Spread Through Air Spaces (STAS) in Lung Cancer: A Multiple-Perspective and Update Review

Meng Jia, Shili Yu, Hongwen Gao, Ping-Li Sun Department of Pathology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of ChinaCorrespondence: Ping-Li Sun Tel +86 431-81136833Email pinglisun@naver.comBackground: Spread through air spaces (STAS) is a spreading ph...

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Main Authors: Jia M, Yu S, Gao H, Sun PL
Format: Article
Language:English
Published: Dove Medical Press 2020-04-01
Series:Cancer Management and Research
Subjects:
Online Access:https://www.dovepress.com/spread-through-air-spaces-stas-in-lung-cancer-a-multiple-perspective-a-peer-reviewed-article-CMAR
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spelling doaj-bb25e560605f408f87a73af874a51d5c2020-11-25T02:38:04ZengDove Medical PressCancer Management and Research1179-13222020-04-01Volume 122743275253257Spread Through Air Spaces (STAS) in Lung Cancer: A Multiple-Perspective and Update ReviewJia MYu SGao HSun PLMeng Jia, Shili Yu, Hongwen Gao, Ping-Li Sun Department of Pathology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of ChinaCorrespondence: Ping-Li Sun Tel +86 431-81136833Email pinglisun@naver.comBackground: Spread through air spaces (STAS) is a spreading phenomenon of lung cancers, which is defined as tumor cells within air spaces in the lung parenchyma beyond the edge of the main tumor. To date, several articles have reviewed the studies concerning the significance of STAS; however, most articles focused on the prognosis without summarizing the significance of STAS on other aspects. In this review, we comprehensively summarized the current literature related to STAS, so as to explore the clinical significance of STAS from multiple perspectives.Main Body: This section provided a comprehensive overview of the significance of STAS from multiple perspectives and summarized current controversies and challenges in the diagnosis and clinical application.Conclusion: STAS is a conspicuous spreading phenomenon of lung cancers indicating worse prognosis; nevertheless, the treatment strategy for patients with STAS remains to be discussed. Further studies are needed to elaborate whether a STAS-positive patient who underwent limited resection needs a second operation or postoperative adjuvant treatment. Meanwhile, the internal mechanism of STAS formation is largely undiscovered. Whether the capability of detachment-migration-reattachment in STAS tumor cells is achieved at the time of primary tumorigenesis or in the progress of tumor development needs to be studied, and the related signal pathways or genetic alterations need to be explored. With this information, it may be possible to improve the prognosis of patients with STAS-positive lung cancers.Keywords: spread through air spaces, non-small cell lung cancer, adenocarcinoma, squamous cell carcinomahttps://www.dovepress.com/spread-through-air-spaces-stas-in-lung-cancer-a-multiple-perspective-a-peer-reviewed-article-CMARspread through air spacesnon-small cell lung canceradenocarcinomasquamous cell carcinoma
collection DOAJ
language English
format Article
sources DOAJ
author Jia M
Yu S
Gao H
Sun PL
spellingShingle Jia M
Yu S
Gao H
Sun PL
Spread Through Air Spaces (STAS) in Lung Cancer: A Multiple-Perspective and Update Review
Cancer Management and Research
spread through air spaces
non-small cell lung cancer
adenocarcinoma
squamous cell carcinoma
author_facet Jia M
Yu S
Gao H
Sun PL
author_sort Jia M
title Spread Through Air Spaces (STAS) in Lung Cancer: A Multiple-Perspective and Update Review
title_short Spread Through Air Spaces (STAS) in Lung Cancer: A Multiple-Perspective and Update Review
title_full Spread Through Air Spaces (STAS) in Lung Cancer: A Multiple-Perspective and Update Review
title_fullStr Spread Through Air Spaces (STAS) in Lung Cancer: A Multiple-Perspective and Update Review
title_full_unstemmed Spread Through Air Spaces (STAS) in Lung Cancer: A Multiple-Perspective and Update Review
title_sort spread through air spaces (stas) in lung cancer: a multiple-perspective and update review
publisher Dove Medical Press
series Cancer Management and Research
issn 1179-1322
publishDate 2020-04-01
description Meng Jia, Shili Yu, Hongwen Gao, Ping-Li Sun Department of Pathology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of ChinaCorrespondence: Ping-Li Sun Tel +86 431-81136833Email pinglisun@naver.comBackground: Spread through air spaces (STAS) is a spreading phenomenon of lung cancers, which is defined as tumor cells within air spaces in the lung parenchyma beyond the edge of the main tumor. To date, several articles have reviewed the studies concerning the significance of STAS; however, most articles focused on the prognosis without summarizing the significance of STAS on other aspects. In this review, we comprehensively summarized the current literature related to STAS, so as to explore the clinical significance of STAS from multiple perspectives.Main Body: This section provided a comprehensive overview of the significance of STAS from multiple perspectives and summarized current controversies and challenges in the diagnosis and clinical application.Conclusion: STAS is a conspicuous spreading phenomenon of lung cancers indicating worse prognosis; nevertheless, the treatment strategy for patients with STAS remains to be discussed. Further studies are needed to elaborate whether a STAS-positive patient who underwent limited resection needs a second operation or postoperative adjuvant treatment. Meanwhile, the internal mechanism of STAS formation is largely undiscovered. Whether the capability of detachment-migration-reattachment in STAS tumor cells is achieved at the time of primary tumorigenesis or in the progress of tumor development needs to be studied, and the related signal pathways or genetic alterations need to be explored. With this information, it may be possible to improve the prognosis of patients with STAS-positive lung cancers.Keywords: spread through air spaces, non-small cell lung cancer, adenocarcinoma, squamous cell carcinoma
topic spread through air spaces
non-small cell lung cancer
adenocarcinoma
squamous cell carcinoma
url https://www.dovepress.com/spread-through-air-spaces-stas-in-lung-cancer-a-multiple-perspective-a-peer-reviewed-article-CMAR
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