Comparison of the Propofol-Remifentanil and Desflurane-Remifentanil in Target-Controlled Infusion
INTRODUCTION[|]Our objective was to examine the clinical properties of two anesthetic regimens, propofol-remifentanil target-controlled infusion (TCI) or desflurane-remifentanil TCI under bispectral index (BIS) guidance during lower abdominal surgery procedures.[¤]METHODS[|]Sixty consenting patients...
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doaj-bafc0ad0d8954a0abc9d7d55870104072021-01-24T18:11:54ZengKARE PublishingSouthern Clinics of Istanbul Eurasia2587-09982020-06-0131214615110.14744/scie.2020.15870SCIE-15870Comparison of the Propofol-Remifentanil and Desflurane-Remifentanil in Target-Controlled InfusionÖzlem Sezen0Gülten Arslan1Department of Anesthesiology and Reanimation, University of Health Sciences, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, TurkeyDepartment of Anesthesiology and Reanimation, University of Health Sciences, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, TurkeyINTRODUCTION[|]Our objective was to examine the clinical properties of two anesthetic regimens, propofol-remifentanil target-controlled infusion (TCI) or desflurane-remifentanil TCI under bispectral index (BIS) guidance during lower abdominal surgery procedures.[¤]METHODS[|]Sixty consenting patients who scheduled for lower abdominal surgery were prospectively studied and were included in one of the two groups: propofol-remifentanil group (Group P) or desflurane-remifentanil group (Group D). General anaesthesia was induced with 2 mg kg-1 propofol, 1 µ kg-1 remifentanil and 0.6 mg kg-1 rocuronium injection. After intubation, remifentanil was administered using the TCI device in both groups. The pharmacokinetic model of Minto was used. Group D patients received a 50%–50% oxygen-air mixture and 6% desflurane. The Schnider model was selected for the administration of propofol 1% (10 mg/mL) in Group P, and the TCI dose was adjusted to 4/mL-1. The propofol infusion and inspired fraction of desflurane were adjusted to keep BIS value between 40–60. Hemodynamic parameters, time until recovery of spontaneous respiration, eye-opening and tracheal extubation, compliance with verbal commands, duration of anesthesia and surgery and postoperative modified Aldrete scores were recorded for all patients.[¤]RESULTS[|]The heart rate (p=0.006), diastolic arterial pressure (p=0.003) and mean arterial pressure (p<0.0001) for the Group P was significantly higher than Group D. The extubation time was shorter in Group P (p=0.02), but there was no significant difference between the groups concerning other recovery findings.[¤]DISCUSSION AND CONCLUSION[|]BIS-guided combinations of propofol-remifentanil and desflurane-remifentanil delivered using TCI are both suitable for patients undergoing lower abdominal surgery. The low blood pressure achieved with target-controlled infusions of remifentanil and desflurane may confer important advantages.[¤]https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-15870bispectral indexdesflurane; propofol; remifentanil; target-controlled infusion. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Özlem Sezen Gülten Arslan |
spellingShingle |
Özlem Sezen Gülten Arslan Comparison of the Propofol-Remifentanil and Desflurane-Remifentanil in Target-Controlled Infusion Southern Clinics of Istanbul Eurasia bispectral index desflurane; propofol; remifentanil; target-controlled infusion. |
author_facet |
Özlem Sezen Gülten Arslan |
author_sort |
Özlem Sezen |
title |
Comparison of the Propofol-Remifentanil and Desflurane-Remifentanil in Target-Controlled Infusion |
title_short |
Comparison of the Propofol-Remifentanil and Desflurane-Remifentanil in Target-Controlled Infusion |
title_full |
Comparison of the Propofol-Remifentanil and Desflurane-Remifentanil in Target-Controlled Infusion |
title_fullStr |
Comparison of the Propofol-Remifentanil and Desflurane-Remifentanil in Target-Controlled Infusion |
title_full_unstemmed |
Comparison of the Propofol-Remifentanil and Desflurane-Remifentanil in Target-Controlled Infusion |
title_sort |
comparison of the propofol-remifentanil and desflurane-remifentanil in target-controlled infusion |
publisher |
KARE Publishing |
series |
Southern Clinics of Istanbul Eurasia |
issn |
2587-0998 |
publishDate |
2020-06-01 |
description |
INTRODUCTION[|]Our objective was to examine the clinical properties of two anesthetic regimens, propofol-remifentanil target-controlled infusion (TCI) or desflurane-remifentanil TCI under bispectral index (BIS) guidance during lower abdominal surgery procedures.[¤]METHODS[|]Sixty consenting patients who scheduled for lower abdominal surgery were prospectively studied and were included in one of the two groups: propofol-remifentanil group (Group P) or desflurane-remifentanil group (Group D). General anaesthesia was induced with 2 mg kg-1 propofol, 1 µ kg-1 remifentanil and 0.6 mg kg-1 rocuronium injection. After intubation, remifentanil was administered using the TCI device in both groups. The pharmacokinetic model of Minto was used. Group D patients received a 50%–50% oxygen-air mixture and 6% desflurane. The Schnider model was selected for the administration of propofol 1% (10 mg/mL) in Group P, and the TCI dose was adjusted to 4/mL-1. The propofol infusion and inspired fraction of desflurane were adjusted to keep BIS value between 40–60. Hemodynamic parameters, time until recovery of spontaneous respiration, eye-opening and tracheal extubation, compliance with verbal commands, duration of anesthesia and surgery and postoperative modified Aldrete scores were recorded for all patients.[¤]RESULTS[|]The heart rate (p=0.006), diastolic arterial pressure (p=0.003) and mean arterial pressure (p<0.0001) for the Group P was significantly higher than Group D. The extubation time was shorter in Group P (p=0.02), but there was no significant difference between the groups concerning other recovery findings.[¤]DISCUSSION AND CONCLUSION[|]BIS-guided combinations of propofol-remifentanil and desflurane-remifentanil delivered using TCI are both suitable for patients undergoing lower abdominal surgery. The low blood pressure achieved with target-controlled infusions of remifentanil and desflurane may confer important advantages.[¤] |
topic |
bispectral index desflurane; propofol; remifentanil; target-controlled infusion. |
url |
https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-15870 |
work_keys_str_mv |
AT ozlemsezen comparisonofthepropofolremifentanilanddesfluraneremifentanilintargetcontrolledinfusion AT gultenarslan comparisonofthepropofolremifentanilanddesfluraneremifentanilintargetcontrolledinfusion |
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