Immunization of Cats against Fel d 1 Results in Reduced Allergic Symptoms of Owners
An innovative approach was tested to treat cat allergy in humans by vaccinating cats with Fel-CuMV (HypoCat<sup>TM</sup>), a vaccine against the major cat allergen Fel d 1 based on virus-like particles derived from cucumber mosaic virus (CuMV-VLPs). Upon vaccination, cats develop neutral...
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doaj-bb1e4fe0915445ec86463168b95f3fa32020-11-25T00:40:43ZengMDPI AGViruses1999-49152020-03-0112328810.3390/v12030288v12030288Immunization of Cats against Fel d 1 Results in Reduced Allergic Symptoms of OwnersFranziska Thoms0Stefanie Haas1Aline Erhart2Claudia S. Nett3Silvia Rüfenacht4Nicole Graf5Arnis Strods6Gauravraj Patil7Thonur Leenadevi8Michael C. Fontaine9Lindsey A. Toon10Gary T. Jennings11Gabriela Senti12Thomas M. Kündig13Martin F. Bachmann14Department of Dermatology, Zurich University Hospital, Wagistrasse 12, 8952 Schlieren/Zurich, SwitzerlandDepartment of Dermatology, Zurich University Hospital, Wagistrasse 12, 8952 Schlieren/Zurich, SwitzerlandClinical Trials Center Zurich, University Hospital Zurich, Moussonstrasse 2, 8044 Zurich, Switzerlandvetderm.ch, Ennetseeklink für Kleintiere, Rothusstrasse 2, 6331 Hünenberg, SwitzerlanddermaVet, Tierklinik Aarau West AG, Muhenstrasse 56, 5036 Oberentfelden, SwitzerlandGraf Biostatistics, Amelenweg 5, 8400 Winterthur, SwitzerlandBenchmark Animal Health, Benchmark Holdings Plc, 8 Smithy Wood Dr, Sheffield S35 1QN, UKBenchmark Animal Health, Benchmark Holdings Plc, 8 Smithy Wood Dr, Sheffield S35 1QN, UKBenchmark Animal Health, Benchmark Holdings Plc, 8 Smithy Wood Dr, Sheffield S35 1QN, UKBenchmark Animal Health, Benchmark Holdings Plc, 8 Smithy Wood Dr, Sheffield S35 1QN, UKBenchmark Animal Health, Benchmark Holdings Plc, 8 Smithy Wood Dr, Sheffield S35 1QN, UKDepartment of Dermatology, Zurich University Hospital, Wagistrasse 12, 8952 Schlieren/Zurich, SwitzerlandDirector Research and Education, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, SwitzerlandDepartment of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091 Zurich, SwitzerlandDepartment of Immunology, Inselspital, University of Bern, Salihaus 2, 3007 Bern, SwitzerlandAn innovative approach was tested to treat cat allergy in humans by vaccinating cats with Fel-CuMV (HypoCat<sup>TM</sup>), a vaccine against the major cat allergen Fel d 1 based on virus-like particles derived from cucumber mosaic virus (CuMV-VLPs). Upon vaccination, cats develop neutralizing antibodies against the allergen Fel d 1, which reduces the level of reactive allergen, thus lowering the symptoms or even preventing allergic reactions in humans. The combined methodological field study included ten cat-allergic participants who lived together with their cats (<i>n</i> = 13), that were immunized with Fel-CuMV. The aim was to determine methods for measuring a change in allergic symptoms. A home-based provocation test (petting time and organ specific symptom score (OSSS)) and a general weekly (or monthly) symptom score (G(W)SS) were used to assess changes in allergic symptoms. The petting time until a pre-defined level of allergic symptoms was reached increased already early after vaccination of the cats and was apparent over the course of the study. In addition, the OSSS after provocation and G(W)SS recorded a persistent reduction in symptoms over the study period and could serve for long-term assessment. Hence, the immunization of cats with HypoCat<sup>TM</sup> (Fel-CuMV) may have a positive impact on the cat allergy of the owner, and changes could be assessed by the provocation test as well as G(W)SS.https://www.mdpi.com/1999-4915/12/3/288cat allergyvaccinationfel d 1hypocat™virus-like particle |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Franziska Thoms Stefanie Haas Aline Erhart Claudia S. Nett Silvia Rüfenacht Nicole Graf Arnis Strods Gauravraj Patil Thonur Leenadevi Michael C. Fontaine Lindsey A. Toon Gary T. Jennings Gabriela Senti Thomas M. Kündig Martin F. Bachmann |
spellingShingle |
Franziska Thoms Stefanie Haas Aline Erhart Claudia S. Nett Silvia Rüfenacht Nicole Graf Arnis Strods Gauravraj Patil Thonur Leenadevi Michael C. Fontaine Lindsey A. Toon Gary T. Jennings Gabriela Senti Thomas M. Kündig Martin F. Bachmann Immunization of Cats against Fel d 1 Results in Reduced Allergic Symptoms of Owners Viruses cat allergy vaccination fel d 1 hypocat™ virus-like particle |
author_facet |
Franziska Thoms Stefanie Haas Aline Erhart Claudia S. Nett Silvia Rüfenacht Nicole Graf Arnis Strods Gauravraj Patil Thonur Leenadevi Michael C. Fontaine Lindsey A. Toon Gary T. Jennings Gabriela Senti Thomas M. Kündig Martin F. Bachmann |
author_sort |
Franziska Thoms |
title |
Immunization of Cats against Fel d 1 Results in Reduced Allergic Symptoms of Owners |
title_short |
Immunization of Cats against Fel d 1 Results in Reduced Allergic Symptoms of Owners |
title_full |
Immunization of Cats against Fel d 1 Results in Reduced Allergic Symptoms of Owners |
title_fullStr |
Immunization of Cats against Fel d 1 Results in Reduced Allergic Symptoms of Owners |
title_full_unstemmed |
Immunization of Cats against Fel d 1 Results in Reduced Allergic Symptoms of Owners |
title_sort |
immunization of cats against fel d 1 results in reduced allergic symptoms of owners |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2020-03-01 |
description |
An innovative approach was tested to treat cat allergy in humans by vaccinating cats with Fel-CuMV (HypoCat<sup>TM</sup>), a vaccine against the major cat allergen Fel d 1 based on virus-like particles derived from cucumber mosaic virus (CuMV-VLPs). Upon vaccination, cats develop neutralizing antibodies against the allergen Fel d 1, which reduces the level of reactive allergen, thus lowering the symptoms or even preventing allergic reactions in humans. The combined methodological field study included ten cat-allergic participants who lived together with their cats (<i>n</i> = 13), that were immunized with Fel-CuMV. The aim was to determine methods for measuring a change in allergic symptoms. A home-based provocation test (petting time and organ specific symptom score (OSSS)) and a general weekly (or monthly) symptom score (G(W)SS) were used to assess changes in allergic symptoms. The petting time until a pre-defined level of allergic symptoms was reached increased already early after vaccination of the cats and was apparent over the course of the study. In addition, the OSSS after provocation and G(W)SS recorded a persistent reduction in symptoms over the study period and could serve for long-term assessment. Hence, the immunization of cats with HypoCat<sup>TM</sup> (Fel-CuMV) may have a positive impact on the cat allergy of the owner, and changes could be assessed by the provocation test as well as G(W)SS. |
topic |
cat allergy vaccination fel d 1 hypocat™ virus-like particle |
url |
https://www.mdpi.com/1999-4915/12/3/288 |
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