Assessment of Elevated Serum Tumor Markers Carcinoembryonic Antigen (CEA) and Cancer Antigen 15-3 (CA15-3) among Patients with Different Subtypes of Metastatic Breast Cancer
Background: Cancer antigen 15-3 and carcinoembryonic antigen are used in clinical and laboratory diagnosis of metastatic breast cancer. Previous studies have noted conflicting results about the association between carcinoembryonic antigen and cancer antigen 15-3 in metastatic breast cancer. The p...
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doaj-bbf73ff868274aa8ad21cad13d3cfbef2020-11-25T02:54:39ZengShiraz University of Medical SciencesMiddle East Journal of Cancer 2008-67092008-66872019-01-011011722Assessment of Elevated Serum Tumor Markers Carcinoembryonic Antigen (CEA) and Cancer Antigen 15-3 (CA15-3) among Patients with Different Subtypes of Metastatic Breast CancerAli Taghizadeh0Leila Pourali1Mona Joudi2Maryam Salehi3Shohreh Eshghi4Farnaz Torabian5Azin Esmaeelpour6Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranSurgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Socio-Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranCancer Research Center, Mashhad University of Medical Sciences, Mashhad, IranMedical Student, Faculty of Medicine, Islamic Azad University, Mashhad Branch, Mashhad, IranStudent Research Committee, Birjand University of Medical Sciences, Birjand, IranBackground: Cancer antigen 15-3 and carcinoembryonic antigen are used in clinical and laboratory diagnosis of metastatic breast cancer. Previous studies have noted conflicting results about the association between carcinoembryonic antigen and cancer antigen 15-3 in metastatic breast cancer. The present study examined serum tumor marker levels of carcinoembryonic antigen and cancer antigen 15-3 among patients with different subtypes of metastatic breast cancer. Methods: In this cross-sectional study, we assessed metastatic breast cancer patients diagnosed between 2005 and 2012 who referred to academic Hospitals affiliated with Mashhad University of Medical Sciences. The patients were selected by systematic randomization sampling. Demographic, clinical, pathological, and therapeutic data were collected from patients’ hospital records. Statistical analyses were performed by Statistical Package for the Social Sciences version 16.0 software. Results: A total of 298 eligible patients enrolled in the study. Patients’ median age was 48.39±12.57 years. Elevated serum levels of carcinoembryonic antigen were identified in 65.17% of patients and cancer antigen 15-3 in 57.29% of patients. Based on molecular subtype categorization, 109 (39.5%) patients were human epidermal growth factor receptor 2 negative and 105 (38.0%) patients were in the luminal group. There was no significant correlation between serum carcinoembryonic antigen and cancer antigen 15-3 with subtypes of the tumor. The most common sites for metastasis were bones and liver, respectively. However, there was no significant correlation between serum carcinoembryonic antigen and cancer antigen 15-3 with the site of metastasis. There was a significant association between serum carcinoembryonic antigen level and stages IIA and IV. Conclusion: One of the most significant findings of the current study was the increased serum carcinoembryonic antigen and cancer antigen 15-3 levels in most metastatic breast cancer participants. We postulate that regular measurement of serum cancer antigen 15-3 and carcinoembryonic antigen could be useful for earlier detection and prediction of outcomes.http://mejc.sums.ac.ir/index.php/mejc/article/view/800Breast cancerMetastasisCancer antigen 15-3 (CA15-3)Carcinoembryonic antigen (CEA) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ali Taghizadeh Leila Pourali Mona Joudi Maryam Salehi Shohreh Eshghi Farnaz Torabian Azin Esmaeelpour |
spellingShingle |
Ali Taghizadeh Leila Pourali Mona Joudi Maryam Salehi Shohreh Eshghi Farnaz Torabian Azin Esmaeelpour Assessment of Elevated Serum Tumor Markers Carcinoembryonic Antigen (CEA) and Cancer Antigen 15-3 (CA15-3) among Patients with Different Subtypes of Metastatic Breast Cancer Middle East Journal of Cancer Breast cancer Metastasis Cancer antigen 15-3 (CA15-3) Carcinoembryonic antigen (CEA) |
author_facet |
Ali Taghizadeh Leila Pourali Mona Joudi Maryam Salehi Shohreh Eshghi Farnaz Torabian Azin Esmaeelpour |
author_sort |
Ali Taghizadeh |
title |
Assessment of Elevated Serum Tumor Markers Carcinoembryonic Antigen (CEA) and Cancer Antigen 15-3 (CA15-3) among Patients with Different Subtypes of Metastatic Breast Cancer |
title_short |
Assessment of Elevated Serum Tumor Markers Carcinoembryonic Antigen (CEA) and Cancer Antigen 15-3 (CA15-3) among Patients with Different Subtypes of Metastatic Breast Cancer |
title_full |
Assessment of Elevated Serum Tumor Markers Carcinoembryonic Antigen (CEA) and Cancer Antigen 15-3 (CA15-3) among Patients with Different Subtypes of Metastatic Breast Cancer |
title_fullStr |
Assessment of Elevated Serum Tumor Markers Carcinoembryonic Antigen (CEA) and Cancer Antigen 15-3 (CA15-3) among Patients with Different Subtypes of Metastatic Breast Cancer |
title_full_unstemmed |
Assessment of Elevated Serum Tumor Markers Carcinoembryonic Antigen (CEA) and Cancer Antigen 15-3 (CA15-3) among Patients with Different Subtypes of Metastatic Breast Cancer |
title_sort |
assessment of elevated serum tumor markers carcinoembryonic antigen (cea) and cancer antigen 15-3 (ca15-3) among patients with different subtypes of metastatic breast cancer |
publisher |
Shiraz University of Medical Sciences |
series |
Middle East Journal of Cancer |
issn |
2008-6709 2008-6687 |
publishDate |
2019-01-01 |
description |
Background: Cancer antigen 15-3 and carcinoembryonic antigen are used in clinical and
laboratory diagnosis of metastatic breast cancer. Previous studies have noted conflicting results
about the association between carcinoembryonic antigen and cancer antigen 15-3 in metastatic
breast cancer. The present study examined serum tumor marker levels of carcinoembryonic antigen
and cancer antigen 15-3 among patients with different subtypes of metastatic breast cancer.
Methods: In this cross-sectional study, we assessed metastatic breast cancer patients
diagnosed between 2005 and 2012 who referred to academic Hospitals affiliated with Mashhad
University of Medical Sciences. The patients were selected by systematic randomization
sampling. Demographic, clinical, pathological, and therapeutic data were collected from
patients’ hospital records. Statistical analyses were performed by Statistical Package for the Social
Sciences version 16.0 software.
Results: A total of 298 eligible patients enrolled in the study. Patients’ median age was
48.39±12.57 years. Elevated serum levels of carcinoembryonic antigen were identified in
65.17% of patients and cancer antigen 15-3 in 57.29% of patients. Based on molecular subtype
categorization, 109 (39.5%) patients were human epidermal growth factor receptor 2 negative
and 105 (38.0%) patients were in the luminal group. There was no significant correlation between
serum carcinoembryonic antigen and cancer antigen 15-3 with subtypes of the tumor. The most
common sites for metastasis were bones and liver, respectively. However, there was no
significant correlation between serum carcinoembryonic antigen and cancer antigen 15-3 with
the site of metastasis. There was a significant association between serum carcinoembryonic antigen
level and stages IIA and IV.
Conclusion: One of the most significant findings of the current study was the increased serum
carcinoembryonic antigen and cancer antigen 15-3 levels in most metastatic breast cancer
participants. We postulate that regular measurement of serum cancer antigen 15-3 and carcinoembryonic
antigen could be useful for earlier detection and prediction of outcomes. |
topic |
Breast cancer Metastasis Cancer antigen 15-3 (CA15-3) Carcinoembryonic antigen (CEA) |
url |
http://mejc.sums.ac.ir/index.php/mejc/article/view/800 |
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