The Inflammasome in Reproductive Biology: A Promising Target for Novel Therapies

The inflammasome is a key regulator of innate immunity involved in the inflammatory response to infections as well as disease through the activation of caspase-1 and the processing of the inflammatory cytokines interleukin (IL)-1β and IL-18. Even though the inflammasome was first described in the co...

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Main Author: Juan Pablo de Rivero Vaccari
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Endocrinology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00008/full
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spelling doaj-bb53224ad4204023967b75408eba3e832020-11-24T22:07:33ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-01-011110.3389/fendo.2020.00008496226The Inflammasome in Reproductive Biology: A Promising Target for Novel TherapiesJuan Pablo de Rivero Vaccari0Juan Pablo de Rivero Vaccari1Juan Pablo de Rivero Vaccari2Department of Neurological Surgery and The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, United StatesCenter for Cognitive Neuroscience and Aging, University of Miami Miller School of Medicine, Miami, FL, United StatesInflamaCORE, LLC, Miami, FL, United StatesThe inflammasome is a key regulator of innate immunity involved in the inflammatory response to infections as well as disease through the activation of caspase-1 and the processing of the inflammatory cytokines interleukin (IL)-1β and IL-18. Even though the inflammasome was first described in the context of infections, most research in recent years has focused on targeting the inflammasome as a therapeutic option in sterile inflammatory events. Recent evidence indicates a clear involvement of the inflammasome in Reproductive Biology such as infertility and preeclampsia. In this mini-review, I summarize the current findings on the inflammasome that have been described in the field of Reproductive Biology and highlight the potential that the inflammasome has as a novel therapeutic option in this field. The topics covered in this review as it pertains to the inflammasome field cover the literature published on male and female infertility, endometriosis, preeclampsia, placental inflammation, and reproductive senescence.https://www.frontiersin.org/article/10.3389/fendo.2020.00008/fullinflammasomefertilityinflammationcaspase-1reproduction
collection DOAJ
language English
format Article
sources DOAJ
author Juan Pablo de Rivero Vaccari
Juan Pablo de Rivero Vaccari
Juan Pablo de Rivero Vaccari
spellingShingle Juan Pablo de Rivero Vaccari
Juan Pablo de Rivero Vaccari
Juan Pablo de Rivero Vaccari
The Inflammasome in Reproductive Biology: A Promising Target for Novel Therapies
Frontiers in Endocrinology
inflammasome
fertility
inflammation
caspase-1
reproduction
author_facet Juan Pablo de Rivero Vaccari
Juan Pablo de Rivero Vaccari
Juan Pablo de Rivero Vaccari
author_sort Juan Pablo de Rivero Vaccari
title The Inflammasome in Reproductive Biology: A Promising Target for Novel Therapies
title_short The Inflammasome in Reproductive Biology: A Promising Target for Novel Therapies
title_full The Inflammasome in Reproductive Biology: A Promising Target for Novel Therapies
title_fullStr The Inflammasome in Reproductive Biology: A Promising Target for Novel Therapies
title_full_unstemmed The Inflammasome in Reproductive Biology: A Promising Target for Novel Therapies
title_sort inflammasome in reproductive biology: a promising target for novel therapies
publisher Frontiers Media S.A.
series Frontiers in Endocrinology
issn 1664-2392
publishDate 2020-01-01
description The inflammasome is a key regulator of innate immunity involved in the inflammatory response to infections as well as disease through the activation of caspase-1 and the processing of the inflammatory cytokines interleukin (IL)-1β and IL-18. Even though the inflammasome was first described in the context of infections, most research in recent years has focused on targeting the inflammasome as a therapeutic option in sterile inflammatory events. Recent evidence indicates a clear involvement of the inflammasome in Reproductive Biology such as infertility and preeclampsia. In this mini-review, I summarize the current findings on the inflammasome that have been described in the field of Reproductive Biology and highlight the potential that the inflammasome has as a novel therapeutic option in this field. The topics covered in this review as it pertains to the inflammasome field cover the literature published on male and female infertility, endometriosis, preeclampsia, placental inflammation, and reproductive senescence.
topic inflammasome
fertility
inflammation
caspase-1
reproduction
url https://www.frontiersin.org/article/10.3389/fendo.2020.00008/full
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