Role of genetic factors on the effect of additional loading doses and two maintenance doses used to overcome clopidogrel hyporesponsiveness

Role of genetic factors on the effect of additional loading doses and two maintenance doses used to overcome clopidogrel hyporesponsiveness

Background and objective: Additional loading doses and higher maintenance doses (MDs) have been used to overcome hyporesponsiveness of clopidogrel. We aimed to investigate whether genetic polymorphisms of two cytochromes (CYP2C19 and CYP2C9) and ABCB1 modify effect of such dose-adjustment strategy....

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Bibliographic Details
Main Authors: Gustavs Latkovskis, Inga Urtane, Agnese Knipse, Raitis Peculis, Inese Cakstina, Janis Klovins, Andrejs Erglis
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:Medicina
Subjects:
Clopidogrel resistance
VASP
CYP2C19
ABCB1
CYP2C9
Online Access:http://www.sciencedirect.com/science/article/pii/S1010660X14000056

Internet

http://www.sciencedirect.com/science/article/pii/S1010660X14000056

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