CYTPOWER: IMPLEMENTATION OF CYTOTOXIC POWER CONCEPT IN PYTHON

• Main Authors: Maksim Aleksandrovich Terpilovskii, Dr., Nikolay Vasilievich Goncharov, Dr.
• Format: Article
• Language: English
• Published: Cifra Publishing House 2018-11-01
• Series: Journal of Bioinformatics and Genomics
• Online Access: http://journal-biogen.org/article/view/105

Currently existing methods and parameters are inadequate for representative and quanititative assessment of cytotoxic activity of chemical compounds. Recently, we have introduced a concept of cytotoxic power which provides an effective way to a reasonable estimation and comparative analysis of cytotoxic activity of chemical agents. The basis of this concept is an integrative parameter that relies on important toxicological principles: dose of compound related to a cell number and exposure-time-response relationship of its activity. Herein, we propose a proof-of-concept implementation of our concept of cytotoxic power as a package developed in Python programming language. The package is free and available on GitHub repository.