Salmonella uses energy taxis to benefit from intestinal inflammation.
Chemotaxis enhances the fitness of Salmonella enterica serotype Typhimurium (S. Typhimurium) during colitis. However, the chemotaxis receptors conferring this fitness advantage and their cognate signals generated during inflammation remain unknown. Here we identify respiratory electron acceptors tha...
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2013-01-01
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doaj-bbd7b0e0365644088860af1bcd8a88082020-11-25T01:35:06ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742013-01-0194e100326710.1371/journal.ppat.1003267Salmonella uses energy taxis to benefit from intestinal inflammation.Fabian Rivera-ChávezSebastian E WinterChristopher A LopezMariana N XavierMaria G WinterSean-Paul NuccioJoseph M RussellRichard C LaughlinSara D LawhonTorsten SterzenbachCharles L BevinsRenée M TsolisRasika HarsheyL Garry AdamsAndreas J BäumlerChemotaxis enhances the fitness of Salmonella enterica serotype Typhimurium (S. Typhimurium) during colitis. However, the chemotaxis receptors conferring this fitness advantage and their cognate signals generated during inflammation remain unknown. Here we identify respiratory electron acceptors that are generated in the intestinal lumen as by-products of the host inflammatory response as in vivo signals for methyl-accepting chemotaxis proteins (MCPs). Three MCPs, including Trg, Tsr and Aer, enhanced the fitness of S. Typhimurium in a mouse colitis model. Aer mediated chemotaxis towards electron acceptors (energy taxis) in vitro and required tetrathionate respiration to confer a fitness advantage in vivo. Tsr mediated energy taxis towards nitrate but not towards tetrathionate in vitro and required nitrate respiration to confer a fitness advantage in vivo. These data suggest that the energy taxis receptors Tsr and Aer respond to distinct in vivo signals to confer a fitness advantage upon S. Typhimurium during inflammation by enabling this facultative anaerobic pathogen to seek out favorable spatial niches containing host-derived electron acceptors that boost its luminal growth.http://europepmc.org/articles/PMC3630101?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fabian Rivera-Chávez Sebastian E Winter Christopher A Lopez Mariana N Xavier Maria G Winter Sean-Paul Nuccio Joseph M Russell Richard C Laughlin Sara D Lawhon Torsten Sterzenbach Charles L Bevins Renée M Tsolis Rasika Harshey L Garry Adams Andreas J Bäumler |
spellingShingle |
Fabian Rivera-Chávez Sebastian E Winter Christopher A Lopez Mariana N Xavier Maria G Winter Sean-Paul Nuccio Joseph M Russell Richard C Laughlin Sara D Lawhon Torsten Sterzenbach Charles L Bevins Renée M Tsolis Rasika Harshey L Garry Adams Andreas J Bäumler Salmonella uses energy taxis to benefit from intestinal inflammation. PLoS Pathogens |
author_facet |
Fabian Rivera-Chávez Sebastian E Winter Christopher A Lopez Mariana N Xavier Maria G Winter Sean-Paul Nuccio Joseph M Russell Richard C Laughlin Sara D Lawhon Torsten Sterzenbach Charles L Bevins Renée M Tsolis Rasika Harshey L Garry Adams Andreas J Bäumler |
author_sort |
Fabian Rivera-Chávez |
title |
Salmonella uses energy taxis to benefit from intestinal inflammation. |
title_short |
Salmonella uses energy taxis to benefit from intestinal inflammation. |
title_full |
Salmonella uses energy taxis to benefit from intestinal inflammation. |
title_fullStr |
Salmonella uses energy taxis to benefit from intestinal inflammation. |
title_full_unstemmed |
Salmonella uses energy taxis to benefit from intestinal inflammation. |
title_sort |
salmonella uses energy taxis to benefit from intestinal inflammation. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Pathogens |
issn |
1553-7366 1553-7374 |
publishDate |
2013-01-01 |
description |
Chemotaxis enhances the fitness of Salmonella enterica serotype Typhimurium (S. Typhimurium) during colitis. However, the chemotaxis receptors conferring this fitness advantage and their cognate signals generated during inflammation remain unknown. Here we identify respiratory electron acceptors that are generated in the intestinal lumen as by-products of the host inflammatory response as in vivo signals for methyl-accepting chemotaxis proteins (MCPs). Three MCPs, including Trg, Tsr and Aer, enhanced the fitness of S. Typhimurium in a mouse colitis model. Aer mediated chemotaxis towards electron acceptors (energy taxis) in vitro and required tetrathionate respiration to confer a fitness advantage in vivo. Tsr mediated energy taxis towards nitrate but not towards tetrathionate in vitro and required nitrate respiration to confer a fitness advantage in vivo. These data suggest that the energy taxis receptors Tsr and Aer respond to distinct in vivo signals to confer a fitness advantage upon S. Typhimurium during inflammation by enabling this facultative anaerobic pathogen to seek out favorable spatial niches containing host-derived electron acceptors that boost its luminal growth. |
url |
http://europepmc.org/articles/PMC3630101?pdf=render |
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