LZerD Protein-Protein Docking Webserver Enhanced With de novo Structure Prediction
Protein-protein docking is a useful tool for modeling the structures of protein complexes that have yet to be experimentally determined. Understanding the structures of protein complexes is a key component for formulating hypotheses in biophysics regarding the functional mechanisms of complexes. Pro...
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2021-08-01
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doaj-bb2e816fcd3244cca0302a11b1e39e422021-08-12T09:55:36ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-08-01810.3389/fmolb.2021.724947724947LZerD Protein-Protein Docking Webserver Enhanced With de novo Structure PredictionCharles Christoffer0Vijay Bharadwaj1Ryan Luu2Daisuke Kihara3Daisuke Kihara4Department of Computer Science, Purdue University, West Lafayette, IN, United StatesDepartment of Computer Science, Purdue University, West Lafayette, IN, United StatesDepartment of Computer Science, Purdue University, West Lafayette, IN, United StatesDepartment of Computer Science, Purdue University, West Lafayette, IN, United StatesDepartment of Biological Sciences, Purdue University, West Lafayette, IN, United StatesProtein-protein docking is a useful tool for modeling the structures of protein complexes that have yet to be experimentally determined. Understanding the structures of protein complexes is a key component for formulating hypotheses in biophysics regarding the functional mechanisms of complexes. Protein-protein docking is an established technique for cases where the structures of the subunits have been determined. While the number of known structures deposited in the Protein Data Bank is increasing, there are still many cases where the structures of individual proteins that users want to dock are not determined yet. Here, we have integrated the AttentiveDist method for protein structure prediction into our LZerD webserver for protein-protein docking, which enables users to simply submit protein sequences and obtain full-complex atomic models, without having to supply any structure themselves. We have further extended the LZerD docking interface with a symmetrical homodimer mode. The LZerD server is available at https://lzerd.kiharalab.org/.https://www.frontiersin.org/articles/10.3389/fmolb.2021.724947/fullweb serverLZerDstructure modelingprotein bioinformaticsprotein-protein dockingprotein structure prediction |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Charles Christoffer Vijay Bharadwaj Ryan Luu Daisuke Kihara Daisuke Kihara |
spellingShingle |
Charles Christoffer Vijay Bharadwaj Ryan Luu Daisuke Kihara Daisuke Kihara LZerD Protein-Protein Docking Webserver Enhanced With de novo Structure Prediction Frontiers in Molecular Biosciences web server LZerD structure modeling protein bioinformatics protein-protein docking protein structure prediction |
author_facet |
Charles Christoffer Vijay Bharadwaj Ryan Luu Daisuke Kihara Daisuke Kihara |
author_sort |
Charles Christoffer |
title |
LZerD Protein-Protein Docking Webserver Enhanced With de novo Structure Prediction |
title_short |
LZerD Protein-Protein Docking Webserver Enhanced With de novo Structure Prediction |
title_full |
LZerD Protein-Protein Docking Webserver Enhanced With de novo Structure Prediction |
title_fullStr |
LZerD Protein-Protein Docking Webserver Enhanced With de novo Structure Prediction |
title_full_unstemmed |
LZerD Protein-Protein Docking Webserver Enhanced With de novo Structure Prediction |
title_sort |
lzerd protein-protein docking webserver enhanced with de novo structure prediction |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Molecular Biosciences |
issn |
2296-889X |
publishDate |
2021-08-01 |
description |
Protein-protein docking is a useful tool for modeling the structures of protein complexes that have yet to be experimentally determined. Understanding the structures of protein complexes is a key component for formulating hypotheses in biophysics regarding the functional mechanisms of complexes. Protein-protein docking is an established technique for cases where the structures of the subunits have been determined. While the number of known structures deposited in the Protein Data Bank is increasing, there are still many cases where the structures of individual proteins that users want to dock are not determined yet. Here, we have integrated the AttentiveDist method for protein structure prediction into our LZerD webserver for protein-protein docking, which enables users to simply submit protein sequences and obtain full-complex atomic models, without having to supply any structure themselves. We have further extended the LZerD docking interface with a symmetrical homodimer mode. The LZerD server is available at https://lzerd.kiharalab.org/. |
topic |
web server LZerD structure modeling protein bioinformatics protein-protein docking protein structure prediction |
url |
https://www.frontiersin.org/articles/10.3389/fmolb.2021.724947/full |
work_keys_str_mv |
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