Dietary restriction of amino acids for Cancer therapy

• Main Author: Jian-Sheng Kang
• Format: Article
• Language: English
• Published: BMC 2020-03-01
• Series: Nutrition & Metabolism
• Subjects: Amino acid restriction; Cancer; Lysine; Kwashiorkor; Tryptophan; Arginine
• Online Access: http://link.springer.com/article/10.1186/s12986-020-00439-x

Abstract Biosyntheses of proteins, nucleotides and fatty acids, are essential for the malignant proliferation and survival of cancer cells. Cumulating research findings show that amino acid restrictions are potential strategies for cancer interventions. Meanwhile, dietary strategies are popular among cancer patients. However, there is still lacking solid rationale to clarify what is the best strategy, why and how it is. Here, integrated analyses and comprehensive summaries for the abundances, signalling and functions of amino acids in proteomes, metabolism, immunity and food compositions, suggest that, intermittent dietary lysine restriction with normal maize as an intermittent staple food for days or weeks, might have the value and potential for cancer prevention or therapy. Moreover, dietary supplements were also discussed for cancer cachexia including dietary immunomodulatory.