Methods for Identification of CA125 from Ovarian Cancer Ascites by High Resolution Mass Spectrometry

Methods for Identification of CA125 from Ovarian Cancer Ascites by High Resolution Mass Spectrometry

CA125 is the most widely used tumour marker in ovarian cancer with unsatisfactory sensitivity and specificity especially at early stage. It is quantified by antibody-based immunoassays; however different molecular weight isoforms have been described in the literature which have never been validated...

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Bibliographic Details
Main Authors: Florian Weiland, Katarina Fritz, Peter Hoffmann, Martin K. Oehler
Format: Article
Language:English
Published: MDPI AG 2012-08-01
Series:International Journal of Molecular Sciences
Subjects:
CA125
mucin 16
mass spectrometry
ovarian cancer
antibody
false-positives
Online Access:http://www.mdpi.com/1422-0067/13/8/9942

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