The Effects of Levodopa and Deep Brain Stimulation on Subthalamic Local Field Low-Frequency Oscillations in Parkinson's Disease
New adaptive systems for deep brain stimulation (DBS) could in the near future optimize stimulation settings online so as to achieve better control over the clinical fluctuations in Parkinson's disease (PD). Local field potentials (LFPs) recorded from the subthalamic nucleus (STN) in PD patient...
Main Authors: | , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Cell Physiol Biochem Press GmbH & Co KG
2012-04-01
|
Series: | Neurosignals |
Subjects: | |
Online Access: | http://www.karger.com/Article/FullText/336543 |
id |
doaj-bbd3948f4a8c429285ac92162664302d |
---|---|
record_format |
Article |
spelling |
doaj-bbd3948f4a8c429285ac92162664302d2020-11-25T03:58:35ZengCell Physiol Biochem Press GmbH & Co KGNeurosignals1424-862X1424-86382012-04-01211-2899810.1159/000336543336543The Effects of Levodopa and Deep Brain Stimulation on Subthalamic Local Field Low-Frequency Oscillations in Parkinson's DiseaseGaia GiannicolaManuela RosaSara MarcegliaEmma ScelzoLorenzo RossiDomenico ServelloClaudia MenghettiClaudio PacchettiRoberta ZangagliaMarco LocatelliElena CaputoFilippo CogiamanianGianluca ArdolinoSergio BarbieriAlberto PrioriNew adaptive systems for deep brain stimulation (DBS) could in the near future optimize stimulation settings online so as to achieve better control over the clinical fluctuations in Parkinson's disease (PD). Local field potentials (LFPs) recorded from the subthalamic nucleus (STN) in PD patients show that levodopa and DBS modulate STN oscillations. Because previous research has shown that levodopa and DBS variably influence beta LFP activity (8-20 Hz), we designed this study to find out how they affect low-frequency (LF) oscillations (2-7 Hz). STN LFPs were recorded in 19 patients with PD during DBS, after levodopa medication, and during DBS and levodopa intake combined. We investigated the relationship between LF modulations, DBS duration and levodopa intake. We also studied whether LF power depended on disease severity, the patient's clinical condition and whether LF modulations were related to electrode impedances. LF power increased during DBS, after levodopa intake and under both experimental conditions combined. The LF power increase correlated with the levodopa-induced clinical improvement and the higher the electrode impedance, the greater was the LF power change. These data suggest that the LF band could be useful as a control neurosignal for developing novel adaptive DBS systems for patients with PD.http://www.karger.com/Article/FullText/336543LevodopaLocal field potentialsLow frequencyParkinson’s diseaseSubthalamic nucleusDeep brain stimulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gaia Giannicola Manuela Rosa Sara Marceglia Emma Scelzo Lorenzo Rossi Domenico Servello Claudia Menghetti Claudio Pacchetti Roberta Zangaglia Marco Locatelli Elena Caputo Filippo Cogiamanian Gianluca Ardolino Sergio Barbieri Alberto Priori |
spellingShingle |
Gaia Giannicola Manuela Rosa Sara Marceglia Emma Scelzo Lorenzo Rossi Domenico Servello Claudia Menghetti Claudio Pacchetti Roberta Zangaglia Marco Locatelli Elena Caputo Filippo Cogiamanian Gianluca Ardolino Sergio Barbieri Alberto Priori The Effects of Levodopa and Deep Brain Stimulation on Subthalamic Local Field Low-Frequency Oscillations in Parkinson's Disease Neurosignals Levodopa Local field potentials Low frequency Parkinson’s disease Subthalamic nucleus Deep brain stimulation |
author_facet |
Gaia Giannicola Manuela Rosa Sara Marceglia Emma Scelzo Lorenzo Rossi Domenico Servello Claudia Menghetti Claudio Pacchetti Roberta Zangaglia Marco Locatelli Elena Caputo Filippo Cogiamanian Gianluca Ardolino Sergio Barbieri Alberto Priori |
author_sort |
Gaia Giannicola |
title |
The Effects of Levodopa and Deep Brain Stimulation on Subthalamic Local Field Low-Frequency Oscillations in Parkinson's Disease |
title_short |
The Effects of Levodopa and Deep Brain Stimulation on Subthalamic Local Field Low-Frequency Oscillations in Parkinson's Disease |
title_full |
The Effects of Levodopa and Deep Brain Stimulation on Subthalamic Local Field Low-Frequency Oscillations in Parkinson's Disease |
title_fullStr |
The Effects of Levodopa and Deep Brain Stimulation on Subthalamic Local Field Low-Frequency Oscillations in Parkinson's Disease |
title_full_unstemmed |
The Effects of Levodopa and Deep Brain Stimulation on Subthalamic Local Field Low-Frequency Oscillations in Parkinson's Disease |
title_sort |
effects of levodopa and deep brain stimulation on subthalamic local field low-frequency oscillations in parkinson's disease |
publisher |
Cell Physiol Biochem Press GmbH & Co KG |
series |
Neurosignals |
issn |
1424-862X 1424-8638 |
publishDate |
2012-04-01 |
description |
New adaptive systems for deep brain stimulation (DBS) could in the near future optimize stimulation settings online so as to achieve better control over the clinical fluctuations in Parkinson's disease (PD). Local field potentials (LFPs) recorded from the subthalamic nucleus (STN) in PD patients show that levodopa and DBS modulate STN oscillations. Because previous research has shown that levodopa and DBS variably influence beta LFP activity (8-20 Hz), we designed this study to find out how they affect low-frequency (LF) oscillations (2-7 Hz). STN LFPs were recorded in 19 patients with PD during DBS, after levodopa medication, and during DBS and levodopa intake combined. We investigated the relationship between LF modulations, DBS duration and levodopa intake. We also studied whether LF power depended on disease severity, the patient's clinical condition and whether LF modulations were related to electrode impedances. LF power increased during DBS, after levodopa intake and under both experimental conditions combined. The LF power increase correlated with the levodopa-induced clinical improvement and the higher the electrode impedance, the greater was the LF power change. These data suggest that the LF band could be useful as a control neurosignal for developing novel adaptive DBS systems for patients with PD. |
topic |
Levodopa Local field potentials Low frequency Parkinson’s disease Subthalamic nucleus Deep brain stimulation |
url |
http://www.karger.com/Article/FullText/336543 |
work_keys_str_mv |
AT gaiagiannicola theeffectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT manuelarosa theeffectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT saramarceglia theeffectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT emmascelzo theeffectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT lorenzorossi theeffectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT domenicoservello theeffectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT claudiamenghetti theeffectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT claudiopacchetti theeffectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT robertazangaglia theeffectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT marcolocatelli theeffectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT elenacaputo theeffectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT filippocogiamanian theeffectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT gianlucaardolino theeffectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT sergiobarbieri theeffectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT albertopriori theeffectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT gaiagiannicola effectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT manuelarosa effectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT saramarceglia effectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT emmascelzo effectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT lorenzorossi effectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT domenicoservello effectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT claudiamenghetti effectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT claudiopacchetti effectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT robertazangaglia effectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT marcolocatelli effectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT elenacaputo effectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT filippocogiamanian effectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT gianlucaardolino effectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT sergiobarbieri effectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease AT albertopriori effectsoflevodopaanddeepbrainstimulationonsubthalamiclocalfieldlowfrequencyoscillationsinparkinsonsdisease |
_version_ |
1724456311346692096 |