A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles

A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles

In this paper, highly purified and stable gold nanoparticle (AuNP) dimers connected at the two ends of DNA linkage were prepared by a versatile method. A nanostructured, surface-enhanced Raman scattering (SERS) switching sensor system was fabricated based on the controlled organization of gold nanop...

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Bibliographic Details
Main Authors: Yansheng Li, Yaya Cheng, Liping Xu, Hongwu Du, Peixun Zhang, Yongqiang Wen, Xueji Zhang
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:Nanomaterials
Subjects:
molecular beacon sensors
switch
self-assembly
surface-enhanced Raman scattering (SERS)
gold nanoparticles
Online Access:http://www.mdpi.com/2079-4991/6/2/24
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spelling doaj-bb9620519ed04adf9fee2af4cc38cbc72020-11-25T00:12:09ZengMDPI AGNanomaterials2079-49912016-01-01622410.3390/nano6020024nano6020024A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold NanoparticlesYansheng Li0Yaya Cheng1Liping Xu2Hongwu Du3Peixun Zhang4Yongqiang Wen5Xueji Zhang6Department of Chemistry and Biological Engineering, University of Science and Technology, Beijing 100083, ChinaDepartment of Chemistry and Biological Engineering, University of Science and Technology, Beijing 100083, ChinaDepartment of Chemistry and Biological Engineering, University of Science and Technology, Beijing 100083, ChinaDepartment of Chemistry and Biological Engineering, University of Science and Technology, Beijing 100083, ChinaPeking University People’s Hospital, Beijing 100083, ChinaDepartment of Chemistry and Biological Engineering, University of Science and Technology, Beijing 100083, ChinaDepartment of Chemistry and Biological Engineering, University of Science and Technology, Beijing 100083, ChinaIn this paper, highly purified and stable gold nanoparticle (AuNP) dimers connected at the two ends of DNA linkage were prepared by a versatile method. A nanostructured, surface-enhanced Raman scattering (SERS) switching sensor system was fabricated based on the controlled organization of gold nanoparticles (AuNPs) by a DNA nanomachine through the controlled formation/deformation of SERS “hotspots”. This strategy not only opens opportunities in the precise engineering of gap distances in gold-gold nanostructures in a highly controllable and reproducible fashion, but also provides a unique ability to research the origin of SERS and sequence-specific DNA detection.http://www.mdpi.com/2079-4991/6/2/24molecular beacon sensorsswitchself-assemblysurface-enhanced Raman scattering (SERS)gold nanoparticles
collection DOAJ
language English
format Article
sources DOAJ
author Yansheng Li
Yaya Cheng
Liping Xu
Hongwu Du
Peixun Zhang
Yongqiang Wen
Xueji Zhang
spellingShingle Yansheng Li
Yaya Cheng
Liping Xu
Hongwu Du
Peixun Zhang
Yongqiang Wen
Xueji Zhang
A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles
Nanomaterials
molecular beacon sensors
switch
self-assembly
surface-enhanced Raman scattering (SERS)
gold nanoparticles
author_facet Yansheng Li
Yaya Cheng
Liping Xu
Hongwu Du
Peixun Zhang
Yongqiang Wen
Xueji Zhang
author_sort Yansheng Li
title A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles
title_short A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles
title_full A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles
title_fullStr A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles
title_full_unstemmed A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles
title_sort nanostructured sers switch based on molecular beacon-controlled assembly of gold nanoparticles
publisher MDPI AG
series Nanomaterials
issn 2079-4991
publishDate 2016-01-01
description In this paper, highly purified and stable gold nanoparticle (AuNP) dimers connected at the two ends of DNA linkage were prepared by a versatile method. A nanostructured, surface-enhanced Raman scattering (SERS) switching sensor system was fabricated based on the controlled organization of gold nanoparticles (AuNPs) by a DNA nanomachine through the controlled formation/deformation of SERS “hotspots”. This strategy not only opens opportunities in the precise engineering of gap distances in gold-gold nanostructures in a highly controllable and reproducible fashion, but also provides a unique ability to research the origin of SERS and sequence-specific DNA detection.
topic molecular beacon sensors
switch
self-assembly
surface-enhanced Raman scattering (SERS)
gold nanoparticles
url http://www.mdpi.com/2079-4991/6/2/24
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