Plasticity and Potency of Mammary Stem Cell Subsets During Mammary Gland Development
It is now widely believed that mammary epithelial cell plasticity, an important physiological process during the stages of mammary gland development, is exploited by the malignant cells for their successful disease progression. Normal mammary epithelial cells are heterogeneous and organized in hiera...
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doaj-bbf017f3e0414579b8239f3db9407add2020-11-25T01:18:01ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-05-01209235710.3390/ijms20092357ijms20092357Plasticity and Potency of Mammary Stem Cell Subsets During Mammary Gland DevelopmentEunmi Lee0Raziye Piranlioglu1Max S. Wicha2Hasan Korkaya3Department of Biochemistry and Molecular Biology, Georgia Cancer Center, Augusta University, Augusta, GA 30912, USADepartment of Biochemistry and Molecular Biology, Georgia Cancer Center, Augusta University, Augusta, GA 30912, USAComprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USADepartment of Biochemistry and Molecular Biology, Georgia Cancer Center, Augusta University, Augusta, GA 30912, USAIt is now widely believed that mammary epithelial cell plasticity, an important physiological process during the stages of mammary gland development, is exploited by the malignant cells for their successful disease progression. Normal mammary epithelial cells are heterogeneous and organized in hierarchical fashion, in which the mammary stem cells (MaSC) lie at the apex with regenerative capacity as well as plasticity. Despite the fact that the majority of studies supported the existence of multipotent MaSCs giving rise to both basal and luminal lineages, others proposed lineage restricted unipotent MaSCs. Consistent with the notion, the latest research has suggested that although normal MaSC subsets mainly stay in a quiescent state, they differ in their reconstituting ability, spatial localization, and molecular and epigenetic signatures in response to physiological stimuli within the respective microenvironment during the stages of mammary gland development. In this review, we will focus on current research on the biology of normal mammary stem cells with an emphasis on properties of cellular plasticity, self-renewal and quiescence, as well as the role of the microenvironment in regulating these processes. This will include a discussion of normal breast stem cell heterogeneity, stem cell markers, and lineage tracing studies.https://www.mdpi.com/1422-0067/20/9/2357mammary stem cellsmorphogenesisepithelial plasticitymultipotentunipotent |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eunmi Lee Raziye Piranlioglu Max S. Wicha Hasan Korkaya |
spellingShingle |
Eunmi Lee Raziye Piranlioglu Max S. Wicha Hasan Korkaya Plasticity and Potency of Mammary Stem Cell Subsets During Mammary Gland Development International Journal of Molecular Sciences mammary stem cells morphogenesis epithelial plasticity multipotent unipotent |
author_facet |
Eunmi Lee Raziye Piranlioglu Max S. Wicha Hasan Korkaya |
author_sort |
Eunmi Lee |
title |
Plasticity and Potency of Mammary Stem Cell Subsets During Mammary Gland Development |
title_short |
Plasticity and Potency of Mammary Stem Cell Subsets During Mammary Gland Development |
title_full |
Plasticity and Potency of Mammary Stem Cell Subsets During Mammary Gland Development |
title_fullStr |
Plasticity and Potency of Mammary Stem Cell Subsets During Mammary Gland Development |
title_full_unstemmed |
Plasticity and Potency of Mammary Stem Cell Subsets During Mammary Gland Development |
title_sort |
plasticity and potency of mammary stem cell subsets during mammary gland development |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-05-01 |
description |
It is now widely believed that mammary epithelial cell plasticity, an important physiological process during the stages of mammary gland development, is exploited by the malignant cells for their successful disease progression. Normal mammary epithelial cells are heterogeneous and organized in hierarchical fashion, in which the mammary stem cells (MaSC) lie at the apex with regenerative capacity as well as plasticity. Despite the fact that the majority of studies supported the existence of multipotent MaSCs giving rise to both basal and luminal lineages, others proposed lineage restricted unipotent MaSCs. Consistent with the notion, the latest research has suggested that although normal MaSC subsets mainly stay in a quiescent state, they differ in their reconstituting ability, spatial localization, and molecular and epigenetic signatures in response to physiological stimuli within the respective microenvironment during the stages of mammary gland development. In this review, we will focus on current research on the biology of normal mammary stem cells with an emphasis on properties of cellular plasticity, self-renewal and quiescence, as well as the role of the microenvironment in regulating these processes. This will include a discussion of normal breast stem cell heterogeneity, stem cell markers, and lineage tracing studies. |
topic |
mammary stem cells morphogenesis epithelial plasticity multipotent unipotent |
url |
https://www.mdpi.com/1422-0067/20/9/2357 |
work_keys_str_mv |
AT eunmilee plasticityandpotencyofmammarystemcellsubsetsduringmammaryglanddevelopment AT raziyepiranlioglu plasticityandpotencyofmammarystemcellsubsetsduringmammaryglanddevelopment AT maxswicha plasticityandpotencyofmammarystemcellsubsetsduringmammaryglanddevelopment AT hasankorkaya plasticityandpotencyofmammarystemcellsubsetsduringmammaryglanddevelopment |
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1725144209975934976 |