Aqueous Extract of Semen Ziziphi Spinosae Exerts Anxiolytic Effects during Nicotine Withdrawal via Improvement of Amygdaloid CRF/CRF1R Signaling

Aqueous Extract of Semen Ziziphi Spinosae Exerts Anxiolytic Effects during Nicotine Withdrawal via Improvement of Amygdaloid CRF/CRF1R Signaling

Anxiety during nicotine withdrawal (NicW) is a key risk factor for smoking relapse. Semen Ziziphi Spinosae (SZS), which is a prototypical hypnotic-sedative herb in Oriental medicine, has been clinically used to treat insomnia and general anxiety disorders for thousands of years. Thus, the present st...

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Bibliographic Details
Main Authors:	Changhong Gu, ZhengLin Zhao, Xiaodong Zhu, Tong Wu, Bong Hyo Lee, Yu Jiao, Chul Won Lee, Dae Hwa Jung, Chae Ha Yang, Rongjie Zhao, Sang Chan Kim
Format:	Article
Language:	English
Published:	Hindawi Limited 2018-01-01
Series:	Evidence-Based Complementary and Alternative Medicine
Online Access:	http://dx.doi.org/10.1155/2018/2419183

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