SS18 regulates pluripotent-somatic transition through phase separation
Emerging evidence suggests that exit from pluripotency is a regulated, rather than passive process. Here the authors identify a requirement for SS18-mediated Brg/Brahma-associated factors (BAF) chromatin remodeling complex assembly during exit from pluripotency, and that SS18 promotes BAF assembly t...
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Format: | Article |
Language: | English |
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Nature Publishing Group
2021-07-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-24373-5 |
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doaj-bb43a8e0c9ca42d389c825e15445163f |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Junqi Kuang Ziwei Zhai Pengli Li Ruona Shi Wenjing Guo Yuxiang Yao Jing Guo Guoqing Zhao Jiangpin He Shuyang Xu Chuman Wu Shengyong Yu Chunhua Zhou Linlin Wu Yue Qin Baomei Cai Wei Li Zichao Wu Xiaoxi Li Shilong Chu Tingting Yang Bo Wang Shangtao Cao Dongwei Li Xiaofei Zhang Jiekai Chen Jing Liu Duanqing Pei |
spellingShingle |
Junqi Kuang Ziwei Zhai Pengli Li Ruona Shi Wenjing Guo Yuxiang Yao Jing Guo Guoqing Zhao Jiangpin He Shuyang Xu Chuman Wu Shengyong Yu Chunhua Zhou Linlin Wu Yue Qin Baomei Cai Wei Li Zichao Wu Xiaoxi Li Shilong Chu Tingting Yang Bo Wang Shangtao Cao Dongwei Li Xiaofei Zhang Jiekai Chen Jing Liu Duanqing Pei SS18 regulates pluripotent-somatic transition through phase separation Nature Communications |
author_facet |
Junqi Kuang Ziwei Zhai Pengli Li Ruona Shi Wenjing Guo Yuxiang Yao Jing Guo Guoqing Zhao Jiangpin He Shuyang Xu Chuman Wu Shengyong Yu Chunhua Zhou Linlin Wu Yue Qin Baomei Cai Wei Li Zichao Wu Xiaoxi Li Shilong Chu Tingting Yang Bo Wang Shangtao Cao Dongwei Li Xiaofei Zhang Jiekai Chen Jing Liu Duanqing Pei |
author_sort |
Junqi Kuang |
title |
SS18 regulates pluripotent-somatic transition through phase separation |
title_short |
SS18 regulates pluripotent-somatic transition through phase separation |
title_full |
SS18 regulates pluripotent-somatic transition through phase separation |
title_fullStr |
SS18 regulates pluripotent-somatic transition through phase separation |
title_full_unstemmed |
SS18 regulates pluripotent-somatic transition through phase separation |
title_sort |
ss18 regulates pluripotent-somatic transition through phase separation |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2021-07-01 |
description |
Emerging evidence suggests that exit from pluripotency is a regulated, rather than passive process. Here the authors identify a requirement for SS18-mediated Brg/Brahma-associated factors (BAF) chromatin remodeling complex assembly during exit from pluripotency, and that SS18 promotes BAF assembly through liquidliquid phase separation. |
url |
https://doi.org/10.1038/s41467-021-24373-5 |
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doaj-bb43a8e0c9ca42d389c825e15445163f2021-07-04T11:45:36ZengNature Publishing GroupNature Communications2041-17232021-07-0112111110.1038/s41467-021-24373-5SS18 regulates pluripotent-somatic transition through phase separationJunqi Kuang0Ziwei Zhai1Pengli Li2Ruona Shi3Wenjing Guo4Yuxiang Yao5Jing Guo6Guoqing Zhao7Jiangpin He8Shuyang Xu9Chuman Wu10Shengyong Yu11Chunhua Zhou12Linlin Wu13Yue Qin14Baomei Cai15Wei Li16Zichao Wu17Xiaoxi Li18Shilong Chu19Tingting Yang20Bo Wang21Shangtao Cao22Dongwei Li23Xiaofei Zhang24Jiekai Chen25Jing Liu26Duanqing Pei27CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesSchool of Physical Science and Technology, Lanzhou UniversityCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesGMU-GIBH Joint School of Life Sciences, Guangzhou Medical UniversityCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesSchool of Life Sciences, University of Science and Technology of ChinaCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesLaboratory of Cell Fate Control, School of Life Sciences, Westlake UniversityEmerging evidence suggests that exit from pluripotency is a regulated, rather than passive process. Here the authors identify a requirement for SS18-mediated Brg/Brahma-associated factors (BAF) chromatin remodeling complex assembly during exit from pluripotency, and that SS18 promotes BAF assembly through liquidliquid phase separation.https://doi.org/10.1038/s41467-021-24373-5 |