Challenging Received Wisdom: Antidepressants and the Placebo Effect

This article explores the reaction when an article challenging received wisdom is published and covered extensively by the media (1). The article in question was a meta-analysis of antidepressant clinical trials indicating that for most patients, difference between drug and placebo was not clinicall...

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Main Author: Irving Kirsch
Format: Article
Language:English
Published: McGill University 2020-12-01
Series:McGill Journal of Medicine
Subjects:
Online Access:https://mjm.mcgill.ca/article/view/571
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spelling doaj-bb5c7a8f52ea4828b9214947989857832021-01-22T03:36:11ZengMcGill UniversityMcGill Journal of Medicine1715-81252020-12-0111210.26443/mjm.v11i2.571786Challenging Received Wisdom: Antidepressants and the Placebo EffectIrving KirschThis article explores the reaction when an article challenging received wisdom is published and covered extensively by the media (1). The article in question was a meta-analysis of antidepressant clinical trials indicating that for most patients, difference between drug and placebo was not clinically significant. Reactions ranged from denial that the effects of antidepressants are so small to criticisms of the clinical trials that were analyzed. Each of these reactions is explored and countered.https://mjm.mcgill.ca/article/view/571antidepressantsplacebo
collection DOAJ
language English
format Article
sources DOAJ
author Irving Kirsch
spellingShingle Irving Kirsch
Challenging Received Wisdom: Antidepressants and the Placebo Effect
McGill Journal of Medicine
antidepressants
placebo
author_facet Irving Kirsch
author_sort Irving Kirsch
title Challenging Received Wisdom: Antidepressants and the Placebo Effect
title_short Challenging Received Wisdom: Antidepressants and the Placebo Effect
title_full Challenging Received Wisdom: Antidepressants and the Placebo Effect
title_fullStr Challenging Received Wisdom: Antidepressants and the Placebo Effect
title_full_unstemmed Challenging Received Wisdom: Antidepressants and the Placebo Effect
title_sort challenging received wisdom: antidepressants and the placebo effect
publisher McGill University
series McGill Journal of Medicine
issn 1715-8125
publishDate 2020-12-01
description This article explores the reaction when an article challenging received wisdom is published and covered extensively by the media (1). The article in question was a meta-analysis of antidepressant clinical trials indicating that for most patients, difference between drug and placebo was not clinically significant. Reactions ranged from denial that the effects of antidepressants are so small to criticisms of the clinical trials that were analyzed. Each of these reactions is explored and countered.
topic antidepressants
placebo
url https://mjm.mcgill.ca/article/view/571
work_keys_str_mv AT irvingkirsch challengingreceivedwisdomantidepressantsandtheplaceboeffect
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