Are the Symptoms of an NSAID-Induced Ulcer Truly Milder Than Those of an Ordinary Ulcer?
Objective. The percentage of patients with nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin- (LDA-) induced ulcers who complain of gastrointestinal symptoms has generally been considered to be low. The aim of this study was to examine and compare the symptoms and quality of life (Q...
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doaj-bbcabc53beb346e186b901f58f27e49d2020-11-24T22:25:27ZengHindawi LimitedGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/46532504653250Are the Symptoms of an NSAID-Induced Ulcer Truly Milder Than Those of an Ordinary Ulcer?Toshihiko Tomita0Sumire Mori1Katsuyuki Tozawa2Eitatsu Arai3Nobuo Tano4Hideo Oka5Yongmin Kim6Takashi Abe7Yoshio Ohda8Tadayuki Oshima9Hirokazu Fukui10Jiro Watari11Hiroto Miwa12Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, JapanDivision of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, JapanDivision of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, JapanDepartment of Internal Medicine, Nishinomiya Kyoritsu Neurosurgical Hospital, Hyogo, JapanDepartment of Internal Medicine, Kyoritsu Hospital, Hyogo, JapanDepartment of Internal Medicine, Amagasaki Central Hospital, Hyogo, JapanDivision of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, JapanDivision of Gastroenterology, Takarazuka Municipal Hospital, Hyogo, JapanDivision of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, JapanDivision of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, JapanDivision of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, JapanDivision of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, JapanDivision of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, JapanObjective. The percentage of patients with nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin- (LDA-) induced ulcers who complain of gastrointestinal symptoms has generally been considered to be low. The aim of this study was to examine and compare the symptoms and quality of life (QOL) at peptic ulcer onset. Methods. This study involved 200 patients who were confirmed by endoscopy to be in the acute stage of gastroduodenal ulcer (A1-H1). Patients completed a self-administered questionnaire (Global Overall Symptom score and SF-8) at ulcer onset, and data were compared between NSAIDs/LDA ulcers and non-NSAIDs/LDA ulcers. Results. The upper gastrointestinal symptoms score was significantly lower for patients using LDA only (20.5 ± 9.4 in the nonusing group, 19.6 ± 8.6 in the NSAIDs-only group, 16.7 ± 11.6 in the LDA-only group, and 18.5 ± 7.2 in the NSAIDs/LDA group, P<0.05). The QOL score (physical summary) was significantly lower in the NSAID group (42.1 ± 9.9) than in the nonusing group (47.6 ± 7.6) (P<0.05). Patients’ characteristics showed no significant differences among the groups, with the exception of age. Conclusion. The severity of upper abdominal symptoms at peptic ulcer onset was similar between NSAID users and nonusers.http://dx.doi.org/10.1155/2017/4653250 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Toshihiko Tomita Sumire Mori Katsuyuki Tozawa Eitatsu Arai Nobuo Tano Hideo Oka Yongmin Kim Takashi Abe Yoshio Ohda Tadayuki Oshima Hirokazu Fukui Jiro Watari Hiroto Miwa |
spellingShingle |
Toshihiko Tomita Sumire Mori Katsuyuki Tozawa Eitatsu Arai Nobuo Tano Hideo Oka Yongmin Kim Takashi Abe Yoshio Ohda Tadayuki Oshima Hirokazu Fukui Jiro Watari Hiroto Miwa Are the Symptoms of an NSAID-Induced Ulcer Truly Milder Than Those of an Ordinary Ulcer? Gastroenterology Research and Practice |
author_facet |
Toshihiko Tomita Sumire Mori Katsuyuki Tozawa Eitatsu Arai Nobuo Tano Hideo Oka Yongmin Kim Takashi Abe Yoshio Ohda Tadayuki Oshima Hirokazu Fukui Jiro Watari Hiroto Miwa |
author_sort |
Toshihiko Tomita |
title |
Are the Symptoms of an NSAID-Induced Ulcer Truly Milder Than Those of an Ordinary Ulcer? |
title_short |
Are the Symptoms of an NSAID-Induced Ulcer Truly Milder Than Those of an Ordinary Ulcer? |
title_full |
Are the Symptoms of an NSAID-Induced Ulcer Truly Milder Than Those of an Ordinary Ulcer? |
title_fullStr |
Are the Symptoms of an NSAID-Induced Ulcer Truly Milder Than Those of an Ordinary Ulcer? |
title_full_unstemmed |
Are the Symptoms of an NSAID-Induced Ulcer Truly Milder Than Those of an Ordinary Ulcer? |
title_sort |
are the symptoms of an nsaid-induced ulcer truly milder than those of an ordinary ulcer? |
publisher |
Hindawi Limited |
series |
Gastroenterology Research and Practice |
issn |
1687-6121 1687-630X |
publishDate |
2017-01-01 |
description |
Objective. The percentage of patients with nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin- (LDA-) induced ulcers who complain of gastrointestinal symptoms has generally been considered to be low. The aim of this study was to examine and compare the symptoms and quality of life (QOL) at peptic ulcer onset. Methods. This study involved 200 patients who were confirmed by endoscopy to be in the acute stage of gastroduodenal ulcer (A1-H1). Patients completed a self-administered questionnaire (Global Overall Symptom score and SF-8) at ulcer onset, and data were compared between NSAIDs/LDA ulcers and non-NSAIDs/LDA ulcers. Results. The upper gastrointestinal symptoms score was significantly lower for patients using LDA only (20.5 ± 9.4 in the nonusing group, 19.6 ± 8.6 in the NSAIDs-only group, 16.7 ± 11.6 in the LDA-only group, and 18.5 ± 7.2 in the NSAIDs/LDA group, P<0.05). The QOL score (physical summary) was significantly lower in the NSAID group (42.1 ± 9.9) than in the nonusing group (47.6 ± 7.6) (P<0.05). Patients’ characteristics showed no significant differences among the groups, with the exception of age. Conclusion. The severity of upper abdominal symptoms at peptic ulcer onset was similar between NSAID users and nonusers. |
url |
http://dx.doi.org/10.1155/2017/4653250 |
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