Deaths Attributable to Carbapenem-Resistant Enterobacteriaceae Infections
We evaluated the number of deaths attributable to carbapenem-resistant Enterobacteriaceae by using studies from around the world published before April 9, 2012. Attributable death was defined as the difference in all-cause deaths between patients with carbapenem-resistant infections and those with c...
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Centers for Disease Control and Prevention
2014-07-01
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doaj-bb9d45c9d1224a1a94be08d17364ad652020-11-24T21:45:43ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592014-07-012071170117510.3201/eid2007.121004Deaths Attributable to Carbapenem-Resistant Enterobacteriaceae InfectionsMatthew E. FalagasGiannoula S. TansarliDrosos E. KarageorgopoulosKonstantinos Z. VardakasWe evaluated the number of deaths attributable to carbapenem-resistant Enterobacteriaceae by using studies from around the world published before April 9, 2012. Attributable death was defined as the difference in all-cause deaths between patients with carbapenem-resistant infections and those with carbapenem-susceptible infections. Online databases were searched, and data were qualitatively synthesized and pooled in a metaanalysis. Nine studies met inclusion criteria: 6 retrospective case–control studies, 2 retrospective cohort studies, and 1 prospective cohort study. Klebsiella pneumoniae was the causative pathogen in 8 studies; bacteremia was the only infection in 5 studies. We calculated that 26%–44% of deaths in 7 studies were attributable to carbapenem resistance, and in 2 studies, which included bacteremia and other infections, −3% and −4% of deaths were attributable to carbapenem resistance. Pooled outcomes showed that the number of deaths was significantly higher in patients with carbapenem-resistant infections and that the number of deaths attributable to carbapenem resistance is considerable.https://wwwnc.cdc.gov/eid/article/20/7/12-1004_articlecarbapenem resistancebloodstream infectionEnterobacteriaceaecarbapenem-resistant EnterobacteriaceaeinfectionsKlebsiella pneumoniae |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Matthew E. Falagas Giannoula S. Tansarli Drosos E. Karageorgopoulos Konstantinos Z. Vardakas |
spellingShingle |
Matthew E. Falagas Giannoula S. Tansarli Drosos E. Karageorgopoulos Konstantinos Z. Vardakas Deaths Attributable to Carbapenem-Resistant Enterobacteriaceae Infections Emerging Infectious Diseases carbapenem resistance bloodstream infection Enterobacteriaceae carbapenem-resistant Enterobacteriaceae infections Klebsiella pneumoniae |
author_facet |
Matthew E. Falagas Giannoula S. Tansarli Drosos E. Karageorgopoulos Konstantinos Z. Vardakas |
author_sort |
Matthew E. Falagas |
title |
Deaths Attributable to Carbapenem-Resistant Enterobacteriaceae Infections |
title_short |
Deaths Attributable to Carbapenem-Resistant Enterobacteriaceae Infections |
title_full |
Deaths Attributable to Carbapenem-Resistant Enterobacteriaceae Infections |
title_fullStr |
Deaths Attributable to Carbapenem-Resistant Enterobacteriaceae Infections |
title_full_unstemmed |
Deaths Attributable to Carbapenem-Resistant Enterobacteriaceae Infections |
title_sort |
deaths attributable to carbapenem-resistant enterobacteriaceae infections |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2014-07-01 |
description |
We evaluated the number of deaths attributable to carbapenem-resistant Enterobacteriaceae by using studies from around the world published before April 9, 2012. Attributable death was defined as the difference in all-cause deaths between patients with carbapenem-resistant infections and those with carbapenem-susceptible infections. Online databases were searched, and data were qualitatively synthesized and pooled in a metaanalysis. Nine studies met inclusion criteria: 6 retrospective case–control studies, 2 retrospective cohort studies, and 1 prospective cohort study. Klebsiella pneumoniae was the causative pathogen in 8 studies; bacteremia was the only infection in 5 studies. We calculated that 26%–44% of deaths in 7 studies were attributable to carbapenem resistance, and in 2 studies, which included bacteremia and other infections, −3% and −4% of deaths were attributable to carbapenem resistance. Pooled outcomes showed that the number of deaths was significantly higher in patients with carbapenem-resistant infections and that the number of deaths attributable to carbapenem resistance is considerable. |
topic |
carbapenem resistance bloodstream infection Enterobacteriaceae carbapenem-resistant Enterobacteriaceae infections Klebsiella pneumoniae |
url |
https://wwwnc.cdc.gov/eid/article/20/7/12-1004_article |
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