The Temporal Propagation of Intrinsic Brain Activity Associate With the Occurrence of PTSD
The abnormal brain activity is a pivotal condition for the occurrence of posttraumatic stress disorder. However, the dynamic time features of intrinsic brain activities still remain unclearly in PTSD patients. Our study aims to perform the resting-state lag analysis (RS-LA) method to explore potenti...
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doaj-bb2a2e8adfd44fd2938dee036fe5d6832020-11-25T01:06:43ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402018-05-01910.3389/fpsyt.2018.00218348137The Temporal Propagation of Intrinsic Brain Activity Associate With the Occurrence of PTSDYifei Weng0Rongfeng Qi1Feng Chen2Jun Ke3Jun Ke4Qiang Xu5Yuan Zhong6Lida Chen7Jianjun Li8Zhiqiang Zhang9Li Zhang10Guangming Lu11Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Radiology, People's Hospital of Hainan Province, Haikou, ChinaDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Radiology, The First Affiliated Hospital of Suzhou University, Suzhou, ChinaDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaKey Laboratory of Psychiatry and Mental Health of Hunan Province, Mental Health Institute, Second Xiangya Hospital, National Technology Institute of Psychiatry, Central South University, Changsha, ChinaDepartment of Radiology, People's Hospital of Hainan Province, Haikou, ChinaDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaKey Laboratory of Psychiatry and Mental Health of Hunan Province, Mental Health Institute, Second Xiangya Hospital, National Technology Institute of Psychiatry, Central South University, Changsha, ChinaDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaThe abnormal brain activity is a pivotal condition for the occurrence of posttraumatic stress disorder. However, the dynamic time features of intrinsic brain activities still remain unclearly in PTSD patients. Our study aims to perform the resting-state lag analysis (RS-LA) method to explore potential propagated patterns of intrinsic brain activities in PTSD patients. We recruited 27 drug-naive patients with PTSD, 33 trauma-exposed controls (TEC), and 30 demographically matched healthy controls (HC) in the final data statistics. Both RS-LA and conventional voxel-wise functional connectivity strength (FCS) methods were employed on the same dataset. Then, Spearman correlation analysis was conducted on time latency values of those abnormal brain regions with the clinical assessments. Compared with HC group, the time latency patterns of PTSD patients significantly shifted toward later in posterior cingulate cortex/precuneus, middle prefrontal cortex, right angular, and left pre- and post-central cortex. The TEC group tended to have similar time latency in right angular. Additionally, significant time latency in right STG was found in PTSD group relative to TEC group. Spearman correlation analysis revealed that the time latency value of mPFC negatively correlated to the PTSD checklist-civilian version scores (PCL_C) in PTSD group (r = −0.578, P < 0.05). Furthermore, group differences map of FCS exhibited parts of overlapping areas with that of RS-LA, however, less specificity in detecting PTSD patients. In conclusion, apparent alterations of time latency were observed in DMN and primary sensorimotor areas of PTSD patients. These findings provide us with new evidence to explain the neural pathophysiology contributing to PTSD.https://www.frontiersin.org/article/10.3389/fpsyt.2018.00218/fullposttraumatic stress disorderresting-state fMRIlag mappingfunctional connectivity strengthdynamics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yifei Weng Rongfeng Qi Feng Chen Jun Ke Jun Ke Qiang Xu Yuan Zhong Lida Chen Jianjun Li Zhiqiang Zhang Li Zhang Guangming Lu |
spellingShingle |
Yifei Weng Rongfeng Qi Feng Chen Jun Ke Jun Ke Qiang Xu Yuan Zhong Lida Chen Jianjun Li Zhiqiang Zhang Li Zhang Guangming Lu The Temporal Propagation of Intrinsic Brain Activity Associate With the Occurrence of PTSD Frontiers in Psychiatry posttraumatic stress disorder resting-state fMRI lag mapping functional connectivity strength dynamics |
author_facet |
Yifei Weng Rongfeng Qi Feng Chen Jun Ke Jun Ke Qiang Xu Yuan Zhong Lida Chen Jianjun Li Zhiqiang Zhang Li Zhang Guangming Lu |
author_sort |
Yifei Weng |
title |
The Temporal Propagation of Intrinsic Brain Activity Associate With the Occurrence of PTSD |
title_short |
The Temporal Propagation of Intrinsic Brain Activity Associate With the Occurrence of PTSD |
title_full |
The Temporal Propagation of Intrinsic Brain Activity Associate With the Occurrence of PTSD |
title_fullStr |
The Temporal Propagation of Intrinsic Brain Activity Associate With the Occurrence of PTSD |
title_full_unstemmed |
The Temporal Propagation of Intrinsic Brain Activity Associate With the Occurrence of PTSD |
title_sort |
temporal propagation of intrinsic brain activity associate with the occurrence of ptsd |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychiatry |
issn |
1664-0640 |
publishDate |
2018-05-01 |
description |
The abnormal brain activity is a pivotal condition for the occurrence of posttraumatic stress disorder. However, the dynamic time features of intrinsic brain activities still remain unclearly in PTSD patients. Our study aims to perform the resting-state lag analysis (RS-LA) method to explore potential propagated patterns of intrinsic brain activities in PTSD patients. We recruited 27 drug-naive patients with PTSD, 33 trauma-exposed controls (TEC), and 30 demographically matched healthy controls (HC) in the final data statistics. Both RS-LA and conventional voxel-wise functional connectivity strength (FCS) methods were employed on the same dataset. Then, Spearman correlation analysis was conducted on time latency values of those abnormal brain regions with the clinical assessments. Compared with HC group, the time latency patterns of PTSD patients significantly shifted toward later in posterior cingulate cortex/precuneus, middle prefrontal cortex, right angular, and left pre- and post-central cortex. The TEC group tended to have similar time latency in right angular. Additionally, significant time latency in right STG was found in PTSD group relative to TEC group. Spearman correlation analysis revealed that the time latency value of mPFC negatively correlated to the PTSD checklist-civilian version scores (PCL_C) in PTSD group (r = −0.578, P < 0.05). Furthermore, group differences map of FCS exhibited parts of overlapping areas with that of RS-LA, however, less specificity in detecting PTSD patients. In conclusion, apparent alterations of time latency were observed in DMN and primary sensorimotor areas of PTSD patients. These findings provide us with new evidence to explain the neural pathophysiology contributing to PTSD. |
topic |
posttraumatic stress disorder resting-state fMRI lag mapping functional connectivity strength dynamics |
url |
https://www.frontiersin.org/article/10.3389/fpsyt.2018.00218/full |
work_keys_str_mv |
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