An fMRI Study of Neuronal Specificity in Acupuncture: The Multiacupoint Siguan and Its Sham Point
Clarifying the intrinsic mechanisms of acupuncture’s clinical effects has recently been gaining popularity. Here, we choose the Siguan acupoint (a combination of bilateral LI4 and Liv3) and its sham point to evaluate multiacupoint specificity. Thirty-one healthy volunteers were randomly divided into...
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Online Access: | http://dx.doi.org/10.1155/2014/103491 |
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doaj-bb506c6f3a9843278ad13959278161252020-11-24T23:48:40ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882014-01-01201410.1155/2014/103491103491An fMRI Study of Neuronal Specificity in Acupuncture: The Multiacupoint Siguan and Its Sham PointYi Shan0Zhi-qun Wang1Zhi-lian Zhao2Mo Zhang3Shi-lei Hao4Jian-yang Xu5Bao-ci Shan6Jie Lu7Kun-cheng Li8Department of Radiology, Xuanwu Hospital of Capital Medical University, 45 Changchunjie, Xicheng District, Beijing 100053, ChinaDepartment of Radiology, Xuanwu Hospital of Capital Medical University, 45 Changchunjie, Xicheng District, Beijing 100053, ChinaDepartment of Radiology, Xuanwu Hospital of Capital Medical University, 45 Changchunjie, Xicheng District, Beijing 100053, ChinaDepartment of Radiology, Xuanwu Hospital of Capital Medical University, 45 Changchunjie, Xicheng District, Beijing 100053, ChinaGeneral Hospital of Chinese People’s Armed Police Forces, Beijing 100053, ChinaGeneral Hospital of Chinese People’s Armed Police Forces, Beijing 100053, ChinaInstitute of High Energy Physics, Chinese Academy of Sciences, Beijing 100053, ChinaDepartment of Radiology, Xuanwu Hospital of Capital Medical University, 45 Changchunjie, Xicheng District, Beijing 100053, ChinaDepartment of Radiology, Xuanwu Hospital of Capital Medical University, 45 Changchunjie, Xicheng District, Beijing 100053, ChinaClarifying the intrinsic mechanisms of acupuncture’s clinical effects has recently been gaining popularity. Here, we choose the Siguan acupoint (a combination of bilateral LI4 and Liv3) and its sham point to evaluate multiacupoint specificity. Thirty-one healthy volunteers were randomly divided into real acupoint (21 subjects) and sham acupoint (10 subjects) groups. Our study used a single block experimental design to avoid the influence of posteffects. Functional magnetic resonance imaging data were acquired during acupuncture stimulation. Results showed extensive increase in neuronal activities with Siguan acupuncture and significant differences between stimulation at real and sham points. Brain regions that were activated more by real acupuncture stimulation than by sham point acupuncture included somatosensory cortex (the superior parietal lobule and postcentral gyrus), limbic-paralimbic system (the calcarine gyrus, precuneus, cingulate cortex, and parahippocampal gyrus), visual-related cortex (the fusiform and occipital gyri), basal ganglia, and the cerebellum. In this way, our study suggests Siguan may elicit specific activities in human brain.http://dx.doi.org/10.1155/2014/103491 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yi Shan Zhi-qun Wang Zhi-lian Zhao Mo Zhang Shi-lei Hao Jian-yang Xu Bao-ci Shan Jie Lu Kun-cheng Li |
spellingShingle |
Yi Shan Zhi-qun Wang Zhi-lian Zhao Mo Zhang Shi-lei Hao Jian-yang Xu Bao-ci Shan Jie Lu Kun-cheng Li An fMRI Study of Neuronal Specificity in Acupuncture: The Multiacupoint Siguan and Its Sham Point Evidence-Based Complementary and Alternative Medicine |
author_facet |
Yi Shan Zhi-qun Wang Zhi-lian Zhao Mo Zhang Shi-lei Hao Jian-yang Xu Bao-ci Shan Jie Lu Kun-cheng Li |
author_sort |
Yi Shan |
title |
An fMRI Study of Neuronal Specificity in Acupuncture: The Multiacupoint Siguan and Its Sham Point |
title_short |
An fMRI Study of Neuronal Specificity in Acupuncture: The Multiacupoint Siguan and Its Sham Point |
title_full |
An fMRI Study of Neuronal Specificity in Acupuncture: The Multiacupoint Siguan and Its Sham Point |
title_fullStr |
An fMRI Study of Neuronal Specificity in Acupuncture: The Multiacupoint Siguan and Its Sham Point |
title_full_unstemmed |
An fMRI Study of Neuronal Specificity in Acupuncture: The Multiacupoint Siguan and Its Sham Point |
title_sort |
fmri study of neuronal specificity in acupuncture: the multiacupoint siguan and its sham point |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2014-01-01 |
description |
Clarifying the intrinsic mechanisms of acupuncture’s clinical effects has recently been gaining popularity. Here, we choose the Siguan acupoint (a combination of bilateral LI4 and Liv3) and its sham point to evaluate multiacupoint specificity. Thirty-one healthy volunteers were randomly divided into real acupoint (21 subjects) and sham acupoint (10 subjects) groups. Our study used a single block experimental design to avoid the influence of posteffects. Functional magnetic resonance imaging data were acquired during acupuncture stimulation. Results showed extensive increase in neuronal activities with Siguan acupuncture and significant differences between stimulation at real and sham points. Brain regions that were activated more by real acupuncture stimulation than by sham point acupuncture included somatosensory cortex (the superior parietal lobule and postcentral gyrus), limbic-paralimbic system (the calcarine gyrus, precuneus, cingulate cortex, and parahippocampal gyrus), visual-related cortex (the fusiform and occipital gyri), basal ganglia, and the cerebellum. In this way, our study suggests Siguan may elicit specific activities in human brain. |
url |
http://dx.doi.org/10.1155/2014/103491 |
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