Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer
Objective: The early and local advanced stages (IA-IIIA) of non-small cell lung cancer (NSCLC) warrant the curative treatment approach of surgery. However, despite the surgical approach, survival depends on a number of factors. The aim of the study was to examine the factors that affect survival in...
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doaj-bbd21980f86443aa8189912aaaf489d32021-09-02T07:43:50ZengModestum Publishing LTDJournal of Clinical and Experimental Investigations1309-66211309-85782016-06-0172125513310.5799/ahinjs.01.2016.02.0584Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung CancerMahsuk Taylan0Sibel Arinc 1Aysun Kosif Misirlioglu 2Sinan Bodur 3Selahattin Oztas 4Mevlut Karatas 5İlim İrmak 6Huseyin Arpag 7Armagan Hazar8Dicle University Faculty of Medicine, Department of Chest Disease, 21020 Diyarbakir, TurkeySureyyapasa Training and Research Hospital, Department of Chest Disease, 34854 İstanbul, TurkeySureyyapasa Training and Research Hospital, Department of Chest Surgery, 34854 İstanbul, TurkeySureyyapasa Training and Research Hospital, Department of Chest Disease, 34854 İstanbul, TurkeySureyyapasa Training and Research Hospital, Department of Chest Disease, 34854 İstanbul, TurkeyRecep Tayyip Erdogan University Faculty of Medicine, Department of Chest Disease, 5300 Rize, TurkeySureyyapasa Training and Research Hospital, Department of Chest Disease, 34854 İstanbul, TurkeySutcu Imam University Faculty of Medicine, Department of Chest Disease, 46100 Kahramanmaras, TurkeySureyyapasa Training and Research Hospital, Department of Chest Disease, 34854 İstanbul, Turkey Objective: The early and local advanced stages (IA-IIIA) of non-small cell lung cancer (NSCLC) warrant the curative treatment approach of surgery. However, despite the surgical approach, survival depends on a number of factors. The aim of the study was to examine the factors that affect survival in operated NSCLC patients with these stages. Methods: A cohort of 231 operated patients with IA, IB, IIA, IIB, and IIIA stages of NSCLC were analyzed. The effects of age, sex, comorbidity, performance status, histopathology of the tumor, T stage, N stage, pleural invasion, surgical resection type and postoperative resection margin invasion on the survival of the patients were examined with Kaplan-Meier and Cox Regression analyses. Results: Advanced age (OR=1.042 for every passing year, CI=1.020-1.064), adenocarcinoma histopathology (OR=1.676 CI=1.178-2.384), N2 invasion (OR=2.389 CI=1.46-4.239), pleural invasion (OR=2.403 CI=1.569-3.678), resection margin invasion (OR=2.401, CI=1.141-5.048) and pneumonectomy as the type of surgical operation (OR=2.313, CI=1.467-3.647) were found to be independent prognostic factors of mortality. Conclusion: Follow-up of the NSCLC cases with advanced age, an adenocarcinoma type, visceral pleural invasion, N2-lymph node invasion, a history of pneumonectomy, and a resection margin invasion should be undertaken more attentively during planning of surgical operation and postoperative period. J Clin Exp Invest 2016; 7 (2): 125-133http://jceionline.org/upload/sayi/31/JCEI-01297.pdfSurvivalmortalityperformance scoreoperated |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mahsuk Taylan Sibel Arinc Aysun Kosif Misirlioglu Sinan Bodur Selahattin Oztas Mevlut Karatas İlim İrmak Huseyin Arpag Armagan Hazar |
spellingShingle |
Mahsuk Taylan Sibel Arinc Aysun Kosif Misirlioglu Sinan Bodur Selahattin Oztas Mevlut Karatas İlim İrmak Huseyin Arpag Armagan Hazar Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer Journal of Clinical and Experimental Investigations Survival mortality performance score operated |
author_facet |
Mahsuk Taylan Sibel Arinc Aysun Kosif Misirlioglu Sinan Bodur Selahattin Oztas Mevlut Karatas İlim İrmak Huseyin Arpag Armagan Hazar |
author_sort |
Mahsuk Taylan |
title |
Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer |
title_short |
Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer |
title_full |
Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer |
title_fullStr |
Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer |
title_full_unstemmed |
Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer |
title_sort |
survival in operated early and local advanced-stage (ia-iiia) non-small cell lung cancer |
publisher |
Modestum Publishing LTD |
series |
Journal of Clinical and Experimental Investigations |
issn |
1309-6621 1309-8578 |
publishDate |
2016-06-01 |
description |
Objective: The early and local advanced stages (IA-IIIA) of non-small cell lung cancer (NSCLC) warrant the curative treatment approach of surgery. However, despite the surgical approach, survival depends on a number of factors. The aim of the study was to examine the factors that affect survival in operated NSCLC patients with these stages.
Methods: A cohort of 231 operated patients with IA, IB, IIA, IIB, and IIIA stages of NSCLC were analyzed. The effects of age, sex, comorbidity, performance status, histopathology of the tumor, T stage, N stage, pleural invasion, surgical resection type and postoperative resection margin invasion on the survival of the patients were examined with Kaplan-Meier and Cox Regression analyses.
Results: Advanced age (OR=1.042 for every passing year, CI=1.020-1.064), adenocarcinoma histopathology (OR=1.676 CI=1.178-2.384), N2 invasion (OR=2.389 CI=1.46-4.239), pleural invasion (OR=2.403 CI=1.569-3.678), resection margin invasion (OR=2.401, CI=1.141-5.048) and pneumonectomy as the type of surgical operation (OR=2.313, CI=1.467-3.647) were found to be independent prognostic factors of mortality.
Conclusion: Follow-up of the NSCLC cases with advanced age, an adenocarcinoma type, visceral pleural invasion, N2-lymph node invasion, a history of pneumonectomy, and a resection margin invasion should be undertaken more attentively during planning of surgical operation and postoperative period. J Clin Exp Invest 2016; 7 (2): 125-133 |
topic |
Survival mortality performance score operated |
url |
http://jceionline.org/upload/sayi/31/JCEI-01297.pdf |
work_keys_str_mv |
AT mahsuktaylan survivalinoperatedearlyandlocaladvancedstageiaiiianonsmallcelllungcancer AT sibelarinc survivalinoperatedearlyandlocaladvancedstageiaiiianonsmallcelllungcancer AT aysunkosifmisirlioglu survivalinoperatedearlyandlocaladvancedstageiaiiianonsmallcelllungcancer AT sinanbodur survivalinoperatedearlyandlocaladvancedstageiaiiianonsmallcelllungcancer AT selahattinoztas survivalinoperatedearlyandlocaladvancedstageiaiiianonsmallcelllungcancer AT mevlutkaratas survivalinoperatedearlyandlocaladvancedstageiaiiianonsmallcelllungcancer AT ilimirmak survivalinoperatedearlyandlocaladvancedstageiaiiianonsmallcelllungcancer AT huseyinarpag survivalinoperatedearlyandlocaladvancedstageiaiiianonsmallcelllungcancer AT armaganhazar survivalinoperatedearlyandlocaladvancedstageiaiiianonsmallcelllungcancer |
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