Lens thickness assessment: anterior segment optical coherence tomography versus A-scan ultrasonography
AIM: To assess lens thickness measurements with anterior segment-optical coherence tomography (AS-OCT) in comparison with A-scan ultrasonography (A-scan US). METHODS: There were 218 adult subjects (218 eyes) aged 59.2±9.2y enrolled in this prospective cross-sectional study. Forty-three eyes had o...
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doaj-bb113bc1481146e284c251bcbef82c682020-11-24T23:48:50ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982015-12-01861151115510.3980/j.issn.2222-3959.2015.06.13Lens thickness assessment: anterior segment optical coherence tomography versus A-scan ultrasonographyNikoo Hamzeh0Sasan Moghimi1Golshan Latifi2Massood Mohammadi3Nassim Khatibi4Shan C. Lin5Tehran University of Medical Science, Farabi Eye Hospital, Tehran 13336, IranTehran University of Medical Science, Farabi Eye Hospital, Tehran 13336, Iran; Koret Vision Center, San Francisco Medical School, University of California, San Francisco, CA 94143, USATehran University of Medical Science, Farabi Eye Hospital, Tehran 13336, IranTehran University of Medical Science, Farabi Eye Hospital, Tehran 13336, IranTehran University of Medical Science, Farabi Eye Hospital, Tehran 13336, IranKoret Vision Center, San Francisco Medical School, University of California, San Francisco, CA 94143, USAAIM: To assess lens thickness measurements with anterior segment-optical coherence tomography (AS-OCT) in comparison with A-scan ultrasonography (A-scan US). METHODS: There were 218 adult subjects (218 eyes) aged 59.2±9.2y enrolled in this prospective cross-sectional study. Forty-three eyes had open angles and 175 eyes had narrow angles. Routine ophthalmic exam was performed and nuclear opacity was graded using the Lens Opacities Classification System III (LOCS III). Lens thickness was measured by AS-OCT (Visante OCT, Carl Zeiss Meditec, Dublin, CA, USA). The highest quality image was selected for each eye and lens thickness was calculated using ImageJ software. Lens thickness was also measured by A-scan US. RESULTS: Interclass correlations showed a value of 99.7% for intra-visit measurements and 95.3% for inter-visit measurements. The mean lens thickness measured by AS-OCT was not significantly different from that of A-scan US (4.861±0.404 vs 4.866±0.351 mm, P=0.74). Lens thickness values obtained from the two instruments were highly correlated overall (Pearson correlation coefficient=0.81, P<0.001), and in all LOCS III specific subgroups except in grade 5 of nuclear opacity. Bland-Altman analysis revealed a 95% limit of agreement from -0.45 to 0.46 mm. Lens thickness difference between the two instruments became smaller as the lens thickness increased and AS-OCT yielded smaller values than A-scan US in thicker lens (β=-0.29, P<0.001) CONCLUSION: AS-OCT-derived lens thickness measurement is valid and comparable to the results obtained by A-scan US. It can be used as a reliable noncontact method for measuring lens thickness in adults with or without significant cataract.http://www.ijo.cn/en_publish/2015/6/20150613.pdflens thicknessA-scan ultrasonographyanterior segment-optical coherence tomographybiometrycataract |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nikoo Hamzeh Sasan Moghimi Golshan Latifi Massood Mohammadi Nassim Khatibi Shan C. Lin |
spellingShingle |
Nikoo Hamzeh Sasan Moghimi Golshan Latifi Massood Mohammadi Nassim Khatibi Shan C. Lin Lens thickness assessment: anterior segment optical coherence tomography versus A-scan ultrasonography International Journal of Ophthalmology lens thickness A-scan ultrasonography anterior segment-optical coherence tomography biometry cataract |
author_facet |
Nikoo Hamzeh Sasan Moghimi Golshan Latifi Massood Mohammadi Nassim Khatibi Shan C. Lin |
author_sort |
Nikoo Hamzeh |
title |
Lens thickness assessment: anterior segment optical coherence tomography versus A-scan ultrasonography |
title_short |
Lens thickness assessment: anterior segment optical coherence tomography versus A-scan ultrasonography |
title_full |
Lens thickness assessment: anterior segment optical coherence tomography versus A-scan ultrasonography |
title_fullStr |
Lens thickness assessment: anterior segment optical coherence tomography versus A-scan ultrasonography |
title_full_unstemmed |
Lens thickness assessment: anterior segment optical coherence tomography versus A-scan ultrasonography |
title_sort |
lens thickness assessment: anterior segment optical coherence tomography versus a-scan ultrasonography |
publisher |
Press of International Journal of Ophthalmology (IJO PRESS) |
series |
International Journal of Ophthalmology |
issn |
2222-3959 2227-4898 |
publishDate |
2015-12-01 |
description |
AIM: To assess lens thickness measurements with anterior segment-optical coherence tomography (AS-OCT) in comparison with A-scan ultrasonography (A-scan US).
METHODS: There were 218 adult subjects (218 eyes) aged 59.2±9.2y enrolled in this prospective cross-sectional study. Forty-three eyes had open angles and 175 eyes had narrow angles. Routine ophthalmic exam was performed and nuclear opacity was graded using the Lens Opacities Classification System III (LOCS III). Lens thickness was measured by AS-OCT (Visante OCT, Carl Zeiss Meditec, Dublin, CA, USA). The highest quality image was selected for each eye and lens thickness was calculated using ImageJ software. Lens thickness was also measured by A-scan US.
RESULTS: Interclass correlations showed a value of 99.7% for intra-visit measurements and 95.3% for inter-visit measurements. The mean lens thickness measured by AS-OCT was not significantly different from that of A-scan US (4.861±0.404 vs 4.866±0.351 mm, P=0.74). Lens thickness values obtained from the two instruments were highly correlated overall (Pearson correlation coefficient=0.81, P<0.001), and in all LOCS III specific subgroups except in grade 5 of nuclear opacity. Bland-Altman analysis revealed a 95% limit of agreement from -0.45 to 0.46 mm. Lens thickness difference between the two instruments became smaller as the lens thickness increased and AS-OCT yielded smaller values than A-scan US in thicker lens (β=-0.29, P<0.001)
CONCLUSION: AS-OCT-derived lens thickness measurement is valid and comparable to the results obtained by A-scan US. It can be used as a reliable noncontact method for measuring lens thickness in adults with or without significant cataract. |
topic |
lens thickness A-scan ultrasonography anterior segment-optical coherence tomography biometry cataract |
url |
http://www.ijo.cn/en_publish/2015/6/20150613.pdf |
work_keys_str_mv |
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