Stepwise Induction of Inner Ear Hair Cells From Mouse Embryonic Fibroblasts via Mesenchymal- to-Epithelial Transition and Formation of Otic Epithelial Cells

Stepwise Induction of Inner Ear Hair Cells From Mouse Embryonic Fibroblasts via Mesenchymal- to-Epithelial Transition and Formation of Otic Epithelial Cells

Although embryonic stem cells or induced pluripotent stem cells are able to differentiate into inner ear hair cells (HCs), they have drawbacks limiting their clinical application, including a potential risk of tumourigenicity. Direct reprogramming of fibroblasts to inner ear HCs could offer an alter...

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Bibliographic Details
Main Authors: Qiong Yang, Haosong Shi, Yizhou Quan, Qianqian Chen, Wang Li, Li Wang, Yonghui Wang, Zhongzhong Ji, Shan-Kai Yin, Hai-Bo Shi, Huiming Xu, Wei-Qiang Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
hair cell regeneration
mesenchymal-to-epithelial transition (MET)
hearing loss
mouse embryonic fibroblasts
transdifferentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.672406/full

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