Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases
This review covers current knowledge of selenium in the dietary intake, its bioavailability, metabolism, functions, biomarkers, supplementation and toxicity, as well as its relationship with diseases and gut microbiota specifically on the symbiotic relationship between gut microflora and selenium st...
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doaj-bbb2be61884843d0a10d29a363a8ef1c2021-06-04T04:28:27ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2021-06-01810.3389/fnut.2021.685317685317Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With DiseasesRannapaula Lawrynhuk Urbano Ferreira0Karine Cavalcanti Maurício Sena-Evangelista1Karine Cavalcanti Maurício Sena-Evangelista2Eduardo Pereira de Azevedo3Francisco Irochima Pinheiro4Francisco Irochima Pinheiro5Ricardo Ney Cobucci6Ricardo Ney Cobucci7Lucia Fatima Campos Pedrosa8Lucia Fatima Campos Pedrosa9Postgraduate Program in Nutrition, Federal University of Rio Grande do Norte, Natal, BrazilPostgraduate Program in Nutrition, Federal University of Rio Grande do Norte, Natal, BrazilDepartment of Nutrition, Federal University of Rio Grande do Norte, Natal, BrazilGraduate Program of Biotechnology, Laureate International Universities - Universidade Potiguar, Natal, BrazilGraduate Program of Biotechnology, Laureate International Universities - Universidade Potiguar, Natal, BrazilMedical School, Laureate International Universities - Universidade Potiguar, Natal, BrazilGraduate Program of Biotechnology, Laureate International Universities - Universidade Potiguar, Natal, BrazilMedical School, Laureate International Universities - Universidade Potiguar, Natal, BrazilPostgraduate Program in Nutrition, Federal University of Rio Grande do Norte, Natal, BrazilDepartment of Nutrition, Federal University of Rio Grande do Norte, Natal, BrazilThis review covers current knowledge of selenium in the dietary intake, its bioavailability, metabolism, functions, biomarkers, supplementation and toxicity, as well as its relationship with diseases and gut microbiota specifically on the symbiotic relationship between gut microflora and selenium status. Selenium is essential for the maintenance of the immune system, conversion of thyroid hormones, protection against the harmful action of heavy metals and xenobiotics as well as for the reduction of the risk of chronic diseases. Selenium is able to balance the microbial flora avoiding health damage associated with dysbiosis. Experimental studies have shown that inorganic and organic selenocompounds are metabolized to selenomethionine and incorporated by bacteria from the gut microflora, therefore highlighting their role in improving the bioavailability of selenocompounds. Dietary selenium can affect the gut microbial colonization, which in turn influences the host's selenium status and expression of selenoproteoma. Selenium deficiency may result in a phenotype of gut microbiota that is more susceptible to cancer, thyroid dysfunctions, inflammatory bowel disease, and cardiovascular disorders. Although the host and gut microbiota benefit each other from their symbiotic relationship, they may become competitors if the supply of micronutrients is limited. Intestinal bacteria can remove selenium from the host resulting in two to three times lower levels of host's selenoproteins under selenium-limiting conditions. There are still gaps in whether these consequences are unfavorable to humans and animals or whether the daily intake of selenium is also adapted to meet the needs of the bacteria.https://www.frontiersin.org/articles/10.3389/fnut.2021.685317/fullseleniumgut microbiotaselenocompoundsselenoproteinsselenium metabolism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rannapaula Lawrynhuk Urbano Ferreira Karine Cavalcanti Maurício Sena-Evangelista Karine Cavalcanti Maurício Sena-Evangelista Eduardo Pereira de Azevedo Francisco Irochima Pinheiro Francisco Irochima Pinheiro Ricardo Ney Cobucci Ricardo Ney Cobucci Lucia Fatima Campos Pedrosa Lucia Fatima Campos Pedrosa |
spellingShingle |
Rannapaula Lawrynhuk Urbano Ferreira Karine Cavalcanti Maurício Sena-Evangelista Karine Cavalcanti Maurício Sena-Evangelista Eduardo Pereira de Azevedo Francisco Irochima Pinheiro Francisco Irochima Pinheiro Ricardo Ney Cobucci Ricardo Ney Cobucci Lucia Fatima Campos Pedrosa Lucia Fatima Campos Pedrosa Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases Frontiers in Nutrition selenium gut microbiota selenocompounds selenoproteins selenium metabolism |
author_facet |
Rannapaula Lawrynhuk Urbano Ferreira Karine Cavalcanti Maurício Sena-Evangelista Karine Cavalcanti Maurício Sena-Evangelista Eduardo Pereira de Azevedo Francisco Irochima Pinheiro Francisco Irochima Pinheiro Ricardo Ney Cobucci Ricardo Ney Cobucci Lucia Fatima Campos Pedrosa Lucia Fatima Campos Pedrosa |
author_sort |
Rannapaula Lawrynhuk Urbano Ferreira |
title |
Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases |
title_short |
Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases |
title_full |
Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases |
title_fullStr |
Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases |
title_full_unstemmed |
Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases |
title_sort |
selenium in human health and gut microflora: bioavailability of selenocompounds and relationship with diseases |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Nutrition |
issn |
2296-861X |
publishDate |
2021-06-01 |
description |
This review covers current knowledge of selenium in the dietary intake, its bioavailability, metabolism, functions, biomarkers, supplementation and toxicity, as well as its relationship with diseases and gut microbiota specifically on the symbiotic relationship between gut microflora and selenium status. Selenium is essential for the maintenance of the immune system, conversion of thyroid hormones, protection against the harmful action of heavy metals and xenobiotics as well as for the reduction of the risk of chronic diseases. Selenium is able to balance the microbial flora avoiding health damage associated with dysbiosis. Experimental studies have shown that inorganic and organic selenocompounds are metabolized to selenomethionine and incorporated by bacteria from the gut microflora, therefore highlighting their role in improving the bioavailability of selenocompounds. Dietary selenium can affect the gut microbial colonization, which in turn influences the host's selenium status and expression of selenoproteoma. Selenium deficiency may result in a phenotype of gut microbiota that is more susceptible to cancer, thyroid dysfunctions, inflammatory bowel disease, and cardiovascular disorders. Although the host and gut microbiota benefit each other from their symbiotic relationship, they may become competitors if the supply of micronutrients is limited. Intestinal bacteria can remove selenium from the host resulting in two to three times lower levels of host's selenoproteins under selenium-limiting conditions. There are still gaps in whether these consequences are unfavorable to humans and animals or whether the daily intake of selenium is also adapted to meet the needs of the bacteria. |
topic |
selenium gut microbiota selenocompounds selenoproteins selenium metabolism |
url |
https://www.frontiersin.org/articles/10.3389/fnut.2021.685317/full |
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