Salmonella uses energy taxis to benefit from intestinal inflammation.

Chemotaxis enhances the fitness of Salmonella enterica serotype Typhimurium (S. Typhimurium) during colitis. However, the chemotaxis receptors conferring this fitness advantage and their cognate signals generated during inflammation remain unknown. Here we identify respiratory electron acceptors tha...

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Main Authors: Fabian Rivera-Chávez, Sebastian E Winter, Christopher A Lopez, Mariana N Xavier, Maria G Winter, Sean-Paul Nuccio, Joseph M Russell, Richard C Laughlin, Sara D Lawhon, Torsten Sterzenbach, Charles L Bevins, Renée M Tsolis, Rasika Harshey, L Garry Adams, Andreas J Bäumler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3630101?pdf=render
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spelling doaj-bbd7b0e0365644088860af1bcd8a88082020-11-25T01:35:06ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742013-01-0194e100326710.1371/journal.ppat.1003267Salmonella uses energy taxis to benefit from intestinal inflammation.Fabian Rivera-ChávezSebastian E WinterChristopher A LopezMariana N XavierMaria G WinterSean-Paul NuccioJoseph M RussellRichard C LaughlinSara D LawhonTorsten SterzenbachCharles L BevinsRenée M TsolisRasika HarsheyL Garry AdamsAndreas J BäumlerChemotaxis enhances the fitness of Salmonella enterica serotype Typhimurium (S. Typhimurium) during colitis. However, the chemotaxis receptors conferring this fitness advantage and their cognate signals generated during inflammation remain unknown. Here we identify respiratory electron acceptors that are generated in the intestinal lumen as by-products of the host inflammatory response as in vivo signals for methyl-accepting chemotaxis proteins (MCPs). Three MCPs, including Trg, Tsr and Aer, enhanced the fitness of S. Typhimurium in a mouse colitis model. Aer mediated chemotaxis towards electron acceptors (energy taxis) in vitro and required tetrathionate respiration to confer a fitness advantage in vivo. Tsr mediated energy taxis towards nitrate but not towards tetrathionate in vitro and required nitrate respiration to confer a fitness advantage in vivo. These data suggest that the energy taxis receptors Tsr and Aer respond to distinct in vivo signals to confer a fitness advantage upon S. Typhimurium during inflammation by enabling this facultative anaerobic pathogen to seek out favorable spatial niches containing host-derived electron acceptors that boost its luminal growth.http://europepmc.org/articles/PMC3630101?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Fabian Rivera-Chávez
Sebastian E Winter
Christopher A Lopez
Mariana N Xavier
Maria G Winter
Sean-Paul Nuccio
Joseph M Russell
Richard C Laughlin
Sara D Lawhon
Torsten Sterzenbach
Charles L Bevins
Renée M Tsolis
Rasika Harshey
L Garry Adams
Andreas J Bäumler
spellingShingle Fabian Rivera-Chávez
Sebastian E Winter
Christopher A Lopez
Mariana N Xavier
Maria G Winter
Sean-Paul Nuccio
Joseph M Russell
Richard C Laughlin
Sara D Lawhon
Torsten Sterzenbach
Charles L Bevins
Renée M Tsolis
Rasika Harshey
L Garry Adams
Andreas J Bäumler
Salmonella uses energy taxis to benefit from intestinal inflammation.
PLoS Pathogens
author_facet Fabian Rivera-Chávez
Sebastian E Winter
Christopher A Lopez
Mariana N Xavier
Maria G Winter
Sean-Paul Nuccio
Joseph M Russell
Richard C Laughlin
Sara D Lawhon
Torsten Sterzenbach
Charles L Bevins
Renée M Tsolis
Rasika Harshey
L Garry Adams
Andreas J Bäumler
author_sort Fabian Rivera-Chávez
title Salmonella uses energy taxis to benefit from intestinal inflammation.
title_short Salmonella uses energy taxis to benefit from intestinal inflammation.
title_full Salmonella uses energy taxis to benefit from intestinal inflammation.
title_fullStr Salmonella uses energy taxis to benefit from intestinal inflammation.
title_full_unstemmed Salmonella uses energy taxis to benefit from intestinal inflammation.
title_sort salmonella uses energy taxis to benefit from intestinal inflammation.
publisher Public Library of Science (PLoS)
series PLoS Pathogens
issn 1553-7366
1553-7374
publishDate 2013-01-01
description Chemotaxis enhances the fitness of Salmonella enterica serotype Typhimurium (S. Typhimurium) during colitis. However, the chemotaxis receptors conferring this fitness advantage and their cognate signals generated during inflammation remain unknown. Here we identify respiratory electron acceptors that are generated in the intestinal lumen as by-products of the host inflammatory response as in vivo signals for methyl-accepting chemotaxis proteins (MCPs). Three MCPs, including Trg, Tsr and Aer, enhanced the fitness of S. Typhimurium in a mouse colitis model. Aer mediated chemotaxis towards electron acceptors (energy taxis) in vitro and required tetrathionate respiration to confer a fitness advantage in vivo. Tsr mediated energy taxis towards nitrate but not towards tetrathionate in vitro and required nitrate respiration to confer a fitness advantage in vivo. These data suggest that the energy taxis receptors Tsr and Aer respond to distinct in vivo signals to confer a fitness advantage upon S. Typhimurium during inflammation by enabling this facultative anaerobic pathogen to seek out favorable spatial niches containing host-derived electron acceptors that boost its luminal growth.
url http://europepmc.org/articles/PMC3630101?pdf=render
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