsenoside components. Mechanistic studies on the neuroprotective effects of ginsenosides revealed that they act not only as antioxidants but also as modulators of intracellular neuronal signaling and metabolism, cell survival/death genes, and mitochondrial function. The goal of the present paper is to provide a brief review of recent knowledge and developments concerning the beneficial effects as well as the mechanism of action of P. ginseng and its components in the treatment and prevention of neurodegenerative diseases. Keywords: antioxidant, ginsenosides, neurodegenerative diseases, Panax ginseng |
url |
http://www.sciencedirect.com/science/article/pii/S122684531630269X |
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