Exopolysaccharides isolated from hydrothermal vent bacteria can modulate the complement system.
The complement system is involved in the defence against bacterial infection, or in the elimination of tumour cells. However, disturbances in this system contributes to the pathogenesis of various inflammatory diseases. The efficiency of therapeutic anti-tumour antibodies is enhanced when the comple...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3988086?pdf=render |
id |
doaj-bbf0b19740234862a69983151ffd976f |
---|---|
record_format |
Article |
spelling |
doaj-bbf0b19740234862a69983151ffd976f2020-11-25T01:14:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9496510.1371/journal.pone.0094965Exopolysaccharides isolated from hydrothermal vent bacteria can modulate the complement system.Anthony CourtoisChristian BerthouJean GuézennecClaire BoissetAnne BordronThe complement system is involved in the defence against bacterial infection, or in the elimination of tumour cells. However, disturbances in this system contributes to the pathogenesis of various inflammatory diseases. The efficiency of therapeutic anti-tumour antibodies is enhanced when the complement system is stimulated. In contrast, cancer cells are able to inhibit the complement system and thus proliferate. Some marine molecules are currently being developed as new drugs for use in humans. Among them, known exopolyssacharides (EPSs) generally originate from fungi, but few studies have been performed on bacterial EPSs and even fewer on EPSs extracted from deep-sea hydrothermal vent microbes. For use in humans, these high molecular weight EPSs must be depolymerised. Furthermore, the over-sulphation of EPSs can modify their biological activity. The aim of this study was to investigate the immunodulation of the complement system by either native or over-sulphated low molecular weight EPSs isolated from vent bacteria in order to find pro or anti-activators of complement.http://europepmc.org/articles/PMC3988086?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anthony Courtois Christian Berthou Jean Guézennec Claire Boisset Anne Bordron |
spellingShingle |
Anthony Courtois Christian Berthou Jean Guézennec Claire Boisset Anne Bordron Exopolysaccharides isolated from hydrothermal vent bacteria can modulate the complement system. PLoS ONE |
author_facet |
Anthony Courtois Christian Berthou Jean Guézennec Claire Boisset Anne Bordron |
author_sort |
Anthony Courtois |
title |
Exopolysaccharides isolated from hydrothermal vent bacteria can modulate the complement system. |
title_short |
Exopolysaccharides isolated from hydrothermal vent bacteria can modulate the complement system. |
title_full |
Exopolysaccharides isolated from hydrothermal vent bacteria can modulate the complement system. |
title_fullStr |
Exopolysaccharides isolated from hydrothermal vent bacteria can modulate the complement system. |
title_full_unstemmed |
Exopolysaccharides isolated from hydrothermal vent bacteria can modulate the complement system. |
title_sort |
exopolysaccharides isolated from hydrothermal vent bacteria can modulate the complement system. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
The complement system is involved in the defence against bacterial infection, or in the elimination of tumour cells. However, disturbances in this system contributes to the pathogenesis of various inflammatory diseases. The efficiency of therapeutic anti-tumour antibodies is enhanced when the complement system is stimulated. In contrast, cancer cells are able to inhibit the complement system and thus proliferate. Some marine molecules are currently being developed as new drugs for use in humans. Among them, known exopolyssacharides (EPSs) generally originate from fungi, but few studies have been performed on bacterial EPSs and even fewer on EPSs extracted from deep-sea hydrothermal vent microbes. For use in humans, these high molecular weight EPSs must be depolymerised. Furthermore, the over-sulphation of EPSs can modify their biological activity. The aim of this study was to investigate the immunodulation of the complement system by either native or over-sulphated low molecular weight EPSs isolated from vent bacteria in order to find pro or anti-activators of complement. |
url |
http://europepmc.org/articles/PMC3988086?pdf=render |
work_keys_str_mv |
AT anthonycourtois exopolysaccharidesisolatedfromhydrothermalventbacteriacanmodulatethecomplementsystem AT christianberthou exopolysaccharidesisolatedfromhydrothermalventbacteriacanmodulatethecomplementsystem AT jeanguezennec exopolysaccharidesisolatedfromhydrothermalventbacteriacanmodulatethecomplementsystem AT claireboisset exopolysaccharidesisolatedfromhydrothermalventbacteriacanmodulatethecomplementsystem AT annebordron exopolysaccharidesisolatedfromhydrothermalventbacteriacanmodulatethecomplementsystem |
_version_ |
1725158921574809600 |