A synthetic biochemistry platform for cell free production of monoterpenes from glucose

A synthetic biochemistry platform for cell free production of monoterpenes from glucose

Terpenes are bioactive natural products derived from plants with several commercial applications. Here, the authors engineer a cell-free system composed of 27 enzymes that convert glucose into terpenes, highlighting the potential of synthetic biochemistry approaches for biocompounds production.

Bibliographic Details
Main Authors: Tyler P. Korman, Paul H. Opgenorth, James U. Bowie
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15526
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spelling doaj-bb8ace10bdcb41a5a7a1b989f4dffc782021-05-11T07:38:35ZengNature Publishing GroupNature Communications2041-17232017-05-01811810.1038/ncomms15526A synthetic biochemistry platform for cell free production of monoterpenes from glucoseTyler P. Korman0Paul H. Opgenorth1James U. Bowie2Department of Chemistry and Biochemistry, UCLA-DOE Institute, Molecular Biology Institute, University of CaliforniaDepartment of Chemistry and Biochemistry, UCLA-DOE Institute, Molecular Biology Institute, University of CaliforniaDepartment of Chemistry and Biochemistry, UCLA-DOE Institute, Molecular Biology Institute, University of CaliforniaTerpenes are bioactive natural products derived from plants with several commercial applications. Here, the authors engineer a cell-free system composed of 27 enzymes that convert glucose into terpenes, highlighting the potential of synthetic biochemistry approaches for biocompounds production.https://doi.org/10.1038/ncomms15526
collection DOAJ
language English
format Article
sources DOAJ
author Tyler P. Korman
Paul H. Opgenorth
James U. Bowie
spellingShingle Tyler P. Korman
Paul H. Opgenorth
James U. Bowie
A synthetic biochemistry platform for cell free production of monoterpenes from glucose
Nature Communications
author_facet Tyler P. Korman
Paul H. Opgenorth
James U. Bowie
author_sort Tyler P. Korman
title A synthetic biochemistry platform for cell free production of monoterpenes from glucose
title_short A synthetic biochemistry platform for cell free production of monoterpenes from glucose
title_full A synthetic biochemistry platform for cell free production of monoterpenes from glucose
title_fullStr A synthetic biochemistry platform for cell free production of monoterpenes from glucose
title_full_unstemmed A synthetic biochemistry platform for cell free production of monoterpenes from glucose
title_sort synthetic biochemistry platform for cell free production of monoterpenes from glucose
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-05-01
description Terpenes are bioactive natural products derived from plants with several commercial applications. Here, the authors engineer a cell-free system composed of 27 enzymes that convert glucose into terpenes, highlighting the potential of synthetic biochemistry approaches for biocompounds production.
url https://doi.org/10.1038/ncomms15526
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AT paulhopgenorth asyntheticbiochemistryplatformforcellfreeproductionofmonoterpenesfromglucose
AT jamesubowie asyntheticbiochemistryplatformforcellfreeproductionofmonoterpenesfromglucose
AT tylerpkorman syntheticbiochemistryplatformforcellfreeproductionofmonoterpenesfromglucose
AT paulhopgenorth syntheticbiochemistryplatformforcellfreeproductionofmonoterpenesfromglucose
AT jamesubowie syntheticbiochemistryplatformforcellfreeproductionofmonoterpenesfromglucose
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