Wasting Away with Cirrhosis: A Review of Hepatic Sarcopenia

Wasting Away with Cirrhosis: A Review of Hepatic Sarcopenia

The complications of decompensated cirrhosis are well documented and include variceal bleeding, fluid retention, and hepatic encephalopathy. A less well recognized complication of cirrhosis is muscle wasting or sarcopenia. It is now recognized to have a significant impact on patient survival, espec...

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Bibliographic Details
Main Authors: Jan Freeman, Andrew Austin, Ernesto Robalino Gonzaga
Format: Article
Language:English
Published: Codon Publications 2019-09-01
Series:Journal of Renal and Hepatic Disorders
Subjects:
sarcopenia
cirrhosis
wasting
end-stage liver disease
muscle
Online Access:https://jrenhep.com/index.php/jrenhep/article/view/56
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spelling doaj-bb7044e4471044f68cc853dc4d77e3fd2020-11-25T03:25:20ZengCodon PublicationsJournal of Renal and Hepatic Disorders2207-37442019-09-013110.15586/jrenhep.2019.56Wasting Away with Cirrhosis: A Review of Hepatic SarcopeniaJan Freeman0Andrew Austin1Ernesto Robalino Gonzaga2Hepatology Unit, University Hospitals of Derby and Burton on Trent, Derby, UKHepatology Unit, University Hospitals of Derby and Burton on Trent, Derby, UKDepartment of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL, USA The complications of decompensated cirrhosis are well documented and include variceal bleeding, fluid retention, and hepatic encephalopathy. A less well recognized complication of cirrhosis is muscle wasting or sarcopenia. It is now recognized to have a significant impact on patient survival, especially in patients who are awaiting liver transplantation. An understanding of the pathophysiology of muscle protein homeostasis has led to several proposed mechanisms of sarcopenia and the potential to reverse muscle loss. This review discusses the potential mechanisms of sarcopenia and highlights the possible future means of reversing sarcopenia. https://jrenhep.com/index.php/jrenhep/article/view/56sarcopeniacirrhosiswastingend-stage liver diseasemuscle
collection DOAJ
language English
format Article
sources DOAJ
author Jan Freeman
Andrew Austin
Ernesto Robalino Gonzaga
spellingShingle Jan Freeman
Andrew Austin
Ernesto Robalino Gonzaga
Wasting Away with Cirrhosis: A Review of Hepatic Sarcopenia
Journal of Renal and Hepatic Disorders
sarcopenia
cirrhosis
wasting
end-stage liver disease
muscle
author_facet Jan Freeman
Andrew Austin
Ernesto Robalino Gonzaga
author_sort Jan Freeman
title Wasting Away with Cirrhosis: A Review of Hepatic Sarcopenia
title_short Wasting Away with Cirrhosis: A Review of Hepatic Sarcopenia
title_full Wasting Away with Cirrhosis: A Review of Hepatic Sarcopenia
title_fullStr Wasting Away with Cirrhosis: A Review of Hepatic Sarcopenia
title_full_unstemmed Wasting Away with Cirrhosis: A Review of Hepatic Sarcopenia
title_sort wasting away with cirrhosis: a review of hepatic sarcopenia
publisher Codon Publications
series Journal of Renal and Hepatic Disorders
issn 2207-3744
publishDate 2019-09-01
description The complications of decompensated cirrhosis are well documented and include variceal bleeding, fluid retention, and hepatic encephalopathy. A less well recognized complication of cirrhosis is muscle wasting or sarcopenia. It is now recognized to have a significant impact on patient survival, especially in patients who are awaiting liver transplantation. An understanding of the pathophysiology of muscle protein homeostasis has led to several proposed mechanisms of sarcopenia and the potential to reverse muscle loss. This review discusses the potential mechanisms of sarcopenia and highlights the possible future means of reversing sarcopenia.
topic sarcopenia
cirrhosis
wasting
end-stage liver disease
muscle
url https://jrenhep.com/index.php/jrenhep/article/view/56
work_keys_str_mv AT janfreeman wastingawaywithcirrhosisareviewofhepaticsarcopenia
AT andrewaustin wastingawaywithcirrhosisareviewofhepaticsarcopenia
AT ernestorobalinogonzaga wastingawaywithcirrhosisareviewofhepaticsarcopenia
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