Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles

Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles

Cell membrane coating of nanomaterials has become an attractive method of improving targeting, residence and biocompatibility. Here, the authors demonstrated that most nanoparticles are only partially coated by standard methods, and show the coating degree can impact the biological fate of nanoparti...

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Main Authors: Lizhi Liu, Xuan Bai, Maria-Viola Martikainen, Anna Kårlund, Marjut Roponen, Wujun Xu, Guoqing Hu, Ennio Tasciotti, Vesa-Pekka Lehto
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26052-x
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spelling doaj-bbbb6cca9f2f42dcb9eebca5da1a48a82021-10-03T11:50:52ZengNature Publishing GroupNature Communications2041-17232021-09-0112111210.1038/s41467-021-26052-xCell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticlesLizhi Liu0Xuan Bai1Maria-Viola Martikainen2Anna Kårlund3Marjut Roponen4Wujun Xu5Guoqing Hu6Ennio Tasciotti7Vesa-Pekka Lehto8Department of Applied Physics, University of Eastern FinlandDepartment of Engineering Mechanics, State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang UniversityDepartment of Environmental and Biological Sciences, University of Eastern FinlandInstitute of Public Health and Clinical Nutrition, University of Eastern FinlandDepartment of Environmental and Biological Sciences, University of Eastern FinlandDepartment of Applied Physics, University of Eastern FinlandDepartment of Engineering Mechanics, State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang UniversityIRCCS San Raffaele Pisana Hospital and San Raffaele UniversityDepartment of Applied Physics, University of Eastern FinlandCell membrane coating of nanomaterials has become an attractive method of improving targeting, residence and biocompatibility. Here, the authors demonstrated that most nanoparticles are only partially coated by standard methods, and show the coating degree can impact the biological fate of nanoparticles.https://doi.org/10.1038/s41467-021-26052-x
collection DOAJ
language English
format Article
sources DOAJ
author Lizhi Liu
Xuan Bai
Maria-Viola Martikainen
Anna Kårlund
Marjut Roponen
Wujun Xu
Guoqing Hu
Ennio Tasciotti
Vesa-Pekka Lehto
spellingShingle Lizhi Liu
Xuan Bai
Maria-Viola Martikainen
Anna Kårlund
Marjut Roponen
Wujun Xu
Guoqing Hu
Ennio Tasciotti
Vesa-Pekka Lehto
Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles
Nature Communications
author_facet Lizhi Liu
Xuan Bai
Maria-Viola Martikainen
Anna Kårlund
Marjut Roponen
Wujun Xu
Guoqing Hu
Ennio Tasciotti
Vesa-Pekka Lehto
author_sort Lizhi Liu
title Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles
title_short Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles
title_full Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles
title_fullStr Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles
title_full_unstemmed Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles
title_sort cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-09-01
description Cell membrane coating of nanomaterials has become an attractive method of improving targeting, residence and biocompatibility. Here, the authors demonstrated that most nanoparticles are only partially coated by standard methods, and show the coating degree can impact the biological fate of nanoparticles.
url https://doi.org/10.1038/s41467-021-26052-x
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AT xuanbai cellmembranecoatingintegrityaffectstheinternalizationmechanismofbiomimeticnanoparticles
AT mariaviolamartikainen cellmembranecoatingintegrityaffectstheinternalizationmechanismofbiomimeticnanoparticles
AT annakarlund cellmembranecoatingintegrityaffectstheinternalizationmechanismofbiomimeticnanoparticles
AT marjutroponen cellmembranecoatingintegrityaffectstheinternalizationmechanismofbiomimeticnanoparticles
AT wujunxu cellmembranecoatingintegrityaffectstheinternalizationmechanismofbiomimeticnanoparticles
AT guoqinghu cellmembranecoatingintegrityaffectstheinternalizationmechanismofbiomimeticnanoparticles
AT enniotasciotti cellmembranecoatingintegrityaffectstheinternalizationmechanismofbiomimeticnanoparticles
AT vesapekkalehto cellmembranecoatingintegrityaffectstheinternalizationmechanismofbiomimeticnanoparticles
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