A new insight into the role of aryl hydrocarbon receptor (AhR) in the migration of glioblastoma by AhR-IL24 axis regulation
Cancer occurrence and development are closely related to the environment. Aryl hydrocarbon receptor (AhR) is an important receptor mediating the toxic effects of many environmental compounds, and is also involved in regulating tumor cell migration. Glioblastoma is the most malignant glioma and exhib...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-09-01
|
Series: | Environment International |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S016041202100283X |
id |
doaj-bbadc115a4484ddc9f6bca5bfd74d007 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yiyun Liu Yangsheng Chen Rui Sha Yunping Li Tong Xu Xiaoxu Hu Li Xu Qunhui Xie Bin Zhao |
spellingShingle |
Yiyun Liu Yangsheng Chen Rui Sha Yunping Li Tong Xu Xiaoxu Hu Li Xu Qunhui Xie Bin Zhao A new insight into the role of aryl hydrocarbon receptor (AhR) in the migration of glioblastoma by AhR-IL24 axis regulation Environment International Glioblastoma Aryl hydrocarbon receptor Interleukin 24 Migration |
author_facet |
Yiyun Liu Yangsheng Chen Rui Sha Yunping Li Tong Xu Xiaoxu Hu Li Xu Qunhui Xie Bin Zhao |
author_sort |
Yiyun Liu |
title |
A new insight into the role of aryl hydrocarbon receptor (AhR) in the migration of glioblastoma by AhR-IL24 axis regulation |
title_short |
A new insight into the role of aryl hydrocarbon receptor (AhR) in the migration of glioblastoma by AhR-IL24 axis regulation |
title_full |
A new insight into the role of aryl hydrocarbon receptor (AhR) in the migration of glioblastoma by AhR-IL24 axis regulation |
title_fullStr |
A new insight into the role of aryl hydrocarbon receptor (AhR) in the migration of glioblastoma by AhR-IL24 axis regulation |
title_full_unstemmed |
A new insight into the role of aryl hydrocarbon receptor (AhR) in the migration of glioblastoma by AhR-IL24 axis regulation |
title_sort |
new insight into the role of aryl hydrocarbon receptor (ahr) in the migration of glioblastoma by ahr-il24 axis regulation |
publisher |
Elsevier |
series |
Environment International |
issn |
0160-4120 |
publishDate |
2021-09-01 |
description |
Cancer occurrence and development are closely related to the environment. Aryl hydrocarbon receptor (AhR) is an important receptor mediating the toxic effects of many environmental compounds, and is also involved in regulating tumor cell migration. Glioblastoma is the most malignant glioma and exhibits high motility, but the effects of AhR on the migration of glioblastoma are still unclear. We aimed to understand the role of AhR in the migration of this type of tumor cell and to explore the underlying molecular mechanism. In cultured human neuroblastoma cells (U87), we found that AhR overexpression or knockdown increased or suppressed the migration ability of U87 cells, respectively. Furthermore, inhibition of basal activation of the AhR pathway suppressed migration ability, suggesting a positive correlation between endogenous activity of the AhR pathway and cell migration. When the AhR pathway was activated by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 6-formyl [3,2-b] carbazole (FICZ), the migration of U87 cells was inhibited by inducing the expression of a tumor suppressor, IL24, which is a downstream responsive gene of AhR activation. Moreover, a similar AhR-IL24-dependent mechanism for migration inhibition of TCDD was documented in a breast cancer cell line and a lung cancer cell line. This study demonstrated that AhR plays important roles in regulating the migration of glioblastoma, and the induction of the AhR-IL24 axis mediates the inhibition of migration in response to TCDD or FICZ treatment. |
topic |
Glioblastoma Aryl hydrocarbon receptor Interleukin 24 Migration |
url |
http://www.sciencedirect.com/science/article/pii/S016041202100283X |
work_keys_str_mv |
AT yiyunliu anewinsightintotheroleofarylhydrocarbonreceptorahrinthemigrationofglioblastomabyahril24axisregulation AT yangshengchen anewinsightintotheroleofarylhydrocarbonreceptorahrinthemigrationofglioblastomabyahril24axisregulation AT ruisha anewinsightintotheroleofarylhydrocarbonreceptorahrinthemigrationofglioblastomabyahril24axisregulation AT yunpingli anewinsightintotheroleofarylhydrocarbonreceptorahrinthemigrationofglioblastomabyahril24axisregulation AT tongxu anewinsightintotheroleofarylhydrocarbonreceptorahrinthemigrationofglioblastomabyahril24axisregulation AT xiaoxuhu anewinsightintotheroleofarylhydrocarbonreceptorahrinthemigrationofglioblastomabyahril24axisregulation AT lixu anewinsightintotheroleofarylhydrocarbonreceptorahrinthemigrationofglioblastomabyahril24axisregulation AT qunhuixie anewinsightintotheroleofarylhydrocarbonreceptorahrinthemigrationofglioblastomabyahril24axisregulation AT binzhao anewinsightintotheroleofarylhydrocarbonreceptorahrinthemigrationofglioblastomabyahril24axisregulation AT yiyunliu newinsightintotheroleofarylhydrocarbonreceptorahrinthemigrationofglioblastomabyahril24axisregulation AT yangshengchen newinsightintotheroleofarylhydrocarbonreceptorahrinthemigrationofglioblastomabyahril24axisregulation AT ruisha newinsightintotheroleofarylhydrocarbonreceptorahrinthemigrationofglioblastomabyahril24axisregulation AT yunpingli newinsightintotheroleofarylhydrocarbonreceptorahrinthemigrationofglioblastomabyahril24axisregulation AT tongxu newinsightintotheroleofarylhydrocarbonreceptorahrinthemigrationofglioblastomabyahril24axisregulation AT xiaoxuhu newinsightintotheroleofarylhydrocarbonreceptorahrinthemigrationofglioblastomabyahril24axisregulation AT lixu newinsightintotheroleofarylhydrocarbonreceptorahrinthemigrationofglioblastomabyahril24axisregulation AT qunhuixie newinsightintotheroleofarylhydrocarbonreceptorahrinthemigrationofglioblastomabyahril24axisregulation AT binzhao newinsightintotheroleofarylhydrocarbonreceptorahrinthemigrationofglioblastomabyahril24axisregulation |
_version_ |
1721377606583975936 |
spelling |
doaj-bbadc115a4484ddc9f6bca5bfd74d0072021-06-15T04:13:31ZengElsevierEnvironment International0160-41202021-09-01154106658A new insight into the role of aryl hydrocarbon receptor (AhR) in the migration of glioblastoma by AhR-IL24 axis regulationYiyun Liu0Yangsheng Chen1Rui Sha2Yunping Li3Tong Xu4Xiaoxu Hu5Li Xu6Qunhui Xie7Bin Zhao8State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China; Corresponding authors at: Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China; Corresponding authors at: Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.Cancer occurrence and development are closely related to the environment. Aryl hydrocarbon receptor (AhR) is an important receptor mediating the toxic effects of many environmental compounds, and is also involved in regulating tumor cell migration. Glioblastoma is the most malignant glioma and exhibits high motility, but the effects of AhR on the migration of glioblastoma are still unclear. We aimed to understand the role of AhR in the migration of this type of tumor cell and to explore the underlying molecular mechanism. In cultured human neuroblastoma cells (U87), we found that AhR overexpression or knockdown increased or suppressed the migration ability of U87 cells, respectively. Furthermore, inhibition of basal activation of the AhR pathway suppressed migration ability, suggesting a positive correlation between endogenous activity of the AhR pathway and cell migration. When the AhR pathway was activated by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 6-formyl [3,2-b] carbazole (FICZ), the migration of U87 cells was inhibited by inducing the expression of a tumor suppressor, IL24, which is a downstream responsive gene of AhR activation. Moreover, a similar AhR-IL24-dependent mechanism for migration inhibition of TCDD was documented in a breast cancer cell line and a lung cancer cell line. This study demonstrated that AhR plays important roles in regulating the migration of glioblastoma, and the induction of the AhR-IL24 axis mediates the inhibition of migration in response to TCDD or FICZ treatment.http://www.sciencedirect.com/science/article/pii/S016041202100283XGlioblastomaAryl hydrocarbon receptorInterleukin 24Migration |