Effect of NIPPV combined with respiratory stimulant therapy on serum markers in COPD patients with mild pulmonary encephalopathy

• Main Authors: Li Chen, Ying-Jia Lu
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-05-01
• Series: Journal of Hainan Medical University
• Subjects: COPD; Pulmonary encephalopathy; NIPPV; Respiratory stimulant
• Online Access: http://www.hnykdxxb.com/PDF/201610/7.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To analyze the effect of NIPPV combined with respiratory stimulant therapy on serum markers in COPD patients with mild pulmonary encephalopathy. Methods: A total of 102 cases of COPD patients with mild pulmonary encephalopathy who were hospitalized in our hospital from November 2012 to February 2015 were selected as research subjects and divided into observation group 51 cases and control group 51 cases according to the different clinical treatment they received. Control group received respiratory stimulant therapy alone, observation group received NIPPV combined with respiratory stimulant therapy, and then differences in arterial blood gas, serum AngⅡ, CPK, LDH, IL-6, IL-8 and IL-10 levels, S-100β, NSE, MBP, T-SOD and MDA levels as well as T3, T4 and TSH levels were compared between two groups. Results: PH value and PaO2 value of observation group after treatment were higher than those of control group, and PaCO2 level was lower than that of control group; serum AngⅡ, CPK, LDH, IL-6, IL-8 and IL-10 levels of observation group after treatment were lower than those of control group; serum S-100β, NSE, MBP and MDA levels of observation group after treatment were lower than those of control group, and T-SOD level was higher than that of control group; serum T3, T4 and TSH levels of observation group after treatment were higher than those of control group. Conclusion: NIPPV combined with respiratory stimulant therapy for COPD patients with mild pulmonary encephalopathy can effectively optimize respiratory function and equilibrate body fluid environment, and it has active clinical significance.