Contributions from Mexican Flora for the Treatment of Diabetes Mellitus: Molecules of <i>Psacalium decompositum</i> (A. Gray) H. Rob & Brettell
Diabetes mellitus (DM) is cited as a serious worldwide health problem that occupies second place in causes of annual mortality in Mexico. Among Mexican flora, nearly 300 plant species have been employed as hypoglycemic in popular use. Thus, their study entertains great relevance In this context, thi...
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doaj-bbf532bc87194fd9a4a9544823c409d42021-05-31T23:57:31ZengMDPI AGMolecules1420-30492021-05-01262892289210.3390/molecules26102892Contributions from Mexican Flora for the Treatment of Diabetes Mellitus: Molecules of <i>Psacalium decompositum</i> (A. Gray) H. Rob & BrettellManuel Jiménez-Estrada0Maira Huerta-Reyes1Rosario Tavera-Hernández2J. Javier Alvarado-Sansininea3Ana Berenice Alvarez4Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, Coyoacán 04510, MexicoUnidad de Investigación Médica en Enfermedades Nefrológicas, Hospital de Especialidades “Dr. Bernardo Sepúlveda Gutiérrez”, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cuauhtémoc 06720, MexicoInstituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, Coyoacán 04510, MexicoInstituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, Coyoacán 04510, MexicoInstituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, Coyoacán 04510, MexicoDiabetes mellitus (DM) is cited as a serious worldwide health problem that occupies second place in causes of annual mortality in Mexico. Among Mexican flora, nearly 300 plant species have been employed as hypoglycemic in popular use. Thus, their study entertains great relevance In this context, this work contributes a clear and timely review of the plant species utilized in Traditional Mexican Medicine and experimental biological models in which not only have the hypoglycemic properties of the extracts and the isolated compounds been considered, but also the anti-inflammatory and antioxidant properties, taking into account an integral focus based on the complex mechanisms involved in the pathogenesis and physiopathology of DM. Among the species reviewed, we highlight <i>Psacalium decompositum</i> (Asteraceae), due to the potent hypoglycemic, anti-inflammatory, and antioxidant activity of the sesquiterpenes identified as majority compounds isolated from the root, such as cacalol and cacalone that also possess the capacity of increasing insulin levels. In this manner, the present manuscript attempts to contribute necessary information for the future study of bioactive molecules that are useful in the treatment of DM, as well as also being a contribution to the knowledge and diffusion of Mexican Traditional Medicine.https://www.mdpi.com/1420-3049/26/10/2892Mexican medicinal plantshypoglycemic<i>Psacalium decompositum</i>sesquiterpenescacalolcacalone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Manuel Jiménez-Estrada Maira Huerta-Reyes Rosario Tavera-Hernández J. Javier Alvarado-Sansininea Ana Berenice Alvarez |
spellingShingle |
Manuel Jiménez-Estrada Maira Huerta-Reyes Rosario Tavera-Hernández J. Javier Alvarado-Sansininea Ana Berenice Alvarez Contributions from Mexican Flora for the Treatment of Diabetes Mellitus: Molecules of <i>Psacalium decompositum</i> (A. Gray) H. Rob & Brettell Molecules Mexican medicinal plants hypoglycemic <i>Psacalium decompositum</i> sesquiterpenes cacalol cacalone |
author_facet |
Manuel Jiménez-Estrada Maira Huerta-Reyes Rosario Tavera-Hernández J. Javier Alvarado-Sansininea Ana Berenice Alvarez |
author_sort |
Manuel Jiménez-Estrada |
title |
Contributions from Mexican Flora for the Treatment of Diabetes Mellitus: Molecules of <i>Psacalium decompositum</i> (A. Gray) H. Rob & Brettell |
title_short |
Contributions from Mexican Flora for the Treatment of Diabetes Mellitus: Molecules of <i>Psacalium decompositum</i> (A. Gray) H. Rob & Brettell |
title_full |
Contributions from Mexican Flora for the Treatment of Diabetes Mellitus: Molecules of <i>Psacalium decompositum</i> (A. Gray) H. Rob & Brettell |
title_fullStr |
Contributions from Mexican Flora for the Treatment of Diabetes Mellitus: Molecules of <i>Psacalium decompositum</i> (A. Gray) H. Rob & Brettell |
title_full_unstemmed |
Contributions from Mexican Flora for the Treatment of Diabetes Mellitus: Molecules of <i>Psacalium decompositum</i> (A. Gray) H. Rob & Brettell |
title_sort |
contributions from mexican flora for the treatment of diabetes mellitus: molecules of <i>psacalium decompositum</i> (a. gray) h. rob & brettell |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2021-05-01 |
description |
Diabetes mellitus (DM) is cited as a serious worldwide health problem that occupies second place in causes of annual mortality in Mexico. Among Mexican flora, nearly 300 plant species have been employed as hypoglycemic in popular use. Thus, their study entertains great relevance In this context, this work contributes a clear and timely review of the plant species utilized in Traditional Mexican Medicine and experimental biological models in which not only have the hypoglycemic properties of the extracts and the isolated compounds been considered, but also the anti-inflammatory and antioxidant properties, taking into account an integral focus based on the complex mechanisms involved in the pathogenesis and physiopathology of DM. Among the species reviewed, we highlight <i>Psacalium decompositum</i> (Asteraceae), due to the potent hypoglycemic, anti-inflammatory, and antioxidant activity of the sesquiterpenes identified as majority compounds isolated from the root, such as cacalol and cacalone that also possess the capacity of increasing insulin levels. In this manner, the present manuscript attempts to contribute necessary information for the future study of bioactive molecules that are useful in the treatment of DM, as well as also being a contribution to the knowledge and diffusion of Mexican Traditional Medicine. |
topic |
Mexican medicinal plants hypoglycemic <i>Psacalium decompositum</i> sesquiterpenes cacalol cacalone |
url |
https://www.mdpi.com/1420-3049/26/10/2892 |
work_keys_str_mv |
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