Impact of latent tuberculosis infection on health and wellbeing: a systematic review and meta-analysis
The impact of latent tuberculosis infection (LTBI) on health and wellbeing is not well understood. This review aims to evaluate the health and wellbeing of individuals with LTBI. A systematic literature search was performed to assess studies reporting patient-reported outcomes in LTBI management in...
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European Respiratory Society
2021-01-01
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doaj-bbb2ba9601df4e47b912fed0d28626c22021-03-31T12:29:30ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172021-01-013015910.1183/16000617.0260-20200260-2020Impact of latent tuberculosis infection on health and wellbeing: a systematic review and meta-analysisYen Jun Wong0Noorliza Mohd Noordin1Salmaan Keshavjee2Shaun Wen Huey Lee3 School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia National Public Health Laboratory, Ministry of Health, Sungai Buloh, Malaysia Dept of Global Health and Social Medicine, Harvard Medical School, Harvard University, Boston, MA, USA School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia The impact of latent tuberculosis infection (LTBI) on health and wellbeing is not well understood. This review aims to evaluate the health and wellbeing of individuals with LTBI. A systematic literature search was performed to assess studies reporting patient-reported outcomes in LTBI management including health-related quality of life (HRQoL), health utilities, disease burden and experience of individuals with LTBI. A pooled analysis was performed to estimate the effect of LTBI on HRQoL. A total of 4464 studies were screened, of which 13 eligible articles describing nine unique studies were included for review. The HRQoL of individuals with LTBI and without tuberculosis (TB) infection were comparable, and better than patients with active TB disease. However, individuals with LTBI reported poorer mental health compared with individuals without TB infection (mean difference −4.16, 95% CI −7.45– −0.87; p=0.01). Qualitative studies suggest the presence of fear, anxiety and stigma in individuals with LTBI. This review highlights potential psychosocial challenges in individuals with LTBI despite the absence of clinical symptoms. While their quality of life was marginally affected, this could be evidence to support LTBI management in preventing TB re-activation and the severe consequences of active TB disease that affect all domains of HRQoL.http://err.ersjournals.com/content/30/159/200260.full |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yen Jun Wong Noorliza Mohd Noordin Salmaan Keshavjee Shaun Wen Huey Lee |
spellingShingle |
Yen Jun Wong Noorliza Mohd Noordin Salmaan Keshavjee Shaun Wen Huey Lee Impact of latent tuberculosis infection on health and wellbeing: a systematic review and meta-analysis European Respiratory Review |
author_facet |
Yen Jun Wong Noorliza Mohd Noordin Salmaan Keshavjee Shaun Wen Huey Lee |
author_sort |
Yen Jun Wong |
title |
Impact of latent tuberculosis infection on health and wellbeing: a systematic review and meta-analysis |
title_short |
Impact of latent tuberculosis infection on health and wellbeing: a systematic review and meta-analysis |
title_full |
Impact of latent tuberculosis infection on health and wellbeing: a systematic review and meta-analysis |
title_fullStr |
Impact of latent tuberculosis infection on health and wellbeing: a systematic review and meta-analysis |
title_full_unstemmed |
Impact of latent tuberculosis infection on health and wellbeing: a systematic review and meta-analysis |
title_sort |
impact of latent tuberculosis infection on health and wellbeing: a systematic review and meta-analysis |
publisher |
European Respiratory Society |
series |
European Respiratory Review |
issn |
0905-9180 1600-0617 |
publishDate |
2021-01-01 |
description |
The impact of latent tuberculosis infection (LTBI) on health and wellbeing is not well understood. This review aims to evaluate the health and wellbeing of individuals with LTBI.
A systematic literature search was performed to assess studies reporting patient-reported outcomes in LTBI management including health-related quality of life (HRQoL), health utilities, disease burden and experience of individuals with LTBI. A pooled analysis was performed to estimate the effect of LTBI on HRQoL. A total of 4464 studies were screened, of which 13 eligible articles describing nine unique studies were included for review. The HRQoL of individuals with LTBI and without tuberculosis (TB) infection were comparable, and better than patients with active TB disease. However, individuals with LTBI reported poorer mental health compared with individuals without TB infection (mean difference −4.16, 95% CI −7.45– −0.87; p=0.01). Qualitative studies suggest the presence of fear, anxiety and stigma in individuals with LTBI. This review highlights potential psychosocial challenges in individuals with LTBI despite the absence of clinical symptoms. While their quality of life was marginally affected, this could be evidence to support LTBI management in preventing TB re-activation and the severe consequences of active TB disease that affect all domains of HRQoL. |
url |
http://err.ersjournals.com/content/30/159/200260.full |
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